Yale Autoimmune and Cholestatic Liver Disease Program


The Yale Autoimmune and Cholestatic Liver Disease Program (YACLDP) consists of dedicated experts and support staff committed to cutting-edge care and innovative research to patients with disorders including Autoimmune Hepatitis (AIH), Primary Biliary Cholangitis (PBC), and Primary Sclerosing Cholangitis (PSC).

In the YACLDP, the care and management of patients with these disorders is integrated with the breadth of Yale’s expertise in patient care, education, and clinical and laboratory research. Since its origins Yale Digestive Diseases has sustained a 50-year tradition of excellence in liver research and patient care, and continues to bear a national and international influence on the study and treatment of liver disorders. As a partner of the Yale Liver Center (YLC) — one of only four NIH-sponsored liver research centers in the United States— it is the only center in Connecticut that offers comprehensive patient care for individuals with autoimmune and cholestatic liver disease.


Patient Care

The key to effective management of chronic liver diseases is coordinated care among specially trained physicians. Dr. James Boyer, Dr. David Assis and Dr. Marina Silveira lead clinics specifically centered on these rare diseases. The YACLDP has close relationships with specialists in adult and pediatric gastroenterology, advanced endoscopy, transplant hepatology, transplant surgery, gastrointestinal pathology, diagnostic and interventional radiology, gastrointestinal surgery, rheumatology, endocrinology, and medical and surgical oncology.


Research

Dr. Boyer, Dr. Assis and Dr. Silveira are also active members of the Yale Liver Center, a world-class NIH-funded research center, and actively conduct a number of novel clinical and basic science research studies in this field. Further, the Yale program is a key organizer of the North American Consortium for Autoimmune Liver Disease.

Examples of recent clinical projects include a pilot study of a new drug for the treatment of PSC and a study evaluating the relationship between psychological stress and inflammation in AIH.

 

For more information about the Yale Autoimmune and Cholestatic Liver Disease Program, please call 203-785-4138 or email Diane Giordano

Program Team

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David Assis, MD

Assistant Professor of Medicine (Digestive Diseases)

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James Lorenzen Boyer, MD, FACEP

Ensign Professor of Medicine (Digestive Diseases)

Emeritus Director, Yale Liver Center

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