Digestive Diseases Publications

Clara Abraham, MD

Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA: Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29; 2017 Jun 21. PMID: 28636595

Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. Nat Commun. 2017 Jun 28; 2017 Jun 28. PMID: 28656966

Lahiri A, Hedl M, Yan J, Abraham C: Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes. Nat Commun. 2017 Jun 8; 2017 Jun 8. PMID: 28593945

Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR: ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 Feb 23; 2017 Feb 23. PMID: 28230865

Abraham C, Dulai PS, Vermeire S, Sandborn WJ: Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. Gastroenterology. 2017 Feb; 2016 Oct 22. PMID: 27780712

Hedl M, Abraham C: A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion. Gut. 2016 Nov; 2015 Jul 27. PMID: 26215868

Hedl M, Proctor DD, Abraham C: JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages. J Immunol. 2016 Nov 1; 2016 Sep 23. PMID: 27664279

Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R, Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K, Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH: A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF. Gastroenterology. 2016 Oct; 2016 Jul 1. PMID: 27377463

Hedl M, Yan J, Abraham C: IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. Cell Rep. 2016 Aug 30; 2016 Aug 18. PMID: 27545875

Zheng S, Abraham C: NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms. Mol Cell Biol. 2013 Dec; 2013 Oct 7. PMID: 24100018

Zhang CK, Hewett J, Hemming J, Grant T, Zhao H, Abraham C, Oikonomou I, Kanakia M, Cho JH, Proctor DD: The influence of depression on quality of life in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013 Jul. PMID: 23669400

Hedl M, Abraham C: NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 2013 Jan 3. PMID: 23287275

Shen H, Zhang W, Abraham C, Cho JH: Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells. PLoS One. 2013; 2013 Mar 1. PMID: 23469228

Hedl M, Abraham C: Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines. Gastroenterology. 2012 Dec; 2012 Sep 8. PMID: 22967725

Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA: IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 8; 2012 Oct 17. PMID: 23075849

Sarin R, Abraham C: CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells. Am J Physiol Gastrointest Liver Physiol. 2012 Oct; 2012 Jul 19. PMID: 22821945

Hedl M, Abraham C: IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells. J Immunol. 2012 Jun 1; 2012 Apr 27. PMID: 22544929

Zhang W, Ferguson J, Ng SM, Hui K, Goh G, Lin A, Esplugues E, Flavell RA, Abraham C, Zhao H, Cho JH: Effector CD4+ T cell expression signatures and immune-mediated disease associated genes. PLoS One. 2012; 2012 Jun 8. PMID: 22715389

Menard L, Saadoun D, Isnardi I, Ng YS, Meyers G, Massad C, Price C, Abraham C, Motaghedi R, Buckner JH, Gregersen PK, Meffre E: The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J Clin Invest. 2011 Sep; 2011 Aug 1. PMID: 21804190

Hedl M, Abraham C: Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages. J Biol Chem. 2011 Jul 29; 2011 Jun 9. PMID: 21659536

Sarin R, Wu X, Abraham C: Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses. Proc Natl Acad Sci U S A. 2011 Jun 7; 2011 May 23. PMID: 21606346

Abraham C, Medzhitov R: Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology. 2011 May. PMID: 21530739

Hedl M, Abraham C: Secretory mediators regulate Nod2-induced tolerance in human macrophages. Gastroenterology. 2011 Jan; 2010 Sep 18. PMID: 20854823

Capurso NA, Look M, Jeanbart L, Nowyhed H, Abraham C, Craft J, Fahmy TM: Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells. Self Nonself. 2010 Oct. PMID: 21487509

Zenewicz LA, Abraham C, Flavell RA, Cho JH: Unraveling the genetics of autoimmunity. Cell. 2010 Mar 19. PMID: 20303870

Abraham C, Cho JH: Inflammatory bowel disease. N Engl J Med. 2009 Nov 19. PMID: 19923578

Abraham C, Cho J: Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflamm Bowel Dis. 2009 Jul. PMID: 19253307

Abraham C, Cho JH: IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu Rev Med. 2009. PMID: 18976050

Abraham C, Hart J, Locke SM, Baker AL: A case of indometacin-induced acute hepatitis developing into chronic autoimmune hepatitis. Nat Clin Pract Gastroenterol Hepatol. 2008 Mar; 2008 Jan 29. PMID: 18227818

Cho JH, Abraham C: Inflammatory bowel disease genetics: Nod2. Annu Rev Med. 2007. PMID: 16987083

Harry Aslanian, MD

Muniraj T, Aslanian HR: New Developments in Endoscopic Ultrasound Tissue Acquisition. Gastrointest Endosc Clin N Am. 2017 Oct. PMID: 28918800

Langberg KM, Solad Y, Ciarleglio M, Sukumar N, Teslya P, Chowdhury MM, Aslanian HR: Primary Care Physicians Could Play a Role in Improving Colonoscopy Quality Measures. Dig Dis Sci. 2017 May; 2017 Mar 27. PMID: 28349232

Oza VM, Cai G, Aslanian HR: Clinical utility of rapid on-site cytopathology. Gastrointest Endosc. 2017 Jan; 2016 Aug 22. PMID: 27562939

Muniraj T, Jamidar PA, Nealon WH, Aslanian HR: Endoscopic Management of Pancreatic Fluid Collections. J Clin Gastroenterol. 2017 Jan. PMID: 27548730

McCarty TR, Bakhit M, Aslanian HR, Rustagi T: Endoscopic Management of Esophagopleural Fistula. J Clin Gastroenterol. 2016 Nov/Dec. PMID: 27552330

Tang SJ, Vilmann AS, Saftoiu A, Wang W, Streba CT, Fink PP, Griswold M, Wu R, Dietrich CF, Jenssen C, Hocke M, Kantowski M, Pohl J, Fockens P, Annema JT, van der Heijden EH, Havre RF, Pham KD, Kunda R, Deprez PH, Mariana J, Vazquez-Sequeiros E, Larghi A, Buscarini E, Fusaroli P, Lahav M, Puri R, Garg PK, Sharma M, Maluf-Filho F, Sahai A, Brugge WR, Lee LS, Aslanian HR, Wang AY, Shami VM, Markowitz A, Siddiqui AA, Mishra G, Scheiman JM, Isenberg G, Siddiqui UD, Shah RJ, Buxbaum J, Watson RR, Willingham FF, Bhutani MS, Levy MJ, Harris C, Wallace MB, Nolsøe CP, Lorentzen T, Bang N, Sørensen SM, Gilja OH, D'Onofrio M, Piscaglia F, Gritzmann N, Radzina M, Sparchez ZA, Sidhu PS, Freeman S, McCowan TC, de Araujo CR Jr, Patel A, Ali MA, Campbell G, Chen E, Vilmann P: EUS Needle Identification Comparison and Evaluation study (with videos). Gastrointest Endosc. 2016 Sep; 2016 Feb 10. PMID: 26873530

Parikh ND, Gibson J, Nagar A, Ahmed AA, Aslanian HR: Confocal laser endomicroscopy features of sessile serrated adenomas/polyps. United European Gastroenterol J. 2016 Aug; 2015 Dec 15. PMID: 27536371

Muniraj T, Aslanian HR: Awash in a Multitude of Pancreas Cysts: Can We Stop Looking? Clin Gastroenterol Hepatol. 2016 Jun; 2016 Feb 4. PMID: 26851707

Langberg KM, Parikh ND, Deng Y, Ciarlegio M, Laine L, Aslanian HR: Digital chromoendoscopy utilization in clinical practice: A survey of gastroenterologists in Connecticut. World J Gastrointest Pharmacol Ther. 2016 May 6. PMID: 27158543

Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR: Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP? Dig Dis Sci. 2016 Mar; 2015 Nov 14. PMID: 26572779

Alomari AK, Ustun B, Aslanian HR, Ge X, Chhieng D, Cai G: Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience. Cytojournal. 2016; 2016 Jan 28. PMID: 26955395

Rustagi T, McCarty TR, Aslanian HR: Endoscopic Treatment of Gastrointestinal Perforations, Leaks, and Fistulae. J Clin Gastroenterol. 2015 Nov-Dec. PMID: 26325190

Rustagi T, Aslanian HR, Laine L: Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review. J Clin Gastroenterol. 2015 Nov-Dec. PMID: 25626632

Aslanian HR, Ahmed AM, Jamidar PA: Is Advanced Endoscopy Training Worth it? Clin Gastroenterol Hepatol. 2015 Jul. PMID: 26091939

Wani S, Hall M, Keswani RN, Aslanian HR, Casey B, Burbridge R, Chak A, Chen AM, Cote G, Edmundowicz SA, Faulx AL, Hollander TG, Lee LS, Mullady D, Murad F, Muthusamy VR, Pfau PR, Scheiman JM, Tokar J, Wagh MS, Watson R, Early D: Variation in Aptitude of Trainees in Endoscopic Ultrasonography, Based on Cumulative Sum Analysis. Clin Gastroenterol Hepatol. 2015 Jul; 2014 Nov 14. PMID: 25460557

Muniraj T, Aslanian HR, Laine L, Farrell J, Ciarleglio MM, Deng Y, Ho H, Jamidar PA: A double-blind, randomized, sham-controlled trial of the effect of a radiation-attenuating drape on radiation exposure to endoscopy staff during ERCP. Am J Gastroenterol. 2015 May; 2015 Mar 31. PMID: 25823765

Rustagi T, Aslanian HR: Endoscopic strangulation techniques for treatment of upper GI mucosal and submucosal lesions. Gastrointest Endosc. 2015 Apr; 2014 Jul 12. PMID: 25028275

Solad Y, Wang C, Laine L, Deng Y, Schwartz H, Ciarleglio MM, Aslanian HR: Influence of colonoscopy quality measures on patients' colonoscopist selection. Am J Gastroenterol. 2015 Feb; 2014 Jul 29. PMID: 25070055

Muniraj T, Sahakian A, Ciarleglio MM, Deng Y, Aslanian HR: Cold snare polypectomy for large sessile colonic polyps: a single-center experience. Gastroenterol Res Pract. 2015; 2015 Mar 23. PMID: 25878658

Rustagi T, Aslanian HR: Endoscopic management of biliary leaks after laparoscopic cholecystectomy. J Clin Gastroenterol. 2014 Sep. PMID: 24296422

Bernstein J, Adeniran AJ, Cai G, Theoharis CG, Ustun B, Beckman D, Aslanian HR, Harigopal M: Endoscopic ultrasound-guided fine-needle aspiration diagnosis of Merkel cell carcinoma metastatic to the pancreas. Diagn Cytopathol. 2014 Mar; 2012 Jun 25. PMID: 22730170

Sahakian AB, Aslanian HR, Mehra M, Rossi F, Laine L, Sanchez M, Ciarleglio MM, Adimoolam V, Siddiqui UD: The utility of esophagogastroduodenoscopy before endoscopic ultrasonography in patients undergoing endoscopic ultrasonography for pancreatico-biliary and mediastinal indications. J Clin Gastroenterol. 2013 Nov-Dec. PMID: 23632349

Bari K, Aslanian HR, Pollak J, Reiner E, Salem RR, Taddei TH, Emre SH, Jamidar PA: Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography. ACG Case Rep J. 2013 Oct; 2013 Oct 8. PMID: 26157820

Ho HC, Eloubeidi MA, Siddiqui UD, Brugge WR, Rossi F, Bounds BW, Aslanian HR: Endosonographic and cyst fluid characteristics of cystic pancreatic neuroendocrine tumours: a multicentre case series. Dig Liver Dis. 2013 Sep; 2013 Apr 9. PMID: 23582348

Bernstein J, Ustun B, Alomari A, Bao F, Aslanian HR, Siddiqui U, Chhieng D, Cai G: Performance of endoscopic ultrasound-guided fine needle aspiration in diagnosing pancreatic neuroendocrine tumors. Cytojournal. 2013; 2013 May 29. PMID: 23858320

Aslanian HR, Shieh FK, Chan FW, Ciarleglio MM, Deng Y, Rogart JN, Jamidar PA, Siddiqui UD: Nurse observation during colonoscopy increases polyp detection: a randomized prospective study. Am J Gastroenterol. 2013 Feb. PMID: 23381064

Muniraj T, Vignesh S, Shetty S, Thiruvengadam S, Aslanian HR: Pancreatic neuroendocrine tumors. Dis Mon. 2013 Jan. PMID: 23312533

Muniraj T, Aslanian HR: Hypertriglyceridemia independent propofol-induced pancreatitis. JOP. 2012 Jul 10; 2012 Jul 10. PMID: 22797405

Adimoolam V, Sanchez MJ, Siddiqui UD, Yu S, Dzuira JD, Padda MS, Aslanian HR: Endoscopic ultrasound identifies synchronous pancreas cystic lesions not seen on initial cross-sectional imaging. Pancreas. 2011 Oct. PMID: 21705942

Aslanian HR, Estrada JD, Rossi F, Dziura J, Jamidar PA, Siddiqui UD: Endoscopic ultrasound and endoscopic retrograde cholangiopancreatography for obstructing pancreas head masses: combined or separate procedures? J Clin Gastroenterol. 2011 Sep. PMID: 21301359

Siddiqui UD, Rossi F, Padda MS, Rosenthal LS, Aslanian HR: Patient preferences after endoscopic ultrasound with fine needle aspiration (EUS-FNA) diagnosis of pancreas cancer: rapid communication valued over long-term relationships. Pancreas. 2011 Jul. PMID: 21602735

Nagarajan P, Cai G, Padda MS, Selbst M, Kowalski D, Proctor DD, Chhieng D, Aslanian HR, Harigopal M: Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy. Diagn Cytopathol. 2011 May. PMID: 21488173

Nagler AK, Aslanian HR, Siddiqui UD: Endoscopic ultrasound and gastric lesions. J Clin Gastroenterol. 2011 Mar. PMID: 21278579

Rogart JN, Aslanian HR, Siddiqui UD: Narrow band imaging to detect residual or recurrent neoplastic tissue during surveillance endoscopy. Dig Dis Sci. 2011 Feb; 2010 Jun 9. PMID: 20532981

Chander B, Aslanian HR: Gastric perforations associated with the use of crack cocaine. Gastroenterol Hepatol (N Y). 2010 Nov. PMID: 21437024

Siddiqui UD, Rossi F, Rosenthal LS, Padda MS, Murali-Dharan V, Aslanian HR: EUS-guided FNA of solid pancreatic masses: a prospective, randomized trial comparing 22-gauge and 25-gauge needles. Gastrointest Endosc. 2009 Dec; 2009 Jul 28. PMID: 19640524

Padda MS, Aslanian HR, Theoharis C: Young female with pancreatic mass. Gastroenterology. 2009 Sep; 2009 Jul 29. PMID: 19646403

Rogart JN, Aslanian HR: Massive hemobilia after transjugular liver biopsy treated endoscopically and angiographically. Clin Gastroenterol Hepatol. 2008 Dec. PMID: 19081523

Aslanian HR, Burgart LJ, Harrington JJ, Mahoney DW, Zinsmeister AR, Thibodeau SN, Ahlquist DA: Altered DNA mismatch repair expression in synchronous and metachronous colorectal cancers. Clin Gastroenterol Hepatol. 2008 Dec; 2008 Jul 17. PMID: 18639494

Rogart JN, Siddiqui UD, Jamidar PA, Aslanian HR: Fellow involvement may increase adenoma detection rates during colonoscopy. Am J Gastroenterol. 2008 Nov; 2008 Aug 27. PMID: 18759826

Rossi F, Sosa JA, Aslanian HR: Screening colonoscopy and fecal occult blood testing practice patterns: a population-based survey of gastroenterologists. J Clin Gastroenterol. 2008 Nov-Dec. PMID: 18936643

David Assis, MD

Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL: Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study. J Clin Gastroenterol. 2017 Feb. PMID: 27428727

Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R: A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients. Dig Dis Sci. 2016 Dec; 2016 Oct 1. PMID: 27696094

Assis DN, Freedman SD: Gastrointestinal Disorders in Cystic Fibrosis. Clin Chest Med. 2016 Mar; 2015 Dec 24. PMID: 26857772

Ghonem NS, Assis DN, Boyer JL: Fibrates and cholestasis. Hepatology. 2015 Aug; 2015 Mar 23. PMID: 25678132

Assis DN, Levy C: Editorial: environmental risk factors for PSC with and without IBD--the story unfolds. Aliment Pharmacol Ther. 2015 Jun. PMID: 25939466

Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R: The role of macrophage migration inhibitory factor in autoimmune liver disease. Hepatology. 2014 Feb; 2013 Dec 20. PMID: 23913513

Assis DN, Lim JK: New pharmacotherapy for hepatitis C. Clin Pharmacol Ther. 2012 Sep; 2012 Aug 1. PMID: 22850602

Assis DN, Pollak J, Schilsky ML, Emre S: Successful treatment of a bleeding umbilical varix by percutaneous umbilical vein embolization with sclerotherapy. J Clin Gastroenterol. 2012 Feb. PMID: 21897280

Assis DN, Schilsky ML: Testing and management of thrombocytopenia and coagulopathy in the pre- and postliver transplant patient. Minerva Gastroenterol Dietol. 2010 Sep. PMID: 21037549

James Lorenzen Boyer, MD, FACEP

Li M, Cai SY, Boyer JL: Mechanisms of bile acid mediated inflammation in the liver. Mol Aspects Med. 2017 Aug; 2017 Jul 1. PMID: 28606651

Boyer JL: Maintaining a Vibrant and Productive Laboratory as a Senior Investigator. Cell Mol Gastroenterol Hepatol. 2017 Sep; 2017 Jun 7. PMID: 28840184

Yu D, Zhang H, Lionarons DA, Boyer JL, Cai SY: Na+-taurocholate cotransporting polypeptide (NTCP/SLC10A1) ortholog in the marine skate Leucoraja erinacea is not a physiological bile salt transporter. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1; 2017 Jan 11. PMID: 28077388

Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL: Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714

Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL: Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study. J Clin Gastroenterol. 2017 Feb. PMID: 27428727

Li M, Soroka CJ, Harry K, Boyer JL: CFTR-associated ligand is a negative regulator of Mrp2 expression. Am J Physiol Cell Physiol. 2017 Jan 1; 2016 Nov 9. PMID: 27834195

Cai SY, Boyer JL: The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage. Dig Dis. 2017; 2017 Mar 1. PMID: 28249287

Cai SY, Boyer JL: Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury. Inflamm Cell Signal. 2017; 2017 Jun 19. PMID: 28804737

Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R: A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients. Dig Dis Sci. 2016 Dec; 2016 Oct 1. PMID: 27696094

Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL: Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis. Hepatology. 2016 Dec; 2016 Oct 28. PMID: 27639250

Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL: A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PLoS One. 2016; 2016 Jun 28. PMID: 27351185

Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W: Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. J Hepatol. 2015 Dec; 2015 Jul 23. PMID: 26212029

Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL: Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology. 2015 Oct; 2015 Aug 22. PMID: 26108984

Ghonem NS, Assis DN, Boyer JL: Fibrates and cholestasis. Hepatology. 2015 Aug; 2015 Mar 23. PMID: 25678132

Boyer JL: The origins of hepatobiliary and gastrointestinal physiology. Hepatology. 2015 May; 2015 Mar 18. PMID: 25677183

Lee JW, Park HS, Park SA, Ryu SH, Meng W, Jürgensmeier JM, Kurie JM, Hong WK, Boyer JL, Herbst RS, Koo JS: A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. PLoS One. 2015; 2015 Apr 21. PMID: 25897662

Perry RJ, Zhang D, Zhang XM, Boyer JL, Shulman GI: Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. Science. 2015 Mar 13; 2015 Feb 26. PMID: 25721504

Boyer JL: The hepatobiliary paracellular pathway: a paradigm revisited. Gastroenterology. 2014 Nov; 2014 Sep 26. PMID: 25263297

Vasan N, Boyer JL, Herbst RS: A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer. Clin Cancer Res. 2014 Aug 1; 2014 Jun 3. PMID: 24893629

Soroka CJ, Boyer JL: Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations. Mol Aspects Med. 2014 Jun; 2013 May 15. PMID: 23685087

Cai SY, Mennone A, Soroka CJ, Boyer JL: Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 2014 Jan 30. PMID: 24481602

Cai SY, Mennone A, Soroka CJ, Boyer JL: All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice. J Pharmacol Exp Ther. 2014 Apr; 2014 Feb 3. PMID: 24492652

Mistry PK, Liu J, Sun L, Chuang WL, Yuen T, Yang R, Lu P, Zhang K, Li J, Keutzer J, Stachnik A, Mennone A, Boyer JL, Jain D, Brady RO, New MI, Zaidi M: Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease. Proc Natl Acad Sci U S A. 2014 Apr 1; 2014 Mar 17. PMID: 24639522

Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL: Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion. Hepatology. 2014 Mar; 2014 Jan 27. PMID: 24122873

Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R: The role of macrophage migration inhibitory factor in autoimmune liver disease. Hepatology. 2014 Feb; 2013 Dec 20. PMID: 23913513

Toll BA, Rojewski AM, Duncan LR, Latimer-Cheung AE, Fucito LM, Boyer JL, O'Malley SS, Salovey P, Herbst RS: "Quitting smoking will benefit your health": the evolution of clinician messaging to encourage tobacco cessation. Clin Cancer Res. 2014 Jan 15; 2014 Jan 16. PMID: 24436474

Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL: Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. J Hepatol. 2014 Jan; 2013 Aug 23. PMID: 23978715

Boyer JL: Bile formation and secretion. Compr Physiol. 2013 Jul. PMID: 23897680

Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL: Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology. 2013 Jun. PMID: 23175353

Goldberg SB, Schlessinger J, Boyer JL, Herbst RS: A step towards treating KRAS-mutant NSCLC. Lancet Oncol. 2013 Jan; 2012 Nov 28. PMID: 23200176

Lionarons DA, Boyer JL, Cai SY: Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2). J Lipid Res. 2012 Aug; 2012 Jun 5. PMID: 22669917

Lam P, Xu S, Soroka CJ, Boyer JL: A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis. Hepatology. 2012 Jun; 2012 Apr 25. PMID: 22161577

Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL: Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am J Physiol Gastrointest Liver Physiol. 2012 May 1; 2012 Feb 16. PMID: 22345550

Koo PJ, Morgensztern D, Boyer JL, Herbst RS: Targeting vascular endothelial growth factor in patients with squamous cell lung cancer. J Clin Oncol. 2012 Apr 1; 2012 Feb 21. PMID: 22355057

Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL: Ostα depletion protects liver from oral bile acid load. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 2011 Jun 30. PMID: 21719738

He H, Mennone A, Boyer JL, Cai SY: Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. Hepatology. 2011 Feb; 2010 Dec 10. PMID: 21274875

McCrann CH, Boyer JL: Small-duct sclerosing cholangitis associated with Schistosoma mansoni. Hepatology. 2011 Feb; 2010 Sep 29. PMID: 20882579

Srivastava S, Boyer JL: Psychological stress is associated with relapse in type 1 autoimmune hepatitis. Liver Int. 2010 Nov; 2010 Sep 16. PMID: 20849437

Mennone A, Soroka CJ, Harry KM, Boyer JL: Role of breast cancer resistance protein in the adaptive response to cholestasis. Drug Metab Dispos. 2010 Oct; 2010 Jul 2. PMID: 20601550

Cai SY, He H, Nguyen T, Mennone A, Boyer JL: Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms. J Lipid Res. 2010 Aug; 2010 Mar 25. PMID: 20338915

Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535

Li M, Wang W, Soroka CJ, Mennone A, Harry K, Weinman EJ, Boyer JL: NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem. 2010 Jun 18; 2010 Apr 19. PMID: 20404332

Soroka CJ, Ballatori N, Boyer JL: Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422499

Lam P, Soroka CJ, Boyer JL: The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422495

Boyer JL: Cholestasis: genetic and acquired. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422493

Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL: Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology. 2010 Jan. PMID: 19902485

Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression. Hepatology. 2009 Nov. PMID: 19821532

Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL: ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology. 2009 Mar; 2008 Nov 1. PMID: 19027009

Boyer JL: It's all about bile. Hepatology. 2009 Mar. PMID: 19242972

Wang L, Dong H, Soroka CJ, Wei N, Boyer JL, Hochstrasser M: Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Hepatology. 2008 Nov. PMID: 18798335

Soroka CJ, Xu S, Mennone A, Lam P, Boyer JL: N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta. BMC Cell Biol. 2008 Oct 10; 2008 Oct 10. PMID: 18847488

Boyer JL: Bile canalicular secretion - tales from Vienna and Yale. Wien Med Wochenschr. 2008. PMID: 18998067

Lam P, Pearson CL, Soroka CJ, Xu S, Mennone A, Boyer JL: Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases. Am J Physiol Cell Physiol. 2007 Nov; 2007 Sep 13. PMID: 17855769

Cai SY, Xiong L, Wray CG, Ballatori N, Boyer JL: The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 2007 Jun 13. PMID: 17567710

Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL: Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Feb 1. PMID: 17272513

Boyer JL: New perspectives for the treatment of cholestasis: lessons from basic science applied clinically. J Hepatol. 2007 Mar; 2006 Dec 18. PMID: 17223219

Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, Boyer JL: Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes. Gastroenterology. 2006 Sep. PMID: 16952556

Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N: Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 2006 Jan 19. PMID: 16423920

Cai SY, Boyer JL: FXR: a target for cholestatic syndromes? Expert Opin Ther Targets. 2006 Jun. PMID: 16706681

Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL: Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology. 2006 May. PMID: 16628672

Denk GU, Cai SY, Chen WS, Lin A, Soroka CJ, Boyer JL: A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology. World J Gastroenterol. 2006 Apr 28. PMID: 16688799

Wilson JH, Paturzo FX, Johnson LK, Carreiro MP, Hixson DC, Mennone A, Boyer JL, Pober JS, Harding MJ: Rat hepatocyte engraftment in severe combined immunodeficient x beige mice using mouse-specific anti-fas antibody. Xenotransplantation. 2006 Jan. PMID: 16497212

Boyer JL: Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease? Gastroenterology. 2005 Aug. PMID: 16083726

Sheela H, Seela S, Caldwell C, Boyer JL, Jain D: Liver biopsy: evolving role in the new millennium. J Clin Gastroenterol. 2005 Aug. PMID: 16000929

Seela S, Sheela H, Boyer JL: Autoimmune hepatitis type 1: safety and efficacy of prolonged medical therapy. Liver Int. 2005 Aug. PMID: 15998423

Denk GU, Soroka CJ, Mennone A, Koepsell H, Beuers U, Boyer JL: Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis. Hepatology. 2004 May. PMID: 15122767

Wang L, Boyer JL: The maintenance and generation of membrane polarity in hepatocytes. Hepatology. 2004 Apr. PMID: 15057889

Denk GU, Soroka CJ, Takeyama Y, Chen WS, Schuetz JD, Boyer JL: Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol. 2004 Apr. PMID: 15030973

Bohan A, Chen WS, Denson LA, Held MA, Boyer JL: Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis. J Biol Chem. 2003 Sep 19; 2003 Jul 1. PMID: 12837754

Cai SY, Soroka CJ, Ballatori N, Boyer JL: Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate. Am J Physiol Regul Integr Comp Physiol. 2003 Jan; 2002 Oct 3. PMID: 12388433

Wang L, Soroka CJ, Boyer JL: The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II. J Clin Invest. 2002 Oct. PMID: 12370274

Mennone A, Verkman AS, Boyer JL: Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. Am J Physiol Gastrointest Liver Physiol. 2002 Sep. PMID: 12181190

Denson LA, Bohan A, Held MA, Boyer JL: Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis. Gastroenterology. 2002 Aug. PMID: 12145812

Azzaroli F, Mehal W, Soroka CJ, Wang L, Lee J, Crispe IN, Boyer JL: Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. Hepatology. 2002 Jul. PMID: 12085348

Cai SY, Wang W, Soroka CJ, Ballatori N, Boyer JL: An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins. Am J Physiol Gastrointest Liver Physiol. 2002 Apr. PMID: 11897630

Bohan A, Boyer JL: Mechanisms of hepatic transport of drugs: implications for cholestatic drug reactions. Semin Liver Dis. 2002. PMID: 12016544

Lee J, Azzaroli F, Wang L, Soroka CJ, Gigliozzi A, Setchell KD, Kramer W, Boyer JL: Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology. 2001 Dec. PMID: 11729126

Singh SK, Mennone A, Gigliozzi A, Fraioli F, Boyer JL: Cl(-)-dependent secretory mechanisms in isolated rat bile duct epithelial units. Am J Physiol Gastrointest Liver Physiol. 2001 Aug. PMID: 11447024

Cai SY, Wang L, Ballatori N, Boyer JL: Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations. Am J Physiol Gastrointest Liver Physiol. 2001 Aug. PMID: 11447010

Soroka CJ, Lee JM, Azzaroli F, Boyer JL: Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology. 2001 Apr. PMID: 11283840

Mennone A, Biemesderfer D, Negoianu D, Yang CL, Abbiati T, Schultheis PJ, Shull GE, Aronson PS, Boyer JL: Role of sodium/hydrogen exchanger isoform NHE3 in fluid secretion and absorption in mouse and rat cholangiocytes. Am J Physiol Gastrointest Liver Physiol. 2001 Feb. PMID: 11208547

Gigliozzi A, Fraioli F, Sundaram P, Lee J, Mennone A, Alvaro D, Boyer JL: Molecular identification and functional characterization of Mdr1a in rat cholangiocytes. Gastroenterology. 2000 Oct. PMID: 11040198

Schlosser SF, Azzaroli F, Dao T, Hingorani R, Crispe IN, Boyer JL: Induction of murine hepatocyte death by membrane-bound CD95 (Fas/APO-1)-ligand: characterization of an in vitro system. Hepatology. 2000 Oct. PMID: 11003622

Dranoff JA, O'Neill AF, Franco AM, Cai SY, Connolly GC, Ballatori N, Boyer JL, Nathanson MH: A primitive ATP receptor from the little skate Raja erinacea. J Biol Chem. 2000 Sep 29. PMID: 10900200

Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL: Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology. 2000 Jan. PMID: 10611165

Lee J, Boyer JL: Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disorders. Semin Liver Dis. 2000. PMID: 11076403

Zheng TS, Schlosser SF, Dao T, Hingorani R, Crispe IN, Boyer JL, Flavell RA: Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc Natl Acad Sci U S A. 1998 Nov 10. PMID: 9811849

Arrese M, Trauner M, Ananthanarayanan M, Boyer JL, Suchy FJ: Maternal cholestasis does not affect the ontogenic pattern of expression of the Na+/taurocholate cotransporting polypeptide (ntcp) in the fetal and neonatal rat liver. Hepatology. 1998 Sep. PMID: 9731574

Crawford JM, Boyer JL: Clinicopathology conferences: inflammation-induced cholestasis. Hepatology. 1998 Jul. PMID: 9657120

Trauner M, Arrese M, Lee H, Boyer JL, Karpen SJ: Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest. 1998 May 15. PMID: 9593765

Koeppel TA, Trauner M, Mennone A, Arrese M, Rios-Velez L, Boyer JL: Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver. J Hepatol. 1998 May. PMID: 9625316

Roelofsen H, Soroka CJ, Keppler D, Boyer JL: Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J Cell Sci. 1998 Apr. PMID: 9512509

Boyer JL: Fish stories: 100 years at Mount Desert Island Biological Laboratory. Trans Am Clin Climatol Assoc. 1998. PMID: 9601129

Boyer JL: Isolated hepatocyte couplets and bile duct units--novel preparations for the in vitro study of bile secretory function. Cell Biol Toxicol. 1997 Jul. PMID: 9298249

Cho WK, Mennone A, Rydberg SA, Boyer JL: Bombesin stimulates bicarbonate secretion from rat cholangiocytes: implications for neural regulation of bile secretion. Gastroenterology. 1997 Jul. PMID: 9207292

Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, Suchy FJ, Keppler D, Boyer JL: The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology. 1997 Jul. PMID: 9207286

Trauner M, Nathanson MH, Rydberg SA, Koeppel TA, Gartung C, Sessa WC, Boyer JL: Endotoxin impairs biliary glutathione and HCO3- excretion and blocks the choleretic effect of nitric oxide in rat liver. Hepatology. 1997 May. PMID: 9141437

Gartung C, Schuele S, Schlosser SF, Boyer JL: Expression of the rat liver Na+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion. Hepatology. 1997 Feb. PMID: 9021935

Trauner M, Nathanson MH, Mennone A, Rydberg SA, Boyer JL: Nitric oxide donors stimulate bile flow and glutathione disulfide excretion independent of guanosine 3',5'-cyclic [corrected] monophosphate in the isolated perfused rat liver. Hepatology. 1997 Feb. PMID: 9021932

Nathanson MH, Burgstahler AD, Mennone A, Boyer JL: Characterization of cytosolic Ca2+ signaling in rat bile duct epithelia. Am J Physiol. 1996 Jul. PMID: 8760111

Boyer JL: Bile secretion--models, mechanisms, and malfunctions. A perspective on the development of modern cellular and molecular concepts of bile secretion and cholestasis. J Gastroenterol. 1996 Jun. PMID: 8726846

Beuers U, Throckmorton DC, Anderson MS, Isales CM, Thasler W, Kullak-Ublick GA, Sauter G, Koebe HG, Paumgartner G, Boyer JL: Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. Gastroenterology. 1996 May. PMID: 8613063

Boyer JL: Bile duct epithelium: frontiers in transport physiology. Am J Physiol. 1996 Jan. PMID: 8772494

Gartung C, Ananthanarayanan M, Rahman MA, Schuele S, Nundy S, Soroka CJ, Stolz A, Suchy FJ, Boyer JL: Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology. 1996 Jan. PMID: 8536857

Boyer JL, Soroka CJ: Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets. Gastroenterology. 1995 Nov. PMID: 7557144

Mennone A, Alvaro D, Cho W, Boyer JL: Isolation of small polarized bile duct units. Proc Natl Acad Sci U S A. 1995 Jul 3. PMID: 7541542

Chutaputti A, Burrell MI, Boyer JL: Pseudotumor of the pancreas associated with retroperitoneal fibrosis: a dramatic response to corticosteroid therapy. Am J Gastroenterol. 1995 Jul. PMID: 7611217

Felig DM, Brusilow SW, Boyer JL: Hyperammonemic coma due to parenteral nutrition in a woman with heterozygous ornithine transcarbamylase deficiency. Gastroenterology. 1995 Jul. PMID: 7797025

Ananthanarayanan M, Ng OC, Boyer JL, Suchy FJ: Characterization of cloned rat liver Na(+)-bile acid cotransporter using peptide and fusion protein antibodies. Am J Physiol. 1994 Oct. PMID: 7943329

Bruck R, Nathanson MH, Roelofsen H, Boyer JL: Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver. Hepatology. 1994 Oct. PMID: 7927205

Mahl TC, Shockcor W, Boyer JL: Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years. J Hepatol. 1994 Jun. PMID: 7930469

Boyer JL, Ng OC, Ananthanarayanan M, Hofmann AF, Schteingart CD, Hagenbuch B, Stieger B, Meier PJ: Expression and characterization of a functional rat liver Na+ bile acid cotransport system in COS-7 cells. Am J Physiol. 1994 Mar. PMID: 8166278

Benedetti A, Strazzabosco M, Ng OC, Boyer JL: Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes. Proc Natl Acad Sci U S A. 1994 Jan 18. PMID: 8290601

Beuers U, Nathanson MH, Isales CM, Boyer JL: Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. J Clin Invest. 1993 Dec. PMID: 8254052

Alvaro D, Mennone A, Boyer JL: Effect of ursodeoxycholic acid on intracellular pH regulation in isolated rat bile duct epithelial cells. Am J Physiol. 1993 Oct. PMID: 8238362

Alvaro D, Cho WK, Mennone A, Boyer JL: Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells. J Clin Invest. 1993 Sep. PMID: 8397224

Bruck R, Benedetti A, Strazzabosco M, Boyer JL: Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL. Am J Physiol. 1993 Aug. PMID: 8368316

Weinman SA, Graf J, Veith C, Boyer JL: Electroneutral uptake and electrogenic secretion of a fluorescent bile salt by rat hepatocyte couplets. Am J Physiol. 1993 Feb. PMID: 8447404

Beuers U, Nathanson MH, Boyer JL: Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes. Gastroenterology. 1993 Feb. PMID: 8425704

Nathanson MH, Gautam A, Ng OC, Bruck R, Boyer JL: Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets. Am J Physiol. 1992 Jun. PMID: 1616038

Sellinger M, Weinman SA, Henderson RM, Zweifach A, Boyer JL, Graf J: Anion channels in rat liver canalicular plasma membranes reconstituted into planar lipid bilayers. Am J Physiol. 1992 Jun. PMID: 1377450

Bruck R, Haddad P, Graf J, Boyer JL: Regulatory volume decrease stimulates bile flow, bile acid excretion, and exocytosis in isolated perfused rat liver. Am J Physiol. 1992 May. PMID: 1590390

Boyer JL, Graf J, Meier PJ: Hepatic transport systems regulating pHi, cell volume, and bile secretion. Annu Rev Physiol. 1992. PMID: 1562181

Nathanson MH, Gautam A, Bruck R, Isales CM, Boyer JL: Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology. 1992 Jan. PMID: 1727785

Boyer JL, Shockcor W, Mahl TC: The natural history of primary biliary cirrhosis. Trans Am Clin Climatol Assoc. 1992. PMID: 1413375

Benedetti A, Strazzabosco M, Corasanti JG, Haddad P, Graf J, Boyer JL: Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH. Am J Physiol. 1991 Sep. PMID: 1887897

Nathanson MH, Boyer JL: Mechanisms and regulation of bile secretion. Hepatology. 1991 Sep. PMID: 1874500

Haddad P, Beck JS, Boyer JL, Graf J: Role of chloride ions in liver cell volume regulation. Am J Physiol. 1991 Aug. PMID: 1872402

Strazzabosco M, Mennone A, Boyer JL: Intracellular pH regulation in isolated rat bile duct epithelial cells. J Clin Invest. 1991 May. PMID: 2022723

Strazzabosco M, Sakisaka S, Hayakawa T, Boyer JL: Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers. Am J Physiol. 1991 Jan. PMID: 1987808

Hayakawa T, Bruck R, Ng OC, Boyer JL: DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver. Am J Physiol. 1990 Nov. PMID: 2173414

Hayakawa T, Ng OC, Ma A, Boyer JL: Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver. Gastroenterology. 1990 Jul. PMID: 2344927

Fallon MB, Boyer JL: Hepatic toxicity of vitamin A and synthetic retinoids. J Gastroenterol Hepatol. 1990 May-Jun. PMID: 2103414

Graf J, Boyer JL: The use of isolated rat hepatocyte couplets in hepatobiliary physiology. J Hepatol. 1990 May. PMID: 2195112

Gleeson D, Corasanti JG, Boyer JL: Effects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH. Am J Physiol. 1990 Feb. PMID: 2305896

Corasanti JG, Gleeson D, Boyer JL: Effects of osmotic stresses on isolated rat hepatocytes. I. Ionic mechanisms of cell volume regulation. Am J Physiol. 1990 Feb. PMID: 2305895

Sellinger M, Barrett C, Malle P, Gordon ER, Boyer JL: Cryptic Na+,K(+)-ATPase activity in rat liver canalicular plasma membranes: evidence for its basolateral origin. Hepatology. 1990 Feb. PMID: 2155168

Corasanti JG, Smith ND, Gordon ER, Boyer JL: Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver. Hepatology. 1989 Jul. PMID: 2737605

Gleeson D, Smith ND, Boyer JL: Bicarbonate-dependent and -independent intracellular pH regulatory mechanisms in rat hepatocytes. Evidence for Na+-HCO3- cotransport. J Clin Invest. 1989 Jul. PMID: 2544626

Henderson RM, Graf J, Boyer JL: Inward-rectifying potassium channels in rat hepatocytes. Am J Physiol. 1989 Jun. PMID: 2735409

Anderson JM, Glade JL, Stevenson BR, Boyer JL, Mooseker MS: Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis. Am J Pathol. 1989 May. PMID: 2719075

Weinman SA, Graf J, Boyer JL: Voltage-driven, taurocholate-dependent secretion in isolated hepatocyte couplets. Am J Physiol. 1989 May. PMID: 2719107

Gautam A, Ng OC, Strazzabosco M, Boyer JL: Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry. J Clin Invest. 1989 Feb. PMID: 2913052

Boyer JL, Gautam A, Graf J: Mechanisms of bile secretion: insights from the isolated rat hepatocyte couplet. Semin Liver Dis. 1988 Nov. PMID: 2850606

Sakisaka S, Ng OC, Boyer JL: Tubulovesicular transcytotic pathway in isolated rat hepatocyte couplets in culture. Effect of colchicine and taurocholate. Gastroenterology. 1988 Sep. PMID: 3396824

Henderson RM, Krumpholz B, Boyer JL, Graf J: Effect of intracellular pH on potassium conductance in liver. Pflugers Arch. 1988 Aug. PMID: 3186436

Boyer JL: Definitive therapy for primary biliary cirrhosis--fact or fiction? Gastroenterology. 1988 Jul. PMID: 3371619

Ballatori N, Jacob R, Barrett C, Boyer JL: Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents. Am J Physiol. 1988 Jan. PMID: 2892423

Guzelian P, Boyer JL: Glucose reabsorption from bile. Evidence for a biliohepatic circulation. J Clin Invest. 1974 Feb. PMID: 11344566

Shi-Ying Cai, DSc

Li M, Cai SY, Boyer JL: Mechanisms of bile acid mediated inflammation in the liver. Mol Aspects Med. 2017 Aug; 2017 Jul 1. PMID: 28606651

Yu D, Zhang H, Lionarons DA, Boyer JL, Cai SY: Na+-taurocholate cotransporting polypeptide (NTCP/SLC10A1) ortholog in the marine skate Leucoraja erinacea is not a physiological bile salt transporter. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1; 2017 Jan 11. PMID: 28077388

Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL: Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714

Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL: Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study. J Clin Gastroenterol. 2017 Feb. PMID: 27428727

Cai SY, Boyer JL: The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage. Dig Dis. 2017; 2017 Mar 1. PMID: 28249287

Cai SY, Boyer JL: Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury. Inflamm Cell Signal. 2017; 2017 Jun 19. PMID: 28804737

Chai J, Cai SY, Liu X, Lian W, Chen S, Zhang L, Feng X, Cheng Y, He X, He Y, Chen L, Wang R, Wang H, Boyer JL, Chen W: Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. J Hepatol. 2015 Dec; 2015 Jul 23. PMID: 26212029

Yu DK, Zhang CX, Zhao SS, Zhang SH, Zhang H, Cai SY, Shao RG, He HW: The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway. Acta Pharmacol Sin. 2015 Apr; 2015 Mar 16. PMID: 25832428

Cai SY, Mennone A, Soroka CJ, Boyer JL: Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 2014 Jan 30. PMID: 24481602

Cai SY, Mennone A, Soroka CJ, Boyer JL: All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice. J Pharmacol Exp Ther. 2014 Apr; 2014 Feb 3. PMID: 24492652

Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL: Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology. 2013 Jun. PMID: 23175353

Lionarons DA, Boyer JL, Cai SY: Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2). J Lipid Res. 2012 Aug; 2012 Jun 5. PMID: 22669917

Cai SY, He H, Nguyen T, Mennone A, Boyer JL: Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms. J Lipid Res. 2010 Aug; 2010 Mar 25. PMID: 20338915

Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535

Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression. Hepatology. 2009 Nov. PMID: 19821532

Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL: ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology. 2009 Mar; 2008 Nov 1. PMID: 19027009

Cai SY, Xiong L, Wray CG, Ballatori N, Boyer JL: The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 2007 Jun 13. PMID: 17567710

Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL: Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Feb 1. PMID: 17272513

Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N: Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 2006 Jan 19. PMID: 16423920

Cai SY, Boyer JL: FXR: a target for cholestatic syndromes? Expert Opin Ther Targets. 2006 Jun. PMID: 16706681

Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL: Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology. 2006 May. PMID: 16628672

Denk GU, Cai SY, Chen WS, Lin A, Soroka CJ, Boyer JL: A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology. World J Gastroenterol. 2006 Apr 28. PMID: 16688799

Cai SY, Soroka CJ, Ballatori N, Boyer JL: Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate. Am J Physiol Regul Integr Comp Physiol. 2003 Jan; 2002 Oct 3. PMID: 12388433

Cai SY, Wang W, Soroka CJ, Ballatori N, Boyer JL: An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins. Am J Physiol Gastrointest Liver Physiol. 2002 Apr. PMID: 11897630

Cai SY, Wang L, Ballatori N, Boyer JL: Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations. Am J Physiol Gastrointest Liver Physiol. 2001 Aug. PMID: 11447010

Dranoff JA, O'Neill AF, Franco AM, Cai SY, Connolly GC, Ballatori N, Boyer JL, Nathanson MH: A primitive ATP receptor from the little skate Raja erinacea. J Biol Chem. 2000 Sep 29. PMID: 10900200

Cai SY, Babbitt RW, Marchesi VT: A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division. Proc Natl Acad Sci U S A. 1999 Mar 16. PMID: 10077596

Chuhan Chung, MD

Park JK, Shao M, Kim MY, Baik SK, Cho MY, Utsumi T, Satoh A, Ouyang X, Chung C, Iwakiri Y: An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization. Hepatology. 2017 May; 2017 Mar 22. PMID: 28090670

Gong J, Belinsky G, Sagheer U, Zhang X, Grippo PJ, Chung C: Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms. J Biol Chem. 2016 Oct 14; 2016 Aug 24. PMID: 27557659

Chung C, Insogna KL: The liver throws the skeleton a bone (resorption factor). Hepatology. 2016 Sep; 2016 Jul 25. PMID: 27312397

Belinsky GS, Sreekumar B, Andrejecsk JW, Saltzman WM, Gong J, Herzog RI, Lin S, Horsley V, Carpenter TO, Chung C: Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade. FASEB J. 2016 Aug; 2016 Apr 28. PMID: 27127101

Belinsky GS, Ward L, Chung C: Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI. Rare Dis. 2016; 2016 Jul 19. PMID: 27579219

Chung C, Gorelick FS: Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2016 May 24. PMID: 28090563

Principe DR, DeCant B, Diaz AM, Mangan RJ, Hwang R, Lowy A, Shetuni BB, Sreekumar BK, Chung C, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, Bishehsari F: PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction. Oncotarget. 2016 May 10. PMID: 27058416

Sagheer U, Gong J, Chung C: Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease. J Dev Biol. 2015 Dec; 2015 Nov 20. PMID: 27239449

Protiva P, Gong J, Sreekumar B, Torres R, Zhang X, Belinsky GS, Cornwell M, Crawford SE, Iwakiri Y, Chung C: Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver. Cell Mol Gastroenterol Hepatol. 2015 Sep 1; 2015 Jul 4. PMID: 26473164

Sreekumar BK, Belinsky GS, Einwachter H, Rhim AD, Schmid R, Chung C: Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions. Pancreas. 2014 Nov. PMID: 25072283

Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C: Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology. 2014 Apr; 2014 Jan 23. PMID: 24456163

Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, Chung C: Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content. FASEB J. 2013 Nov; 2013 Jul 25. PMID: 23887690

Chung C, Iwakiri Y: The lymphatic vascular system in liver diseases: its role in ascites formation. Clin Mol Hepatol. 2013 Jun; 2013 Jun 27. PMID: 23837133

Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y: Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice. Am J Pathol. 2013 Mar; 2013 Jan 9. PMID: 23313137

Chung C, Mader CC, Schmitz JC, Atladottir J, Fitchev P, Cornwell ML, Koleske AJ, Crawford SE, Gorelick F: The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer. Lab Invest. 2011 May; 2011 Feb 21. PMID: 21339745

Zhang D, Utsumi T, Huang HC, Gao L, Sangwung P, Chung C, Shibao K, Okamoto K, Yamaguchi K, Groszmann RJ, Jozsef L, Hao Z, Sessa WC, Iwakiri Y: Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis. Hepatology. 2011 Apr. PMID: 21480333

Chung C, Shugrue C, Nagar A, Doll JA, Cornwell M, Gattu A, Kolodecik T, Pandol SJ, Gorelick F: Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator. Gastroenterology. 2009 Jan; 2008 Oct 7. PMID: 18996124

Chung C, Doll JA, Gattu AK, Shugrue C, Cornwell M, Fitchev P, Crawford SE: Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL). J Hepatol. 2008 Mar; 2007 Dec 26. PMID: 18191271

Chung C, Doll JA, Stellmach VM, Gonzales J, Surapureddi S, Cornwell M, Reddy JK, Crawford SE: Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha. Adv Exp Med Biol. 2008. PMID: 18497086

Luca Fabris, MD, PhD

Carbone M, Cristoferi L, Cortesi PA, Rota M, Ciaccio A, Okolicsanyi S, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Belli LS, Munari LM, Mantovani L, Strazzabosco M: Optimising the clinical strategy for autoimmune liver diseases: Principles of value-based medicine. Biochim Biophys Acta. 2017 Aug 24; 2017 Aug 24. PMID: 28844954

Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M: Emerging concepts in biliary repair and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690

Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L: The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma. Biochim Biophys Acta. 2017 Jul 27; 2017 Jul 27. PMID: 28757170

Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L: Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium. Biochim Biophys Acta. 2017 Jul 25; 2017 Jul 25. PMID: 28754453

Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M: Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves CFTR correctors efficacy. Hepatology. 2017 Jul 24; 2017 Jul 24. PMID: 28836688

Mariotti V, Strazzabosco M, Fabris L, Calvisi DF: Animal models of biliary injury and altered bile acid metabolism. Biochim Biophys Acta. 2017 Jul 11; 2017 Jul 11. PMID: 28709963

Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M: Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057

Cadamuro M, Brivio S, Spirli C, Joplin RE, Strazzabosco M, Fabris L: Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma. Int J Mol Sci. 2017 Jan 13; 2017 Jan 13. PMID: 28098760

Cadamuro M, Spagnuolo G, Sambado L, Indraccolo S, Nardo G, Rosato A, Brivio S, Caslini C, Stecca T, Massani M, Bassi N, Novelli E, Spirli C, Fabris L, Strazzabosco M: Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma. Cancer Res. 2016 Aug 15; 2016 Jun 21. PMID: 27328733

Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M: Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994

Fabris L, Brivio S, Cadamuro M, Strazzabosco M: Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype. Stem Cells Int. 2016; 2016 Jan 6. PMID: 26880950

Brivio S, Cadamuro M, Fabris L, Strazzabosco M: Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma? J Clin Med. 2015 Dec 19; 2015 Dec 19. PMID: 26703747

Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M: Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562

Morton SD, Cadamuro M, Brivio S, Vismara M, Stecca T, Massani M, Bassi N, Furlanetto A, Joplin RE, Floreani A, Fabris L, Strazzabosco M: Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation. Oncotarget. 2015 Sep 22. PMID: 26296968

Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M: Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology. 2013 Nov; 2013 Sep 30. PMID: 23744610

Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M: Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. J Hepatol. 2013 Jul; 2013 Mar 7. PMID: 23500150

Strazzabosco M, Fabris L: The balance between Notch/Wnt signaling regulates progenitor cells' commitment during liver repair: mystery solved? J Hepatol. 2013 Jan; 2012 Aug 15. PMID: 22902547

Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M: Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib. Hepatology. 2012 Dec; 2012 Aug 27. PMID: 22653837

Strazzabosco M, Fabris L: Development of the bile ducts: essentials for the clinical hepatologist. J Hepatol. 2012 May; 2012 Jan 13. PMID: 22245898

Spirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M: Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes. Hepatology. 2012 Mar. PMID: 21987453

Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M: Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice. Gastroenterology. 2011 Oct; 2011 Jun 26. PMID: 21712022

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M: Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. Hepatology. 2010 May. PMID: 20131403

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M: ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology. 2010 Jan; 2009 Sep 18. PMID: 19766642

Strazzabosco M, Fabris L: Functional anatomy of normal bile ducts. Anat Rec (Hoboken). 2008 Jun. PMID: 18484611

Fiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M: Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion. Gastroenterology. 2007 Nov; 2007 Sep 2. PMID: 17983806

James J Farrell, MBChB

Xu MM, Yin S, Siddiqui AA, Salem RR, Schrope B, Sethi A, Poneros JM, Gress FG, Genkinger JM, Do C, Brooks CA, Chabot JA, Kluger MD, Kowalski T, Loren DE, Aslanian H, Farrell JJ, Gonda TA: Comparison of the diagnostic accuracy of three current guidelines for the evaluation of asymptomatic pancreatic cystic neoplasms. Medicine (Baltimore). 2017 Sep. PMID: 28858107

Ooka K, Rustagi T, Evans A, Farrell JJ: Surveillance and Outcomes of Nonresected Presumed Branch-Duct Intraductal Papillary Mucinous Neoplasms: A Meta-analysis. Pancreas. 2017 Aug. PMID: 28697134

Farrell JJ: Editorial: Stopping Pancreatic Cyst Surveillance? Am J Gastroenterol. 2017 Jul. PMID: 28725064

Farrell JJ: Pancreatic Cysts and Guidelines. Dig Dis Sci. 2017 Jul; 2017 May 20. PMID: 28528374

Farrell JJ: Response to Del Chiaro et al. Am J Gastroenterol. 2017 May. PMID: 28469214

Jiang Z, Luo HY, Farrell JJ, Zhang Z, Schulz VP, Albarawi D, Steinberg MH, Al-Allawi NA, Gallagher PG, Forget BG, Chui DH: A variant Sp1 (R218Q) transcription factor might enhance HbF expression in β0 -thalassaemia homozygotes. Br J Haematol. 2017 Feb 27; 2017 Feb 27. PMID: 28240767

Farrell JJ, Moughan J, Wong JL, Regine WF, Schaefer P, Benson AB 3rd, Macdonald JS, Liu X, Yen Y, Lai R, Zheng Z, Bepler G, Guha C, Elsaleh H: Precision Medicine and Pancreatic Cancer: A Gemcitabine Pathway Approach. Pancreas. 2016 Nov. PMID: 27748721

Farrell JJ: Poking the Pancreas: When to Needle that Incidental Cyst. Am J Gastroenterol. 2016 Oct; 2016 Sep 13. PMID: 27619834

Jiang Z, Luo HY, Huang S, Farrell JJ, Davis L, Théberge R, Benson KA, Riolueang S, Viprakasit V, Al-Allawi NA, Ünal S, Gümrük F, Akar N, Başak AN, Osorio L, Badens C, Pissard S, Joly P, Campbell AD, Gallagher PG, Steinberg MH, Forget BG, Chui DH: The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) β(0) -thalassaemia homozygotes. Br J Haematol. 2016 Mar; 2016 Jan 13. PMID: 26771086

Madhani K, Farrell JJ: Autoimmune Pancreatitis: An Update on Diagnosis and Management. Gastroenterol Clin North Am. 2016 Mar. PMID: 26895679

Shin EJ, Topazian M, Goggins MG, Syngal S, Saltzman JR, Lee JH, Farrell JJ, Canto MI: Linear-array EUS improves detection of pancreatic lesions in high-risk individuals: a randomized tandem study. Gastrointest Endosc. 2015 Nov; 2015 Apr 27. PMID: 25930097

Farrell JJ: Prevalence, Diagnosis and Management of Pancreatic Cystic Neoplasms: Current Status and Future Directions. Gut Liver. 2015 Sep 23. PMID: 26343068

Rustagi T, Farrell JJ: Endoscopic diagnosis and treatment of pancreatic neuroendocrine tumors. J Clin Gastroenterol. 2014 Nov-Dec. PMID: 24828360

Farrell JJ, Toste P, Wu N, Li L, Wong J, Malkhassian D, Tran LM, Wu X, Li X, Dawson D, Wu H, Donahue TR: Endoscopically acquired pancreatic cyst fluid microRNA 21 and 221 are associated with invasive cancer. Am J Gastroenterol. 2013 Aug; 2013 Jun 11. PMID: 23752880

Farrell JJ, Fernández-del Castillo C: Pancreatic cystic neoplasms: management and unanswered questions. Gastroenterology. 2013 Jun. PMID: 23622140

Romina Fiorotto, PhD

Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M: Emerging concepts in biliary repair and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690

Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L: The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma. Biochim Biophys Acta. 2017 Jul 27; 2017 Jul 27. PMID: 28757170

Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L: Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium. Biochim Biophys Acta. 2017 Jul 25; 2017 Jul 25. PMID: 28754453

Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M: Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves CFTR correctors efficacy. Hepatology. 2017 Jul 24; 2017 Jul 24. PMID: 28836688

Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M: Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057

Fiorotto R, Villani A, Kourtidis A, Scirpo R, Amenduni M, Geibel PJ, Cadamuro M, Spirli C, Anastasiadis PZ, Strazzabosco M: The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity. Hepatology. 2016 Dec; 2016 Oct 27. PMID: 27629435

Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M: Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994

Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M: Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562

Scirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M: Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium. Hepatology. 2015 Nov; 2015 Aug 28. PMID: 26199136

Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M: Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology. 2013 Nov; 2013 Sep 30. PMID: 23744610

Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M: Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. J Hepatol. 2013 Jul; 2013 Mar 7. PMID: 23500150

Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M: Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib. Hepatology. 2012 Dec; 2012 Aug 27. PMID: 22653837

Spirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M: Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes. Hepatology. 2012 Mar. PMID: 21987453

Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M: Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice. Gastroenterology. 2011 Oct; 2011 Jun 26. PMID: 21712022

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M: Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. Hepatology. 2010 May. PMID: 20131403

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M: ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology. 2010 Jan; 2009 Sep 18. PMID: 19766642

Strazzabosco M, Fiorotto R, Melero S, Glaser S, Francis H, Spirli C, Alpini G: Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Hepatology. 2009 Jul. PMID: 19444869

Fiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M: Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion. Gastroenterology. 2007 Nov; 2007 Sep 2. PMID: 17983806

Guadalupe Garcia-Tsao, MD

Albillos A, Zamora J, Martínez J, Arroyo D, Ahmad I, De-la-Peña J, Garcia-Pagán JC, Lo GH, Sarin S, Sharma B, Abraldes JG, Bosch J, Garcia-Tsao G, Baveno Cooperation.: Stratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta-analysis. Hepatology. 2017 Oct; 2017 Aug 26. PMID: 28543862

Garcia-Tsao G: Management of Acute Variceal Hemorrhage as a Model of Individualized Care for Patients With Cirrhosis. Clin Gastroenterol Hepatol. 2017 Sep 1; 2017 Sep 1. PMID: 28865767

Jangouk P, Turco L, De Oliveira A, Schepis F, Villa E, Garcia-Tsao G: Validating, deconstructing and refining Baveno criteria for ruling out high-risk varices in patients with compensated cirrhosis. Liver Int. 2017 Aug; 2017 Mar 7. PMID: 28160373

Wong F, O'Leary JG, Reddy KR, Garcia-Tsao G, Fallon MB, Biggins SW, Subramanian RM, Thuluvath PJ, Kamath PS, Patton H, Maliakkal B, Tandon P, Vargas H, Thacker L, Bajaj JS: Acute Kidney Injury in Cirrhosis: Baseline Serum Creatinine Predicts Patient Outcomes. Am J Gastroenterol. 2017 Jul; 2017 Apr 25. PMID: 28440305

Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J: Reply. Hepatology. 2017 Jul; 2017 May 27. PMID: 28342181

Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B: Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017 Jun 30; 2017 May 22. PMID: 28530644

Chizinga M, Rudkovskaia AA, Henderson K, Pollak J, Garcia-Tsao G, Young LH, Fares WH: Pulmonary Hypertension Prevalence and Prognosis in a Cohort of Patients with Hereditary Hemorrhagic Telangiectasia Undergoing Embolization of pAVMs. Am J Respir Crit Care Med. 2017 Apr 4; 2017 Apr 4. PMID: 28375020

Fortune BE, Ciarleglio M, Deng Y, Garcia-Tsao G: Reply to Risk Stratification in Acute Variceal Bleeding: Child-Pugh Versus Model for End-stage Liver Disease. J Clin Gastroenterol. 2017 Apr 3; 2017 Apr 3. PMID: 28375866

Bajaj JS, O'Leary JG, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Maliakkal B, Biggins SW, Thuluvath PJ, Fallon MB, Subramanian RM, Vargas HE, Lai J, Thacker LR, Reddy KR: Hepatic Encephalopathy Is Associated With Mortality in Patients With Cirrhosis Independent of Other Extrahepatic Organ Failures. Clin Gastroenterol Hepatol. 2017 Apr; 2016 Oct 5. PMID: 27720916

O'Leary JG, Wong F, Reddy KR, Garcia-Tsao G, Kamath PS, Biggins SW, Fallon MB, Subramanian RM, Maliakkal B, Thacker L, Bajaj JS: Gender-Specific Differences in Baseline, Peak, and Delta Serum Creatinine: The NACSELD Experience. Dig Dis Sci. 2017 Mar; 2016 Dec 26. PMID: 28025746

Shung DL, Garcia-Tsao G: Liver Capsule: Portal Hypertension and Varices: Pathogenesis, Stages, and Management. Hepatology. 2017 Mar; 2017 Feb 8. PMID: 28032650

Bianchini M, Pietri L, Garcia-Tsao G, Villa E: Reply. Hepatology. 2017 Feb; 2016 Nov 25. PMID: 27639187

Abraldes JG, Garcia-Tsao G: The Design of Clinical Trials in Portal Hypertension. Semin Liver Dis. 2017 Feb; 2017 Feb 15. PMID: 28201851

Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J: Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases. Hepatology. 2017 Jan; 2016 Dec 1. PMID: 27786365

Tandon P, Reddy KR, O'Leary JG, Garcia-Tsao G, Abraldes JG, Wong F, Biggins SW, Maliakkal B, Fallon MB, Subramanian RM, Thuluvath P, Kamath PS, Thacker LR, Bajaj JS, North American Consortium for the Study of End-Stage Liver Disease.: A Karnofsky performance status-based score predicts death after hospital discharge in patients with cirrhosis. Hepatology. 2017 Jan; 2016 Nov 29. PMID: 27775842

Garcia-Tsao G: Empowering women: Perspective from a hepatologist. Hepatology. 2016 Dec. PMID: 27770471

Garcia-Tsao G: The Child-Turcotte Classification: From Gestalt to Sophisticated Statistics and Back. Dig Dis Sci. 2016 Nov. PMID: 27696097

Garcia-Tsao G, Sack J: Reply. Hepatology. 2016 Nov; 2016 May 17. PMID: 27112971

Balakrishnan M, Souza F, Muñoz C, Augustin S, Loo N, Deng Y, Ciarleglio M, Garcia-Tsao G: Liver and Spleen Stiffness Measurements by Point Shear Wave Elastography via Acoustic Radiation Force Impulse: Intraobserver and Interobserver Variability and Predictors of Variability in a US Population. J Ultrasound Med. 2016 Nov; 2016 Sep 23. PMID: 27663656

Fortune BE, Garcia-Tsao G, Ciarleglio M, Deng Y, Fallon MB, Sigal S, Chalasani NP, Lim JK, Reuben A, Vargas HE, Abrams G, Lewis MD, Hassanein T, Trotter JF, Sanyal AJ, Beavers KL, Ganger D, Thuluvath PJ, Grace ND, Groszmann RJ, Vapreotide Study Group.: Child-Turcotte-Pugh Class is Best at Stratifying Risk in Variceal Hemorrhage: Analysis of a US Multicenter Prospective Study. J Clin Gastroenterol. 2016 Oct 24; 2016 Oct 24. PMID: 27779613

De Pietri L, Bianchini M, Garcia-Tsao G, Villa E: Reply. Hepatology. 2016 Sep; 2016 Feb 19. PMID: 26705089

Tate JP, Mohanty A, Garcia-Tsao G: Reply. Gastroenterology. 2016 Aug; 2016 Jul 1. PMID: 27376519

Njei B, McCarty TR, Garcia-Tsao G: Beta-blockers in patients with cirrhosis and ascites: type of beta-blocker matters. Gut. 2016 Aug; 2016 May 20. PMID: 27207973

De Pietri L, Bianchini M, Garcia-Tsao G, Villa E: Reply. Hepatology. 2016 Aug; 2016 Jan 8. PMID: 26547626

Tandon P, Ripoll C, Assis D, Wongcharatrawee S, Groszmann RJ, Garcia-Tsao G: The interpretation of hepatic venous pressure gradient tracings - excellent interobserver agreement unrelated to experience. Liver Int. 2016 Aug; 2016 Feb 8. PMID: 26763558

Bajaj JS, Reddy KR, Tandon P, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Biggins SW, Thuluvath PJ, Fallon MB, Subramanian RM, Vargas H, Thacker LR, O'Leary JG, North American Consortium for the Study of End-Stage Liver Disease.: The 3-month readmission rate remains unacceptably high in a large North American cohort of patients with cirrhosis. Hepatology. 2016 Jul; 2016 Feb 19. PMID: 26690389

Arroyo V, Moreau R, Kamath PS, Jalan R, Ginès P, Nevens F, Fernández J, To U, García-Tsao G, Schnabl B: Acute-on-chronic liver failure in cirrhosis. Nat Rev Dis Primers. 2016 Jun 9; 2016 Jun 9. PMID: 27277335

Fernández J, Tandon P, Mensa J, Garcia-Tsao G: Antibiotic prophylaxis in cirrhosis: Good and bad. Hepatology. 2016 Jun; 2016 Jan 11. PMID: 26528864

Fraenkel L, Lim J, Garcia-Tsao G, Reyna V, Monto A, Bridges JF: Variation in Treatment Priorities for Chronic Hepatitis C: A Latent Class Analysis. Patient. 2016 Jun. PMID: 26518200

Barr RG, Ferraioli G, Palmeri ML, Goodman ZD, Garcia-Tsao G, Rubin J, Garra B, Myers RP, Wilson SR, Rubens D, Levine D: Elastography Assessment of Liver Fibrosis: Society of Radiologists in Ultrasound Consensus Conference Statement. Ultrasound Q. 2016 Jun. PMID: 27233069

Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS: Corrigendum to "Management of the critically ill patients with cirrhosis: A multidisciplinary perspective". J Hepatol. 2016 May 27; 2016 May 27. PMID: 27241199

Sack J, Garcia-Tsao G: Variceal Hemorrhage in a Patient With Hepatitis C Virus Cirrhosis in Whom Liver Synthetic Function had Normalized After Viral Elimination. Hepatology. 2016 May; 2016 Mar 10. PMID: 26806550

Fraenkel L, Lim J, Garcia-Tsao G, Reyna V, Monto A: Examining Hepatitis C Virus Treatment Preference Heterogeneity Using Segmentation Analysis: Treat Now or Defer? J Clin Gastroenterol. 2016 Mar. PMID: 26166145

Garcia-Tsao G: Beta blockers in cirrhosis: The window re-opens. J Hepatol. 2016 Mar; 2015 Dec 24. PMID: 26724557

Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS: Management of the critically ill patient with cirrhosis: A multidisciplinary perspective. J Hepatol. 2016 Mar; 2015 Oct 28. PMID: 26519602

Mohanty A, Tate JP, Garcia-Tsao G: Statins Are Associated With a Decreased Risk of Decompensation and Death in Veterans With Hepatitis C-Related Compensated Cirrhosis. Gastroenterology. 2016 Feb; 2015 Oct 17. PMID: 26484707

De Pietri L, Bianchini M, Montalti R, De Maria N, Di Maira T, Begliomini B, Gerunda GE, di Benedetto F, Garcia-Tsao G, Villa E: Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: A randomized, controlled trial. Hepatology. 2016 Feb; 2015 Dec 9. PMID: 26340411

Garcia-Tsao G: Current Management of the Complications of Cirrhosis and Portal Hypertension: Variceal Hemorrhage, Ascites, and Spontaneous Bacterial Peritonitis. Dig Dis. 2016; 2016 May 11. PMID: 27170392

Yan K, Garcia-Tsao G: Novel prevention strategies for bacterial infections in cirrhosis. Expert Opin Pharmacother. 2016; 2016 Feb 23. PMID: 26799197

Garcia-Tsao G, Bosch J: Varices and Variceal Hemorrhage in Cirrhosis: A New View of an Old Problem. Clin Gastroenterol Hepatol. 2015 Nov; 2015 Jul 17. PMID: 26192141

Barr RG, Ferraioli G, Palmeri ML, Goodman ZD, Garcia-Tsao G, Rubin J, Garra B, Myers RP, Wilson SR, Rubens D, Levine D: Elastography Assessment of Liver Fibrosis: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology. 2015 Sep; 2015 Jun 16. PMID: 26079489

Ripoll C, Bari K, Garcia-Tsao G: Serum Albumin Can Identify Patients With Compensated Cirrhosis With a Good Prognosis. J Clin Gastroenterol. 2015 Aug. PMID: 25203362

Balakrishnan M, Garcia-Tsao G, Deng Y, Ciarleglio M, Jain D: Hepatic arteriolosclerosis: a small-vessel complication of diabetes and hypertension. Am J Surg Pathol. 2015 Jul. PMID: 25786083

Bhutta AQ, Garcia-Tsao G: The Role of Medical Therapy for Variceal Bleeding. Gastrointest Endosc Clin N Am. 2015 Jul; 2015 Apr 20. PMID: 26142033

Reddy KR, O'Leary JG, Kamath PS, Fallon MB, Biggins SW, Wong F, Patton HM, Garcia-Tsao G, Subramanian RM, Thacker LR, Bajaj JS, North American Consortium for the Study of End-Stage Liver Disease.: High risk of delisting or death in liver transplant candidates following infections: Results from the North American Consortium for the Study of End-Stage Liver Disease. Liver Transpl. 2015 Jul. PMID: 25845966

Yan K, Bridges JF, Augustin S, Laine L, Garcia-Tsao G, Fraenkel L: Factors impacting physicians' decisions to prevent variceal hemorrhage. BMC Gastroenterol. 2015 May 2; 2015 May 2. PMID: 25934271

O'Leary JG, Reddy KR, Wong F, Kamath PS, Patton HM, Biggins SW, Fallon MB, Garcia-Tsao G, Subramanian RM, Malik R, Thacker LR, Bajaj JS, North American Consortium for the Study of End-Stage Liver Disease.: Long-term use of antibiotics and proton pump inhibitors predict development of infections in patients with cirrhosis. Clin Gastroenterol Hepatol. 2015 Apr; 2014 Aug 12. PMID: 25130937

Mohanty A, Garcia-Tsao G: Hyponatremia and Hepatorenal Syndrome. Gastroenterol Hepatol (N Y). 2015 Apr. PMID: 27099594

Angeli P, Gines P, Wong F, Bernardi M, Boyer TD, Gerbes A, Moreau R, Jalan R, Sarin SK, Piano S, Moore K, Lee SS, Durand F, Salerno F, Caraceni P, Kim WR, Arroyo V, Garcia-Tsao G, International Club of Ascites.: Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites. Gut. 2015 Apr; 2015 Jan 28. PMID: 25631669

Angeli P, Ginès P, Wong F, Bernardi M, Boyer TD, Gerbes A, Moreau R, Jalan R, Sarin SK, Piano S, Moore K, Lee SS, Durand F, Salerno F, Caraceni P, Kim WR, Arroyo V, Garcia-Tsao G: Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites. J Hepatol. 2015 Apr; 2015 Jan 28. PMID: 25638527

Wong F, O'Leary JG, Reddy KR, Kamath PS, Garcia-Tsao G, Maliakkal B, Subramanian R, Thacker L, Bajaj J, North American Consortium for the Study of End-Stage Liver Disease.: A cut-off serum creatinine value of 1.5 mg/dl for AKI--to be or not to be. J Hepatol. 2015 Mar; 2014 Dec 5. PMID: 25485798

Belcher JM, Garcia-Tsao G, Sanyal AJ, Thiessen-Philbrook H, Peixoto AJ, Perazella MA, Ansari N, Lim J, Coca SG, Parikh CR, TRIBE-AKI Consortium.: Urinary biomarkers and progression of AKI in patients with cirrhosis. Clin J Am Soc Nephrol. 2014 Nov 7; 2014 Sep 2. PMID: 25183658

Belcher JM, Sanyal AJ, Peixoto AJ, Perazella MA, Lim J, Thiessen-Philbrook H, Ansari N, Coca SG, Garcia-Tsao G, Parikh CR, TRIBE-AKI Consortium.: Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology. 2014 Aug; 2014 Jun 26. PMID: 24375576

Jalan R, Fernandez J, Wiest R, Schnabl B, Moreau R, Angeli P, Stadlbauer V, Gustot T, Bernardi M, Canton R, Albillos A, Lammert F, Wilmer A, Mookerjee R, Vila J, Garcia-Martinez R, Wendon J, Such J, Cordoba J, Sanyal A, Garcia-Tsao G, Arroyo V, Burroughs A, Ginès P: Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol. 2014 Jun; 2014 Feb 12. PMID: 24530646

Fortune B, Garcia-Tsao G: Current Management Strategies for Acute Esophageal Variceal Hemorrhage. Curr Hepatol Rep. 2014 Mar 1. PMID: 24955303

Belcher JM, Sanyal AJ, Garcia-Tsao G, Ansari N, Coca SG, Shlipak MG, Parikh CR: Early trends in cystatin C and outcomes in patients with cirrhosis and acute kidney injury. Int J Nephrol. 2014; 2014 Mar 18. PMID: 24757564

Belcher JM, Parikh CR, Garcia-Tsao G: Acute kidney injury in patients with cirrhosis: perils and promise. Clin Gastroenterol Hepatol. 2013 Dec; 2013 Apr 10. PMID: 23583467

Chander Roland B, Garcia-Tsao G, Ciarleglio MM, Deng Y, Sheth A: Decompensated cirrhotics have slower intestinal transit times as compared with compensated cirrhotics and healthy controls. J Clin Gastroenterol. 2013 Nov-Dec. PMID: 23632359

Loo NM, Souza FF, Garcia-Tsao G: Non-hemorrhagic acute complications associated with cirrhosis and portal hypertension. Best Pract Res Clin Gastroenterol. 2013 Oct; 2013 Sep 5. PMID: 24160926

Young LH, Henderson KJ, White RI, Garcia-Tsao G: Bevacizumab: finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia. Hepatology. 2013 Jul; 2013 May 31. PMID: 23686865

Bedossa P, Garcia-Tsao G, Jain D: Cirrhosis Regression and Subclassification. Surg Pathol Clin. 2013 Jun; 2013 Apr 26. PMID: 26838976

Belcher JM, Garcia-Tsao G, Sanyal AJ, Bhogal H, Lim JK, Ansari N, Coca SG, Parikh CR, TRIBE-AKI Consortium.: Association of AKI with mortality and complications in hospitalized patients with cirrhosis. Hepatology. 2013 Feb; 2012 Dec 6. PMID: 22454364

Bari K, Miñano C, Shea M, Inayat IB, Hashem HJ, Gilles H, Heuman D, Garcia-Tsao G: The combination of octreotide and midodrine is not superior to albumin in preventing recurrence of ascites after large-volume paracentesis. Clin Gastroenterol Hepatol. 2012 Oct; 2012 Jul 16. PMID: 22801062

Sethasine S, Jain D, Groszmann RJ, Garcia-Tsao G: Quantitative histological-hemodynamic correlations in cirrhosis. Hepatology. 2012 Apr. PMID: 22109744

Bari K, Garcia-Tsao G: Treatment of portal hypertension. World J Gastroenterol. 2012 Mar 21. PMID: 22468079

Opio CK, Garcia-Tsao G: Managing varices: drugs, bands, and shunts. Gastroenterol Clin North Am. 2011 Sep. PMID: 21893274

Tandon P, Garcia-Tsao G: Renal dysfunction is the most important independent predictor of mortality in cirrhotic patients with spontaneous bacterial peritonitis. Clin Gastroenterol Hepatol. 2011 Mar; 2010 Dec 8. PMID: 21145427

Miñano C, Garcia-Tsao G: Clinical pharmacology of portal hypertension. Gastroenterol Clin North Am. 2010 Sep. PMID: 20951924

Tandon P, Inayat I, Tal M, Spector M, Shea M, Groszmann RJ, Garcia-Tsao G: Sildenafil has no effect on portal pressure but lowers arterial pressure in patients with compensated cirrhosis. Clin Gastroenterol Hepatol. 2010 Jun; 2010 Feb 6. PMID: 20144739

Garcia-Tsao G, Friedman S, Iredale J, Pinzani M: Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis. Hepatology. 2010 Apr. PMID: 20077563

Garcia-Tsao G, Bosch J: Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med. 2010 Mar 4. PMID: 20200386

Fraenkel L, Chodkowski D, Lim J, Garcia-Tsao G: Patients' preferences for treatment of hepatitis C. Med Decis Making. 2010 Jan-Feb; 2009 Jul 27. PMID: 19636065

Khalid SK, Lane J, Navarro V, Garcia-Tsao G: Use of over-the-counter analgesics is not associated with acute decompensation in patients with cirrhosis. Clin Gastroenterol Hepatol. 2009 Sep; 2009 Apr 24. PMID: 19394441

Garcia-Tsao G, Lim JK, Members of Veterans Affairs Hepatitis C Resource Center Program.: Management and treatment of patients with cirrhosis and portal hypertension: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program. Am J Gastroenterol. 2009 Jul; 2009 May 19. PMID: 19455106

Tandon P, Garcia-Tsao G: Prognostic indicators in hepatocellular carcinoma: a systematic review of 72 studies. Liver Int. 2009 Apr; 2008 Dec 24. PMID: 19141028

Garcia-Tsao G, Parikh CR, Viola A: Acute kidney injury in cirrhosis. Hepatology. 2008 Dec. PMID: 19003880

Khalid SK, Garcia-Tsao G: Hepatic vascular malformations in hereditary hemorrhagic telangiectasia. Semin Liver Dis. 2008 Aug; 2008 Sep 23. PMID: 18814078

Sheth AA, Garcia-Tsao G: Probiotics and liver disease. J Clin Gastroenterol. 2008 Jul. PMID: 18542037

Floch MH, Walker WA, Guandalini S, Hibberd P, Gorbach S, Surawicz C, Sanders ME, Garcia-Tsao G, Quigley EM, Isolauri E, Fedorak RN, Dieleman LA: Recommendations for probiotic use--2008. J Clin Gastroenterol. 2008 Jul. PMID: 18542033

Garcia-Tsao G, Bosch J, Groszmann RJ: Portal hypertension and variceal bleeding--unresolved issues. Summary of an American Association for the study of liver diseases and European Association for the study of the liver single-topic conference. Hepatology. 2008 May. PMID: 18435460

Longacre AV, Imaeda A, Garcia-Tsao G, Fraenkel L: A pilot project examining the predicted preferences of patients and physicians in the primary prophylaxis of variceal hemorrhage. Hepatology. 2008 Jan. PMID: 17935182

Ripoll C, Garcia-Tsao G: Treatment of gastropathy and gastric antral vascular ectasia in patients with portal hypertension. Curr Treat Options Gastroenterol. 2007 Dec. PMID: 18221609

Garcia-Tsao G: Preventing the development of varices in cirrhosis. J Clin Gastroenterol. 2007 Nov-Dec. PMID: 17975480

Garcia-Tsao G, Nathanson MH: Portal hypertension: from the patient to the molecule and back: a symposium honoring Roberto J. Groszmann, MD. J Clin Gastroenterol. 2007 Nov-Dec. PMID: 17975470

Garcia-Tsao G, Sanyal AJ, Grace ND, Carey WD, Practice Guidelines Committee of American Association for Study of Liver Diseases., Practice Parameters Committee of American College of Gastroenterology.: Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Am J Gastroenterol. 2007 Sep. PMID: 17727436

Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W, Practice Guidelines Committee of the American Association for the Study of Liver Diseases., Practice Parameters Committee of the American College of Gastroenterology.: Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007 Sep. PMID: 17879356

Ripoll C, Groszmann R, Garcia-Tsao G, Grace N, Burroughs A, Planas R, Escorsell A, Garcia-Pagan JC, Makuch R, Patch D, Matloff DS, Bosch J, Portal Hypertension Collaborative Group.: Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis. Gastroenterology. 2007 Aug; 2007 May 21. PMID: 17681169

Garcia-Tsao G: Liver involvement in hereditary hemorrhagic telangiectasia (HHT). J Hepatol. 2007 Mar; 2007 Jan 2. PMID: 17239481

Ghassemi S, Garcia-Tsao G: Prevention and treatment of infections in patients with cirrhosis. Best Pract Res Clin Gastroenterol. 2007. PMID: 17223498

Garcia-Tsao G, Gish RG, Punch J: Model for end-stage liver disease (MELD) exception for hereditary hemorrhagic telangiectasia. Liver Transpl. 2006 Dec. PMID: 17123286

Wu JS, Saluja S, Garcia-Tsao G, Chong A, Henderson KJ, White RI Jr: Liver involvement in hereditary hemorrhagic telangiectasia: CT and clinical findings do not correlate in symptomatic patients. AJR Am J Roentgenol. 2006 Oct. PMID: 16985112

Longacre AV, Garcia-Tsao G: A commonsense approach to esophageal varices. Clin Liver Dis. 2006 Aug. PMID: 17162231

Garcia-Tsao G: The transjugular intrahepatic portosystemic shunt for the management of cirrhotic refractory ascites. Nat Clin Pract Gastroenterol Hepatol. 2006 Jul. PMID: 16819501

Fraenkel L, McGraw S, Wongcharatrawee S, Garcia-Tsao G: Patients' experiences related to anti-viral treatment for hepatitis C. Patient Educ Couns. 2006 Jul; 2005 Aug 10. PMID: 16098705

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2006 May. PMID: 16550040

Chainuvati S, Khalid SK, Kancir S, Shea M, Edwards J, Sernyak M, Wongcharatrawee S, Garcia-Tsao G: Comparison of hepatitis C treatment patterns in patients with and without psychiatric and/or substance use disorders. J Viral Hepat. 2006 Apr. PMID: 16611189

Nagula S, Jain D, Groszmann RJ, Garcia-Tsao G: Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis. J Hepatol. 2006 Jan; 2005 Sep 23. PMID: 16274836

Fraenkel L, McGraw S, Wongcharatrawee S, Garcia-Tsao G: What do patients consider when making decisions about treatment for hepatitis C? Am J Med. 2005 Dec. PMID: 16378783

Garcia-Tsao G: Transjugular intrahepatic portosystemic shunt in the management of refractory ascites. Semin Intervent Radiol. 2005 Dec. PMID: 21326706

Groszmann RJ, Garcia-Tsao G, Bosch J, Grace ND, Burroughs AK, Planas R, Escorsell A, Garcia-Pagan JC, Patch D, Matloff DS, Gao H, Makuch R, Portal Hypertension Collaborative Group.: Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med. 2005 Nov 24. PMID: 16306522

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2005 May. PMID: 15818152

Garcia-Tsao G: Bacterial infections in cirrhosis: treatment and prophylaxis. J Hepatol. 2005; 2005 Jan 18. PMID: 15777576

Garcia-Tsao G: Refractory ascites and hepatorenal syndrome. Rev Gastroenterol Mex. 2004 Nov. PMID: 16881221

Garcia-Tsao G: Spontaneous bacterial peritonitis: a historical perspective. J Hepatol. 2004 Oct. PMID: 15464231

Garcia-Tsao G: Bacterial infections in cirrhosis. Can J Gastroenterol. 2004 Jun. PMID: 15190398

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2004 May. PMID: 15703650

Garcia-Tsao G, Wiest R: Gut microflora in the pathogenesis of the complications of cirrhosis. Best Pract Res Clin Gastroenterol. 2004 Apr. PMID: 15123075

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2003 May. PMID: 15703565

Garcia-Tsao G, Bassin L: Difficult management decision. J Clin Gastroenterol. 2002 Nov-Dec. PMID: 12394218

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2002 May. PMID: 17033306

Tang LH, Hui P, Garcia-Tsao G, Salem RR, Jain D: Multiple angiomyolipomata of the liver: a case report. Mod Pathol. 2002 Feb. PMID: 11850546

Wongcharatrawee S, Garcia-Tsao G: Clinical management of ascites and its complications. Clin Liver Dis. 2001 Aug. PMID: 11565143

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2001 May. PMID: 17031170

Garcia-Tsao G: Current management of the complications of cirrhosis and portal hypertension: variceal hemorrhage, ascites, and spontaneous bacterial peritonitis. Gastroenterology. 2001 Feb. PMID: 11179247

Garcia-Tsao G: Treatment of refractory ascites: tips or taps? Hepatology. 2001 Feb. PMID: 11172354

Garcia-Tsao G, Korzenik JR, Young L, Henderson KJ, Jain D, Byrd B, Pollak JS, White RI Jr: Liver disease in patients with hereditary hemorrhagic telangiectasia. N Engl J Med. 2000 Sep 28. PMID: 11006369

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 2000 May. PMID: 17023887

Garcia-Tsao G: Portal hypertension. Curr Opin Gastroenterol. 1999 May. PMID: 17023954

Steinlauf AF, Garcia-Tsao G, Zakko MF, Dickey K, Gupta T, Groszmann RJ: Low-dose midazolam sedation: an option for patients undergoing serial hepatic venous pressure measurements. Hepatology. 1999 Apr. PMID: 10094948

Kuan SF, Garcia-Tsao G, Cartun RW, Emanuel JR, West AB: Viral RNA in duodenal bile of cirrhotic patients with chronic hepatitis C. Arch Pathol Lab Med. 1997 Aug. PMID: 9278613

Taylor CR, Garcia-Tsao G, Henson B, Case CQ, Taylor KJ: Doppler ultrasound in the evaluation of cirrhotic patients: the prevalence of intrahepatic arteriovenous shunting, and implications for diagnosis of hepatocellular carcinoma. Ultrasound Med Biol. 1997. PMID: 9372563

García-Tsao G: [Gastroesophageal varices hemorrhage: non-surgical treatment]. Rev Gastroenterol Mex. 1996 Oct-Dec. PMID: 9102789

García-Tsao G: Treatment of chronic hepatitis C. Rev Gastroenterol Mex. 1995 Oct-Dec. PMID: 8948779

Navarro VJ, Garcia-Tsao G: Variceal hemorrhage. Crit Care Clin. 1995 Apr. PMID: 7788538

Garcia-Tsao G: Cirrhotic ascites: pathogenesis and management. Gastroenterologist. 1995 Mar. PMID: 7743121

Garcia-Tsao G: Spontaneous bacterial peritonitis. Gastroenterol Clin North Am. 1992 Mar. PMID: 1568776

Garcia-Tsao G, Panzini L, Yoselevitz M, West AB: Bacillary peliosis hepatis as a cause of acute anemia in a patient with the acquired immunodeficiency syndrome. Gastroenterology. 1992 Mar. PMID: 1537498

Conn HO, Grace ND, Bosch J, Groszmann RJ, Rodés J, Wright SC, Matloff DS, Garcia-Tsao G, Fisher RL, Navasa M: Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial. The Boston-New Haven-Barcelona Portal Hypertension Study Group. Hepatology. 1991 May. PMID: 2029994

Garcia-Tsao G: Treatment of ascites with a single total paracentesis. Hepatology. 1991 May. PMID: 2029984

Fred Gorelick, MD

Bustos V, Pulina MV, Kelahmetoglu Y, Sinha SC, Gorelick FS, Flajolet M, Greengard P: Bidirectional regulation of Aβ levels by Presenilin 1. Proc Natl Acad Sci U S A. 2017 Jul 3; 2017 May 22. PMID: 28533411

Bustos V, Pulina MV, Bispo A, Lam A, Flajolet M, Gorelick FS, Greengard P: Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2017 Jul 3; 2017 May 22. PMID: 28533369

Gorelick FS, Lerch MM: Do Animal Models of Acute Pancreatitis Reproduce Human Disease? Cell Mol Gastroenterol Hepatol. 2017 Sep; 2017 Jun 10. PMID: 28752114

Gorelick FS: Advances in pancreatology: 2016. Curr Opin Gastroenterol. 2016 Jul 21; 2016 Jul 21. PMID: 27454030

Chung C, Gorelick FS: Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2016 May 24. PMID: 28090563

Srinivasan P, Thrower EC, Gorelick FS, Said HM: Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Am J Physiol Gastrointest Liver Physiol. 2016 May 15; 2016 Mar 17. PMID: 26999808

Srinivasan P, Thrower EC, Loganathan G, Balamurugan AN, Subramanian VS, Gorelick FS, Said HM: Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells. PLoS One. 2015; 2015 Dec 3. PMID: 26633299

Messenger SW, Thomas DD, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE: Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells. Cell Mol Gastroenterol Hepatol. 2015 Nov 1. PMID: 26618189

Reed AM, Kolodecik T, Husain SZ, Gorelick FS: Low pH enhances connexin32 degradation in the pancreatic acinar cell. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1; 2014 May 8. PMID: 24812055

Alexandre M, Uduman AK, Minervini S, Raoof A, Shugrue CA, Akinbiyi EO, Patel V, Shitia M, Kolodecik TR, Patton R, Gorelick FS, Thrower EC: Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 2012 Jul 26. PMID: 22837343

Shugrue CA, Alexandre M, Diaz de Villalvilla A, Kolodecik TR, Young LH, Gorelick FS, Thrower EC: Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 2012 Jul 19. PMID: 22821946

Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS: Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. PLoS One. 2012; 2012 Jul 23. PMID: 22844459

Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH: Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling. J Biol Chem. 2011 Jan 21; 2010 Nov 17. PMID: 21084290

Alexandre M, Pandol SJ, Gorelick FS, Thrower EC: The emerging role of smoking in the development of pancreatitis. Pancreatology. 2011; 2011 Oct 5. PMID: 21986098

Thrower EC, Gorelick FS, Husain SZ: Molecular and cellular mechanisms of pancreatic injury. Curr Opin Gastroenterol. 2010 Sep. PMID: 20651589

Gorelick FS, Thrower E: The acinar cell and early pancreatitis responses. Clin Gastroenterol Hepatol. 2009 Nov. PMID: 19896090

Thrower EC, Wang J, Cheriyan S, Lugea A, Kolodecik TR, Yuan J, Reeve JR Jr, Gorelick FS, Pandol SJ: Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini. Pancreas. 2009 Nov. PMID: 19752773

Bhoomagoud M, Jung T, Atladottir J, Kolodecik TR, Shugrue C, Chaudhuri A, Thrower EC, Gorelick FS: Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats. Gastroenterology. 2009 Sep; 2009 May 18. PMID: 19454288

Thrower EC, Osgood S, Shugrue CA, Kolodecik TR, Chaudhuri AM, Reeve JR Jr, Pandol SJ, Gorelick FS: The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2008 Jun; 2008 Apr 3. PMID: 18388183

Husain SZ, Grant WM, Gorelick FS, Nathanson MH, Shah AU: Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 2007 Mar 1. PMID: 17332472

Chaudhuri A, Husain SZ, Kolodecik TR, Grant WM, Gorelick FS: Cyclic AMP-dependent protein kinase and Epac mediate cyclic AMP responses in pancreatic acini. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Jan 18. PMID: 17234888

Gorelick FS, Shugrue CA, Kolodecik TR, Thrower EC: Vacuolar adenosine triphosphatase and pancreatic acinar cell function. J Gastroenterol Hepatol. 2006 Oct. PMID: 16958663

Thrower EC, Diaz de Villalvilla AP, Kolodecik TR, Gorelick FS: Zymogen activation in a reconstituted pancreatic acinar cell system. Am J Physiol Gastrointest Liver Physiol. 2006 May; 2005 Dec 8. PMID: 16339296

Husain SZ, Prasad P, Grant WM, Kolodecik TR, Nathanson MH, Gorelick FS: The ryanodine receptor mediates early zymogen activation in pancreatitis. Proc Natl Acad Sci U S A. 2005 Oct 4; 2005 Sep 26. PMID: 16186498

Nagar AB, Gorelick FS: Acute pancreatitis. Curr Opin Gastroenterol. 2004 Sep. PMID: 15689676

Gorelick FS: Alcohol and zymogen activation in the pancreatic acinar cell. Pancreas. 2003 Nov. PMID: 14576492

Chakrabarti S, Kobayashi KS, Flavell RA, Marks CB, Miyake K, Liston DR, Fowler KT, Gorelick FS, Andrews NW: Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J Cell Biol. 2003 Aug 18. PMID: 12925704

Gorelick FS: Pancreas cell physiology and pancreatitis cell biology. Summary of a symposium held at the joint meeting of the EPC and the IAP, Heidelberg 2002. Pancreatology. 2003. PMID: 12771516

Nagar AB, Gorelick FS: Acute pancreatitis. Curr Opin Gastroenterol. 2002 Sep. PMID: 17033332

Gorelick FS, Shugrue C: Exiting the endoplasmic reticulum. Mol Cell Endocrinol. 2001 May 25. PMID: 11377815

Karne S, Gorelick FS: Etiopathogenesis of acute pancreatitis. Surg Clin North Am. 1999 Aug. PMID: 10470320

Gorelick FS, Otani T: Mechanisms of intracellular zymogen activation. Baillieres Best Pract Res Clin Gastroenterol. 1999 Jul. PMID: 11030603

Matovcik LM, Maranto AR, Soroka CJ, Gorelick FS, Smith J, Goldenring JR: Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells. J Histochem Cytochem. 1996 Nov. PMID: 8918899

Fallon MB, Gorelick FS, Anderson JM, Mennone A, Saluja A, Steer ML: Effect of cerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas. Gastroenterology. 1995 Jun. PMID: 7539388

Matovcik LM, Karapetian O, Czernik AJ, Marino CR, Kinder BK, Gorelick FS: Antibodies to an epitope on synapsin I detect a protein associated with the endocytic compartment in non-neuronal cells. Eur J Cell Biol. 1994 Dec. PMID: 7536673

Cui ZJ, Gorelick FS, Dannies PS: Calcium/calmodulin-dependent protein kinase-II activation in rat pituitary cells in the presence of thyrotropin-releasing hormone and dopamine. Endocrinology. 1994 May. PMID: 8156928

Chakraborty M, Chatterjee D, Gorelick FS, Baron R: Cell cycle-dependent and kinase-specific regulation of the apical Na/H exchanger and the Na,K-ATPase in the kidney cell line LLC-PK1 by calcitonin. Proc Natl Acad Sci U S A. 1994 Mar 15. PMID: 8134357

Marino CR, Leach SD, Schaefer JF, Miller LJ, Gorelick FS: Characterization of cAMP-dependent protein kinase activation by CCK in rat pancreas. FEBS Lett. 1993 Jan 18. PMID: 7678554

Marino CR, Gorelick FS: Scientific advances in cystic fibrosis. Gastroenterology. 1992 Aug. PMID: 1378805

Leach SD, Gorelick FS, Modlin IM: New perspectives on acute pancreatitis. Scand J Gastroenterol Suppl. 1992. PMID: 1439566

Marino CR, Castle JD, Gorelick FS: Regulated phosphorylation of secretory granule membrane proteins of the rat parotid gland. Am J Physiol. 1990 Jul. PMID: 1695488

Leach SD, Gorelick FS, Modlin IM: Acute pancreatitis at its centenary. The contribution of Reginald Fitz. Ann Surg. 1990 Jul. PMID: 2194439

Jamieson JD, Gorelick FS, Chang A: Development of secretagogue responsiveness in the pancreas. Scand J Gastroenterol Suppl. 1988. PMID: 2852401

Gorelick FS, Chang A, Jamieson JD: Calcium-calmodulin-stimulated protein kinase in developing pancreas. Am J Physiol. 1987 Oct. PMID: 3116856

Gorelick FS: Second messenger systems and adaptation. Gut. 1987. PMID: 2826313

Mateus Tavares Guerra, PhD

Kruglov E, Ananthanarayanan M, Sousa P, Weerachayaphorn J, Guerra MT, Nathanson MH: Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP. Biochem Biophys Res Commun. 2017 May 6; 2017 Mar 19. PMID: 28327356

Guerra MT: Mitochondrial MIsCUes in liver regeneration. Hepatology. 2016 Nov; 2016 Sep 30. PMID: 27629287

Guerra MT, Nathanson MH: Calcium signaling and secretion in cholangiocytes. Pancreatology. 2015 Jul; 2015 Jun 12. PMID: 26100660

Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH: Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506. J Biol Chem. 2015 Jan 2; 2014 Nov 5. PMID: 25378392

Kruglov EA, Gautam S, Guerra MT, Nathanson MH: Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes. Hepatology. 2011 Nov; 2011 Aug 30. PMID: 21748767

Cruz LN, Guerra MT, Kruglov E, Mennone A, Garcia CR, Chen J, Nathanson MH: Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. Hepatology. 2010 Jul. PMID: 20578149

Nagata J, Guerra MT, Shugrue CA, Gomes DA, Nagata N, Nathanson MH: Lipid rafts establish calcium waves in hepatocytes. Gastroenterology. 2007 Jul; 2007 Apr 11. PMID: 17631147

Hernandez E, Leite MF, Guerra MT, Kruglov EA, Bruna-Romero O, Rodrigues MA, Gomes DA, Giordano FJ, Dranoff JA, Nathanson MH: The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves. J Biol Chem. 2007 Mar 30; 2007 Feb 6. PMID: 17284437

Marius P, Guerra MT, Nathanson MH, Ehrlich BE, Leite MF: Calcium release from ryanodine receptors in the nucleoplasmic reticulum. Cell Calcium. 2006 Jan; 2005 Nov 9. PMID: 16289270

Sehgal S, Guerra MT, Kruglov EA, Wang J, Nathanson MH: Protein 4.1N does not interact with the inositol 1,4,5-trisphosphate receptor in an epithelial cell line. Cell Calcium. 2005 Nov. PMID: 16122796

Correa PR, Guerra MT, Leite MF, Spray DC, Nathanson MH: Endotoxin unmasks the role of gap junctions in the liver. Biochem Biophys Res Commun. 2004 Sep 24. PMID: 15336523

Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH: Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol. 2003 May. PMID: 12717445

Matija Hedl, PhD

Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. Nat Commun. 2017 Jun 28; 2017 Jun 28. PMID: 28656966

Lahiri A, Hedl M, Yan J, Abraham C: Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes. Nat Commun. 2017 Jun 8; 2017 Jun 8. PMID: 28593945

Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR: ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 Feb 23; 2017 Feb 23. PMID: 28230865

Hedl M, Abraham C: NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 2013 Jan 3. PMID: 23287275

Hedl M, Abraham C: Negative regulation of human mononuclear phagocyte function. Mucosal Immunol. 2013 Mar; 2013 Jan 23. PMID: 23340822

Hedl M, Abraham C: Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines. Gastroenterology. 2012 Dec; 2012 Sep 8. PMID: 22967725

Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W Jr, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA: IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 8; 2012 Oct 17. PMID: 23075849

Hedl M, Abraham C: IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells. J Immunol. 2012 Jun 1; 2012 Apr 27. PMID: 22544929

Avlin Barlow Imaeda, MD, PhD

Jangouk P, Chang JJ, Imaeda AB: Unsuspected Colonic Hemorrhage Found on Screening Colonoscopy. Gastroenterology. 2017 May; 2017 Apr 4. PMID: 28384453

Jirapinyo P, Abidi WM, Aihara H, Zaki T, Tsay C, Imaeda AB, Thompson CC: Preclinical endoscopic training using a part-task simulator: learning curve assessment and determination of threshold score for advancement to clinical endoscopy. Surg Endosc. 2017 Feb 22; 2017 Feb 22. PMID: 28229238

Plotkin E, Imaeda A: Small Intestinal Angioectasias Are Not Randomly Distributed in the Small Bowel and Most May Be Reached by Push Enteroscopy. J Clin Gastroenterol. 2016 Aug. PMID: 26485105

Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L: Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology. 2016 Feb; 2015 Oct 9. PMID: 26439436

Jirapinyo P, Imaeda AB, Thompson CC: Endoscopic training in gastroenterology fellowship: adherence to core curriculum guidelines. Surg Endosc. 2015 Dec; 2015 Mar 24. PMID: 25801105

Imaeda A: Confocal laser endomicroscopy for the detection of atrophic gastritis: a new application for confocal endomicroscopy? J Clin Gastroenterol. 2015 May-Jun. PMID: 25811115

Mehal W, Imaeda A: Cell death and fibrogenesis. Semin Liver Dis. 2010 Aug; 2010 Jul 21. PMID: 20665375

Imaeda A, Bender D, Fraenkel L: What is most important to patients when deciding about colorectal screening? J Gen Intern Med. 2010 Jul; 2010 Mar 23. PMID: 20309740

Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ: Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest. 2009 Feb; 2009 Jan 26. PMID: 19164858

Yasuko Iwakiri, PhD

Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed FEZ, Davies N, Sharma V, Iwakiri Y, Jalan R: Corrigendum to "Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension" [J Hepatol 62 (2015) 325-331]. J Hepatol. 2017 Sep 8; 2017 Sep 8. PMID: 28893453

Park JK, Iwakiri Y: Reply to the Letter to the Editor (HEP-17-1029) in regards to the paper on "An Endoplasmic Reticulum Protein, Nogo-B, Facilitates Alcoholic Liver Disease Through Regulation of Kupffer Cell Polarization". Hepatology. 2017 Jul 26; 2017 Jul 26. PMID: 28745830

Iwakiri Y: Reply. Hepatology. 2017 Jun; 2017 Apr 28. PMID: 28195342

Iwakiri Y, Nathanson MH: Alcohol and calcium make a potent cocktail. J Physiol. 2017 May 15; 2017 Apr 18. PMID: 28295353

Park JK, Shao M, Kim MY, Baik SK, Cho MY, Utsumi T, Satoh A, Ouyang X, Chung C, Iwakiri Y: An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization. Hepatology. 2017 May; 2017 Mar 22. PMID: 28090670

Tanaka M, Iwakiri Y: The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2016 Sep 14. PMID: 28105461

Iwakiri Y: The lymphatic system: A new frontier in hepatology. Hepatology. 2016 Sep; 2016 Jun 23. PMID: 27228259

Park JK, Utsumi T, Seo YE, Deng Y, Satoh A, Saltzman WM, Iwakiri Y: Cellular distribution of injected PLGA-nanoparticles in the liver. Nanomedicine. 2016 Jul; 2016 Mar 4. PMID: 26961463

Iwakiri Y: Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase. Clin Mol Hepatol. 2015 Dec; 2015 Dec 24. PMID: 26770919

Protiva P, Gong J, Sreekumar B, Torres R, Zhang X, Belinsky GS, Cornwell M, Crawford SE, Iwakiri Y, Chung C: Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver. Cell Mol Gastroenterol Hepatol. 2015 Sep 1; 2015 Jul 4. PMID: 26473164

Wang S, Song K, Srivastava R, Dong C, Go GW, Li N, Iwakiri Y, Mani A: Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a. FASEB J. 2015 Aug; 2015 Apr 27. PMID: 25917329

Iwakiri Y, Kim MY: Nitric oxide in liver diseases. Trends Pharmacol Sci. 2015 Aug; 2015 May 28. PMID: 26027855

Kim MY, Iwakiri Y: Can hypersplenism secondary to portal hypertension be treated by non-selective beta blockers? Hepatol Int. 2015 Jul; 2015 Jan 25. PMID: 25788189

Kurobe H, Maxfield MW, Tara S, Rocco KA, Bagi PS, Yi T, Udelsman B, Zhuang ZW, Cleary M, Iwakiri Y, Breuer CK, Shinoka T: Development of small diameter nanofiber tissue engineered arterial grafts. PLoS One. 2015; 2015 Apr 1. PMID: 25830942

Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed Fel Z, Davies N, Sharma V, Iwakiri Y, Jalan R: Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension. J Hepatol. 2015 Feb; 2014 Aug 23. PMID: 25152204

Iwakiri Y, Shah V, Rockey DC: Vascular pathobiology in chronic liver disease and cirrhosis - current status and future directions. J Hepatol. 2014 Oct; 2014 Jun 6. PMID: 24911462

Iwakiri Y: Pathophysiology of portal hypertension. Clin Liver Dis. 2014 May; 2014 Feb 25. PMID: 24679494

Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C: Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology. 2014 Apr; 2014 Jan 23. PMID: 24456163

Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC: eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases. J Cell Sci. 2013 Dec 15; 2013 Sep 17. PMID: 24046447

Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, Chung C: Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content. FASEB J. 2013 Nov; 2013 Jul 25. PMID: 23887690

Chung C, Iwakiri Y: The lymphatic vascular system in liver diseases: its role in ascites formation. Clin Mol Hepatol. 2013 Jun; 2013 Jun 27. PMID: 23837133

Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y: Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice. Hepatology. 2013 May; 2013 Mar 19. PMID: 23299899

Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y: Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice. Am J Pathol. 2013 Mar; 2013 Jan 9. PMID: 23313137

Chung C, Iwakiri Y: Activated hepatic stellate cells: negative regulators of hepatocyte proliferation in liver diseases. Hepatology. 2012 Jul. PMID: 22876366

Huang HC, Haq O, Utsumi T, Sethasine S, Abraldes JG, Groszmann RJ, Iwakiri Y: Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure. J Cell Mol Med. 2012 May. PMID: 21801303

Iwakiri Y: A role of miR-33 for cell cycle progression and cell proliferation. Cell Cycle. 2012 Mar 15; 2012 Mar 15. PMID: 22395363

Iwakiri Y: Endothelial dysfunction in the regulation of cirrhosis and portal hypertension. Liver Int. 2012 Feb; 2011 Jul 5. PMID: 21745318

Sangwung P, Greco TM, Wang Y, Ischiropoulos H, Sessa WC, Iwakiri Y: Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. PLoS One. 2012; 2012 Feb 21. PMID: 22363674

Iwakiri Y: S-nitrosylation of proteins: a new insight into endothelial cell function regulated by eNOS-derived NO. Nitric Oxide. 2011 Aug 1; 2011 Apr 30. PMID: 21554971

Zhang D, Utsumi T, Huang HC, Gao L, Sangwung P, Chung C, Shibao K, Okamoto K, Yamaguchi K, Groszmann RJ, Jozsef L, Hao Z, Sessa WC, Iwakiri Y: Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis. Hepatology. 2011 Apr. PMID: 21480333

Iwakiri Y, Grisham M, Shah V: Vascular biology and pathobiology of the liver: Report of a single-topic symposium. Hepatology. 2008 May. PMID: 18393322

Fernández-Hernando C, Ackah E, Yu J, Suárez Y, Murata T, Iwakiri Y, Prendergast J, Miao RQ, Birnbaum MJ, Sessa WC: Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab. 2007 Dec. PMID: 18054314

Iwakiri Y: The molecules: mechanisms of arterial vasodilatation observed in the splanchnic and systemic circulation in portal hypertension. J Clin Gastroenterol. 2007 Nov-Dec. PMID: 17975478

Iwakiri Y, Satoh A, Chatterjee S, Toomre DK, Chalouni CM, Fulton D, Groszmann RJ, Shah VH, Sessa WC: Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking. Proc Natl Acad Sci U S A. 2006 Dec 26; 2006 Dec 14. PMID: 17170139

Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC: Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest. 2005 Aug. PMID: 16075056

Fulton D, Babbitt R, Zoellner S, Fontana J, Acevedo L, McCabe TJ, Iwakiri Y, Sessa WC: Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. J Biol Chem. 2004 Jul 16; 2004 May 10. PMID: 15136572

Gratton JP, Lin MI, Yu J, Weiss ED, Jiang ZL, Fairchild TA, Iwakiri Y, Groszmann R, Claffey KP, Cheng YC, Sessa WC: Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell. 2003 Jul. PMID: 12892711

Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ: Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. Am J Physiol Gastrointest Liver Physiol. 2002 Nov. PMID: 12381520

Iwakiri Y, Tsai MH, McCabe TJ, Gratton JP, Fulton D, Groszmann RJ, Sessa WC: Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension. Am J Physiol Heart Circ Physiol. 2002 Jun. PMID: 12003815

Priya Arvind Jamidar, FACG, FASGE, MBChB

Muniraj T, Jamidar PA, Nealon WH, Aslanian HR: Endoscopic Management of Pancreatic Fluid Collections. J Clin Gastroenterol. 2017 Jan. PMID: 27548730

Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR: Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP? Dig Dis Sci. 2016 Mar; 2015 Nov 14. PMID: 26572779

Yaghoobi M, Pauls Q, Durkalski V, Romagnuolo J, Fogel EL, Tarnasky PR, Aliperti G, Freeman ML, Kozarek RA, Jamidar PA, Wilcox CM, Elta GH, Hawes RH, Wood-Williams A, Cotton PB: Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy: results from the EPISOD prospective multicenter randomized sham-controlled study. Endoscopy. 2015 Oct; 2015 Jul 10. PMID: 26165739

Aslanian HR, Ahmed AM, Jamidar PA: Is Advanced Endoscopy Training Worth it? Clin Gastroenterol Hepatol. 2015 Jul. PMID: 26091939

Muniraj T, Aslanian HR, Laine L, Farrell J, Ciarleglio MM, Deng Y, Ho H, Jamidar PA: A double-blind, randomized, sham-controlled trial of the effect of a radiation-attenuating drape on radiation exposure to endoscopy staff during ERCP. Am J Gastroenterol. 2015 May; 2015 Mar 31. PMID: 25823765

Rustagi T, Jamidar PA: Endoscopic treatment of malignant biliary strictures. Curr Gastroenterol Rep. 2015 Jan. PMID: 25613178

Rustagi T, Jamidar PA: Endoscopic management of benign biliary strictures. Curr Gastroenterol Rep. 2015 Jan. PMID: 25613176

Rustagi T, Jamidar PA: Endoscopic retrograde cholangiopancreatography (ERCP)-related adverse events: post-ERCP pancreatitis. Gastrointest Endosc Clin N Am. 2015 Jan. PMID: 25442962

Rustagi T, Jamidar PA: Endoscopic retrograde cholangiopancreatography-related adverse events: general overview. Gastrointest Endosc Clin N Am. 2015 Jan. PMID: 25442961

Rustagi T, Jamidar PA: Intraductal radiofrequency ablation for management of malignant biliary obstruction. Dig Dis Sci. 2014 Nov; 2014 Jun 7. PMID: 24906696

Rustagi T, Jamidar PA: Single-port pancreatectomy: ready for prime time. J Clin Gastroenterol. 2014 Jul. PMID: 24781386

Romagnuolo J, Cotton PB, Durkalski V, Pauls Q, Brawman-Mintzer O, Drossman DA, Mauldin P, Orrell K, Williams AW, Fogel EL, Tarnasky PR, Aliperti G, Freeman ML, Kozarek RA, Jamidar PA, Wilcox CM, Serrano J, Elta GH: Can patient and pain characteristics predict manometric sphincter of Oddi dysfunction in patients with clinically suspected sphincter of Oddi dysfunction? Gastrointest Endosc. 2014 May; 2014 Jan 25. PMID: 24472759

Bari K, Aslanian HR, Pollak J, Reiner E, Salem RR, Taddei TH, Emre SH, Jamidar PA: Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography. ACG Case Rep J. 2013 Oct; 2013 Oct 8. PMID: 26157820

Aslanian HR, Shieh FK, Chan FW, Ciarleglio MM, Deng Y, Rogart JN, Jamidar PA, Siddiqui UD: Nurse observation during colonoscopy increases polyp detection: a randomized prospective study. Am J Gastroenterol. 2013 Feb. PMID: 23381064

Shieh FK, Drumm H, Nathanson MH, Jamidar PA: High-definition confocal endomicroscopy of the common bile duct. J Clin Gastroenterol. 2012 May-Jun. PMID: 22011583

Aslanian HR, Estrada JD, Rossi F, Dziura J, Jamidar PA, Siddiqui UD: Endoscopic ultrasound and endoscopic retrograde cholangiopancreatography for obstructing pancreas head masses: combined or separate procedures? J Clin Gastroenterol. 2011 Sep. PMID: 21301359

Rogart JN, Siddiqui UD, Jamidar PA, Aslanian HR: Fellow involvement may increase adenoma detection rates during colonoscopy. Am J Gastroenterol. 2008 Nov; 2008 Aug 27. PMID: 18759826

Roberts KE, Panait L, Duffy AJ, Jamidar PA, Bell RL: Laparoscopic-assisted transgastric endoscopy: current indications and future implications. JSLS. 2008 Jan-Mar. PMID: 18402736

Loren Laine, MD

Kim SJ, Ohanian E, Lee F, Nam B, Che K, Laine L, Kim SE, Kim JJ: Predictors and outcomes of delayed plastic biliary stent removal following endoscopic retrograde cholangiopancreatography. Scand J Gastroenterol. 2017 Oct; 2017 Jun 28. PMID: 28657377

Singh M, Sacatos M, Laine L: Impact of Changeover to Newer Endoscopic Systems on Quality and Efficiency of Screening and Surveillance Colonoscopy: Equipment or Endoscopist. J Clin Gastroenterol. 2017 Sep 12; 2017 Sep 12. PMID: 28906425

He H, Tan C, Wu J, Dai N, Hu W, Zhang Y, Laine L, Scheiman J, Kim JJ: Accuracy of ASGE high-risk criteria in evaluation of patients with suspected common bile duct stones. Gastrointest Endosc. 2017 Sep; 2017 Feb 4. PMID: 28174126

Buxbaum J, Sahakian A, Ko C, Jayaram P, Lane C, Yu CY, Kankotia R, Laine L: Randomized trial of cholangioscopy-guided laser lithotripsy versus conventional therapy for large bile duct stones (with videos). Gastrointest Endosc. 2017 Aug 30; 2017 Aug 30. PMID: 28866457

Lu Y, Jones DJ, Sharara N, Kaltenbach T, Laine L, McQuaid K, Soetikno R, Subramanian V, Barkun A: Transparency ethics in practice: Revisiting financial conflicts of interest disclosure forms in clinical practice guidelines. PLoS One. 2017; 2017 Aug 25. PMID: 28841650

Kaltenbach TR, Soetikno RM, DeVivo R, Laine LA, Barkun A, McQuaid KR, Optimizing Quality of Endoscopy in IBD Group.: Optimizing quality of endoscopy in inflammatory bowel disease: focus on surveillance and management of colorectal dysplasia using interactive image and video-based teaching. Gastrointest Endosc. 2017 Aug 14; 2017 Aug 14. PMID: 28818507

Laine L: Is there a role for combined sclerotherapy and ligation in the endoscopic treatment of gastroesophageal varices? Gastrointest Endosc. 2017 Aug. PMID: 28728669

Laine L: Bleeding With Direct Oral Anticoagulants: The Gastrointestinal Tract and Beyond. Clin Gastroenterol Hepatol. 2017 Jun 27; 2017 Jun 27. PMID: 28666949

Gupta N, Brill JV, Canto M, DeMarco D, Fennerty BM, Laine L, Lieberman D, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Tokar JL, Kochman ML: AGA White Paper: Training and Implementation of Endoscopic Image Enhancement Technologies. Clin Gastroenterol Hepatol. 2017 Jun. PMID: 28528939

Buxbaum JL, Quezada M, Da B, Jani N, Lane C, Mwengela D, Kelly T, Jhun P, Dhanireddy K, Laine L: Early Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis. Am J Gastroenterol. 2017 May; 2017 Mar 7. PMID: 28266591

Laine L, Laursen SB, Dalton HR, Ngu JH, Schultz M, Stanley AJ: Relationship of time to presentation after onset of upper GI bleeding with patient characteristics and outcomes: a prospective study. Gastrointest Endosc. 2017 Apr 7; 2017 Apr 7. PMID: 28396275

Sheibani S, Laine L: Reply. Hepatology. 2017 Apr; 2016 Nov 29. PMID: 27783417

Njei B, McCarty TR, Laine L: Early transjugular intrahepatic portosystemic shunt in US patients hospitalized with acute esophageal variceal bleeding. J Gastroenterol Hepatol. 2017 Apr. PMID: 27624167

Buxbaum JL, Hormozdi D, Dinis-Ribeiro M, Lane C, Dias-Silva D, Sahakian A, Jayaram P, Pimentel-Nunes P, Shue D, Pepper M, Cho D, Laine L: Narrow-band imaging versus white light versus mapping biopsy for gastric intestinal metaplasia: a prospective blinded trial. Gastrointest Endosc. 2017 Mar 30; 2017 Mar 30. PMID: 28366441

Kelly CR, Kim AM, Laine L, Wu GD: The AGA's Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics. Gastroenterology. 2017 Mar; 2017 Jan 29. PMID: 28143773

Sachar H, Pichetshote N, Nandigam K, Vaidya K, Laine L: Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. Gastrointest Endosc. 2017 Jan 31; 2017 Jan 31. PMID: 28159539

Stanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R, Zakko L, Thornton S, Wilkinson K, Khor CJ, Murray IA, Laursen SB, International Gastrointestinal Bleeding Consortium.: Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study. BMJ. 2017 Jan 4; 2017 Jan 4. PMID: 28053181

Zakko L, Rustagi T, Douglas M, Laine L: No Benefit From Platelet Transfusion for Gastrointestinal Bleeding in Patients Taking Antiplatelet Agents. Clin Gastroenterol Hepatol. 2017 Jan; 2016 Jul 25. PMID: 27464591

Park S, Abdi T, Gentry M, Laine L: Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis. Am J Gastroenterol. 2016 Dec; 2016 Oct 11. PMID: 27725645

Buxbaum J, Leonor P, Tung J, Lane C, Sahakian A, Laine L: Randomized Trial of Endoscopist-Controlled vs. Assistant-Controlled Wire-Guided Cannulation of the Bile Duct. Am J Gastroenterol. 2016 Dec; 2016 Jul 5. PMID: 27377519

Laine L: Risk Assessment Tools for Gastrointestinal Bleeding. Clin Gastroenterol Hepatol. 2016 Nov; 2016 Aug 10. PMID: 27521511

Laine L: Upper Gastrointestinal Bleeding Due to a Peptic Ulcer. N Engl J Med. 2016 Sep 22. PMID: 27653581

Vaduganathan M, Cannon CP, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Bhatt DL, COGENT Investigators.: Efficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial. Am J Med. 2016 Sep; 2016 Apr 30. PMID: 27143321

Popov VB, Thompson CC, Kumar N, Ciarleglio MM, Deng Y, Laine L: Effect of Intragastric Balloons on Liver Enzymes: A Systematic Review and Meta-Analysis. Dig Dis Sci. 2016 Sep; 2016 May 20. PMID: 27207181

Clark BT, Laine L: High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps. Clin Gastroenterol Hepatol. 2016 Aug; 2016 Apr 7. PMID: 27060426

Park S, Laine L: Pursuing a Clinical Academic Career During Gastroenterology Fellowship. Dig Dis Sci. 2016 Aug. PMID: 27193565

Parikh ND, Chaptini L, Njei B, Laine L: Diagnosis of sessile serrated adenomas/polyps with image-enhanced endoscopy: a systematic review and meta-analysis. Endoscopy. 2016 Aug; 2016 May 25. PMID: 27223636

Sheibani S, Khemichian S, Kim JJ, Hou L, Yan AW, Buxbaum J, Dara L, Laine L: Randomized trial of 1-week versus 2-week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding. Hepatology. 2016 Aug; 2016 May 17. PMID: 27082942

Laine L, Nagar A: Long-Term PPI Use: Balancing Potential Harms and Documented Benefits. Am J Gastroenterol. 2016 Jul; 2016 Apr 26. PMID: 27113114

Graham DY, Laine L: The Toronto Helicobacter pylori Consensus in Context. Gastroenterology. 2016 Jul; 2016 May 20. PMID: 27215659

Clark BT, Parikh ND, Laine L: Yield of repeat forward-view examination of the right side of the colon in screening and surveillance colonoscopy. Gastrointest Endosc. 2016 Jul; 2016 Jan 6. PMID: 26769408

Laine L: CLINICAL PRACTICE. Upper Gastrointestinal Bleeding Due to a Peptic Ulcer. N Engl J Med. 2016 Jun 16. PMID: 27305194

Laine L: Deflating balloon tamponade: Should we expand the use of stents for severe refractory esophageal variceal bleeding? Hepatology. 2016 Jun; 2016 Mar 9. PMID: 27205898

Langberg KM, Parikh ND, Deng Y, Ciarlegio M, Laine L, Aslanian HR: Digital chromoendoscopy utilization in clinical practice: A survey of gastroenterologists in Connecticut. World J Gastrointest Pharmacol Ther. 2016 May 6. PMID: 27158543

Kaltenbach T, McQuaid KR, Soetikno R, Laine L: Improving detection of colorectal dysplasia in inflammatory bowel disease surveillance. Gastrointest Endosc. 2016 May. PMID: 27102531

Vaduganathan M, Bhatt DL, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Cannon CP, COGENT Investigators.: Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. J Am Coll Cardiol. 2016 Apr 12; 2016 Mar 21. PMID: 27012778

Soetikno R, Kaltenbach T, McQuaid KR, Subramanian V, Kumar R, Barkun AN, Laine L: Paradigm Shift in the Surveillance and Management of Dysplasia in Inflammatory Bowel Disease (West). Dig Endosc. 2016 Apr. PMID: 26866420

Sahakian AB, Laine L, Jamidar PA, Siddiqui UD, Duffy A, Ciarleglio MM, Deng Y, Nagar A, Aslanian HR: Can a Computerized Simulator Assess Skill Level and Improvement in Performance of ERCP? Dig Dis Sci. 2016 Mar; 2015 Nov 14. PMID: 26572779

Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L: Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology. 2016 Feb; 2015 Oct 9. PMID: 26439436

Sanduleanu S, Kaltenbach T, Barkun A, McCabe RP, Velayos F, Picco MF, Laine L, Soetikno R, McQuaid KR: A roadmap to the implementation of chromoendoscopy in inflammatory bowel disease colonoscopy surveillance practice. Gastrointest Endosc. 2016 Jan; 2015 Sep 11. PMID: 26364967

Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R: Response to Editorial of Peter D.R. Higgins (July 2015). Am J Gastroenterol. 2015 Dec. PMID: 26673505

Sharma P, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lieberman D, Lightdale C, Montgomery E, Odze R, Tokar J, Kochman M: White Paper AGA: Advanced Imaging in Barrett's Esophagus. Clin Gastroenterol Hepatol. 2015 Dec; 2015 Oct 14. PMID: 26462567

Lieberman D, Brill J, Canto M, DeMarco D, Fennerty B, Gupta N, Laine L, Lightdale C, Montgomery E, Odze R, Rex D, Sharma P, Kochman M, Tokar J: Management of Diminutive Colon Polyps Based on Endoluminal Imaging. Clin Gastroenterol Hepatol. 2015 Nov; 2015 Jul 17. PMID: 26192139

Rustagi T, Aslanian HR, Laine L: Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review. J Clin Gastroenterol. 2015 Nov-Dec. PMID: 25626632

Kim JJ, Lee F, Laine L: Letter: acute cholangitis: understanding predictors of outcome--authors' reply. Aliment Pharmacol Ther. 2015 Sep. PMID: 26278564

Vardi M, Cryer BL, Cohen M, Lanas A, Schnitzer TJ, Lapuerta P, Goldsmith MA, Laine L, Doros G, Liu Y, McIntosh AI, Cannon CP, Bhatt DL: The effects of proton pump inhibition on patient-reported severity of dyspepsia when receiving dual anti-platelet therapy with clopidogrel and low-dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial. Aliment Pharmacol Ther. 2015 Aug; 2015 May 29. PMID: 26032114

Lee F, Ohanian E, Rheem J, Laine L, Che K, Kim JJ: Delayed endoscopic retrograde cholangiopancreatography is associated with persistent organ failure in hospitalised patients with acute cholangitis. Aliment Pharmacol Ther. 2015 Jul; 2015 May 22. PMID: 25997554

Kelly CR, Kahn S, Kashyap P, Laine L, Rubin D, Atreja A, Moore T, Wu G: Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook. Gastroenterology. 2015 Jul; 2015 May 15. PMID: 25982290

Yan K, Bridges JF, Augustin S, Laine L, Garcia-Tsao G, Fraenkel L: Factors impacting physicians' decisions to prevent variceal hemorrhage. BMC Gastroenterol. 2015 May 2; 2015 May 2. PMID: 25934271

Muniraj T, Aslanian HR, Laine L, Farrell J, Ciarleglio MM, Deng Y, Ho H, Jamidar PA: A double-blind, randomized, sham-controlled trial of the effect of a radiation-attenuating drape on radiation exposure to endoscopy staff during ERCP. Am J Gastroenterol. 2015 May; 2015 Mar 31. PMID: 25823765

Chaptini L, Laine L: Can I improve my adenoma detection rate? J Clin Gastroenterol. 2015 Apr. PMID: 25647725

Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, SCENIC Guideline Development Panel.: SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastroenterology. 2015 Mar. PMID: 25702852

Laine L, Kaltenbach T, Barkun A, McQuaid KR, Subramanian V, Soetikno R, SCENIC Guideline Development Panel.: SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastrointest Endosc. 2015 Mar. PMID: 25708752

Solad Y, Wang C, Laine L, Deng Y, Schwartz H, Ciarleglio MM, Aslanian HR: Influence of colonoscopy quality measures on patients' colonoscopist selection. Am J Gastroenterol. 2015 Feb; 2014 Jul 29. PMID: 25070055

Clark BT, Rustagi T, Laine L: What level of bowel prep quality requires early repeat colonoscopy: systematic review and meta-analysis of the impact of preparation quality on adenoma detection rate. Am J Gastroenterol. 2014 Nov; 2014 Aug 19. PMID: 25135006

Sachar H, Vaidya K, Laine L: Intermittent vs continuous proton pump inhibitor therapy for high-risk bleeding ulcers: a systematic review and meta-analysis. JAMA Intern Med. 2014 Nov. PMID: 25201154

Laine L: NSAID-associated gastrointestinal bleeding: assessing the role of concomitant medications. Gastroenterology. 2014 Oct; 2014 Sep 11. PMID: 25167988

Chaptini L, Chaaya A, Depalma F, Hunter K, Peikin S, Laine L: Variation in polyp size estimation among endoscopists and impact on surveillance intervals. Gastrointest Endosc. 2014 Oct; 2014 Mar 27. PMID: 24679658

Laine L, Ganz RA: Our new president--John I. Allen, MD, MBA, AGAF. Gastroenterology. 2014 May; 2014 Mar 28. PMID: 24680804

Hecht GA, Blaser MJ, Gordon J, Kaplan LM, Knight R, Laine L, Peek R, Sanders ME, Sartor B, Wu GD, Yang VW: What is the value of a food and drug administration investigational new drug application for fecal microbiota transplantation to treat Clostridium difficile Infection? Clin Gastroenterol Hepatol. 2014 Feb; 2013 Oct 20. PMID: 24148361

Buxbaum J, Yan A, Yeh K, Lane C, Nguyen N, Laine L: Aggressive hydration with lactated Ringer's solution reduces pancreatitis after endoscopic retrograde cholangiopancreatography. Clin Gastroenterol Hepatol. 2014 Feb; 2013 Aug 3. PMID: 23920031

Kim JJ, Sheibani S, Park S, Buxbaum J, Laine L: Causes of bleeding and outcomes in patients hospitalized with upper gastrointestinal bleeding. J Clin Gastroenterol. 2014 Feb. PMID: 23685847

Kim JJ, Han A, Yan AW, Cao D, Laine L: Gastroenterologists' practice patterns for positive fecal occult blood test. J Clin Gastroenterol. 2014 Feb. PMID: 23632353

Sahakian AB, Aslanian HR, Mehra M, Rossi F, Laine L, Sanchez M, Ciarleglio MM, Adimoolam V, Siddiqui UD: The utility of esophagogastroduodenoscopy before endoscopic ultrasonography in patients undergoing endoscopic ultrasonography for pancreatico-biliary and mediastinal indications. J Clin Gastroenterol. 2013 Nov-Dec. PMID: 23632349

Laine L, Yang H, Chang SC, Datto C: Trends for incidence of hospitalization and death due to GI complications in the United States from 2001 to 2009. Am J Gastroenterol. 2012 Aug; 2012 Jun 12. PMID: 22688850

Laine L, Jensen DM: Management of patients with ulcer bleeding. Am J Gastroenterol. 2012 Mar; 2012 Feb 7. PMID: 22310222

Annmarie Huysman Liapakis, MD

Levitsky J, Formica RN, Bloom RD, Charlton M, Curry M, Friedewald J, Friedman J, Goldberg D, Hall S, Ison M, Kaiser T, Klassen D, Klintmalm G, Kobashigawa J, Liapakis A, O'Conner K, Reese P, Stewart D, Terrault N, Theodoropoulos N, Trotter J, Verna E, Volk M: The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation. Am J Transplant. 2017 May 29; 2017 May 29. PMID: 28556422

Bakhit M, McCarty TR, Park S, Njei B, Cho M, Karagozian R, Liapakis A: Vanishing bile duct syndrome in Hodgkin's lymphoma: A case report and literature review. World J Gastroenterol. 2017 Jan 14. PMID: 28127210

Bakhit M, McCarty TR, Park S, Njei B, Cho M, Karagozian R, Liapakis A: Vanishing Bile Duct Syndrome in Hodgkin's Lymphoma: A Single Center Experience and Clinical Pearls. J Clin Gastroenterol. 2016 Sep. PMID: 27203429

Saxena V, Koraishy FM, Sise ME, Lim JK, Schmidt M, Chung RT, Liapakis A, Nelson DR, Fried MW, Terrault NA, HCV-TARGET.: Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function. Liver Int. 2016 Jun; 2016 Mar 24. PMID: 26923436

Waldman AH, McNiff JM, Liapakis A, Asch WS, Smith-Marrone S, Colegio OR: Revision of immunosuppression in a solid organ transplant recipient leads to complete remission of metastatic undifferentiated carcinoma. JAAD Case Rep. 2015 Nov; 2015 Nov 24. PMID: 27051810

Roth D, Nelson DR, Bruchfeld A, Liapakis A, Silva M, Monsour H Jr, Martin P, Pol S, Londoño MC, Hassanein T, Zamor PJ, Zuckerman E, Wan S, Jackson B, Nguyen BY, Robertson M, Barr E, Wahl J, Greaves W: Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 study. Lancet. 2015 Oct 17; 2015 Oct 5. PMID: 26456905

Merola J, Liapakis A, Mulligan DC, Yoo PS: Non-alcoholic fatty liver disease following liver transplantation: a clinical review. Clin Transplant. 2015 Sep; 2015 Aug 11. PMID: 26147308

Do A, Mittal Y, Liapakis A, Cohen E, Chau H, Bertuccio C, Sapir D, Wright J, Eggers C, Drozd K, Ciarleglio M, Deng Y, Lim JK: Drug Authorization for Sofosbuvir/Ledipasvir (Harvoni) for Chronic HCV Infection in a Real-World Cohort: A New Barrier in the HCV Care Cascade. PLoS One. 2015; 2015 Aug 27. PMID: 26312999

Joseph K Lim, MD

Welzel TM, Nelson DR, Morelli G, Di Bisceglie A, Reddy RK, Kuo A, Lim JK, Darling J, Pockros P, Galati JS, Frazier LM, Alqahtani S, Sulkowski MS, Vainorius M, Akushevich L, Fried MW, Zeuzem S, HCV-TARGET Study Group.: Effectiveness and safety of sofosbuvir plus ribavirin for the treatment of HCV genotype 2 infection: results of the real-world, clinical practice HCV-TARGET study. Gut. 2017 Oct; 2016 Jul 13. PMID: 27418632

So-Armah KA, Lim JK, Lo Re V, Tate JP, Chang CH, Butt AA, Gibert CL, Rimland D, Marconi VC, Goetz MB, Rodriguez-Barradas MC, Budoff MJ, Tindle HA, Samet JH, Justice AC, Freiberg MS, Veterans Aging Cohort Study Project Team.: FIB-4 stage of liver fibrosis predicts incident heart failure among HIV-infected and uninfected patients. Hepatology. 2017 Oct; 2017 Aug 30. PMID: 28543215

Lo Re Rd V, Zeldow B, Kallan MJ, Tate JP, Carbonari DM, Hennessy S, Kostman JR, Lim JK, Goetz MB, Gross R, Justice AC, Roy JA: Risk of liver decompensation with cumulative use of mitochondrial toxic nucleoside analogues in HIV/hepatitis C virus coinfection. Pharmacoepidemiol Drug Saf. 2017 Jul 19; 2017 Jul 19. PMID: 28722244

Ooka K, Connolly JJ, Lim JK: Medicaid Reimbursement for Oral Direct Antiviral Agents for the Treatment of Chronic Hepatitis C. Am J Gastroenterol. 2017 Jun; 2017 Apr 4. PMID: 28374816

Evon DM, Golin CE, Stewart P, Fried MW, Alston S, Reeve B, Lok AS, Sterling RK, Lim JK, Reau N, Sarkar S, Nelson DR, Reddy KR, Di Bisceglie AM: Patient engagement and study design of PROP UP: A multi-site patient-centered prospective observational study of patients undergoing hepatitis C treatment. Contemp Clin Trials. 2017 Jun; 2017 Mar 22. PMID: 28342989

Lim JK, Flamm SL, Singh S, Falck-Ytter YT, Clinical Guidelines Committee of the American Gastroenterological Association.: American Gastroenterological Association Institute Guideline on the Role of Elastography in the Evaluation of Liver Fibrosis. Gastroenterology. 2017 May. PMID: 28442119

Jacobson IM, Lim JK, Fried MW: American Gastroenterological Association Institute Clinical Practice Update-Expert Review: Care of Patients Who Have Achieved a Sustained Virologic Response After Antiviral Therapy for Chronic Hepatitis C Infection. Gastroenterology. 2017 May; 2017 Mar 23. PMID: 28344022

McCarty TR, Lim JK: Developing therapies to treat hepatitis C infection in post-liver transplant recipients. Expert Opin Pharmacother. 2017 Feb; 2017 Jan 6. PMID: 28024124

Gowda C, Newcomb CW, Liu Q, Carbonari DM, Lewis JD, Forde KA, Goldberg DS, Reddy KR, Roy JA, Marks AR, Schneider JL, Kostman JR, Tate JP, Lim JK, Justice AC, Goetz MB, Corley DA, Lo Re V: Risk of Acute Liver Injury With Antiretroviral Therapy by Viral Hepatitis Status. Open Forum Infect Dis. 2017 Spring; 2017 Jan 28. PMID: 28470014

Kwo PY, Cohen SM, Lim JK: ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. Am J Gastroenterol. 2017 Jan; 2016 Dec 20. PMID: 27995906

Friedman LS, Inadomi JM, Kalloo AM, Katzka DA, Kim LS, Koch J, Lieberman D, Lichtenstein GR, Lim JK, Pandolfino JE, Shin AS, Siedler MR: Introduction of Clinical Practice Update Committee Articles. Clin Gastroenterol Hepatol. 2017 Jan. PMID: 27979048

Justice AC, Esserman D, Sarkar S, Levin FL, Skanderson M, Lim JK: Reply to: "Hepatitis C testing in U.S. veterans born 1945-1965: An update". J Hepatol. 2017 Jan; 2016 Oct 4. PMID: 27717863

Terrault NA, Zeuzem S, Di Bisceglie AM, Lim JK, Pockros PJ, Frazier LM, Kuo A, Lok AS, Shiffman ML, Ben Ari Z, Akushevich L, Vainorius M, Sulkowski MS, Fried MW, Nelson DR, HCV-TARGET Study Group.: Effectiveness of Ledipasvir-Sofosbuvir Combination in Patients With Hepatitis C Virus Infection and Factors Associated With Sustained Virologic Response. Gastroenterology. 2016 Dec; 2016 Aug 24. PMID: 27565882

Njei B, McCarty TR, Fortune BE, Lim JK: Optimal timing for hepatitis C therapy in US patients eligible for liver transplantation: a cost-effectiveness analysis. Aliment Pharmacol Ther. 2016 Nov; 2016 Sep 19. PMID: 27640785

Fortune BE, Garcia-Tsao G, Ciarleglio M, Deng Y, Fallon MB, Sigal S, Chalasani NP, Lim JK, Reuben A, Vargas HE, Abrams G, Lewis MD, Hassanein T, Trotter JF, Sanyal AJ, Beavers KL, Ganger D, Thuluvath PJ, Grace ND, Groszmann RJ, Vapreotide Study Group.: Child-Turcotte-Pugh Class is Best at Stratifying Risk in Variceal Hemorrhage: Analysis of a US Multicenter Prospective Study. J Clin Gastroenterol. 2016 Oct 24; 2016 Oct 24. PMID: 27779613

Wong CR, Nguyen MH, Lim JK: Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease. World J Gastroenterol. 2016 Oct 7. PMID: 27729736

Beckman AL, Bilinski A, Boyko R, Camp GM, Wall AT, Lim JK, Wang EA, Bruce RD, Gonsalves GS: New Hepatitis C Drugs Are Very Costly And Unavailable To Many State Prisoners. Health Aff (Millwood). 2016 Oct 1. PMID: 27702964

Njei B, McCarty TR, Luk J, Ewelukwa O, Ditah I, Lim JK: Use of transient elastography in patients with HIV-HCV coinfection: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2016 Oct. PMID: 26952020

Ooka K, Lim JK: Treatment of Hepatitis C in Patients Undergoing Immunosuppressive Drug Therapy. J Clin Transl Hepatol. 2016 Sep 28; 2016 Aug 10. PMID: 27777889

Ahn J, Lim JK, Lee HM, Lok AS, Nguyen M, Pan CQ, Mannalithara A, Te H, Reddy KR, Trinh H, Chu D, Tran T, Lau D, Leduc TS, Min A, Trong Le L, Bae H, Van Tran S, Do S, Hann HW, Wong C, Han S, Pillai A, Park JS, Tong M, Scaglione S, Woog J, Kim WR: Lower Observed Hepatocellular Carcinoma Incidence in Chronic Hepatitis B Patients Treated With Entecavir: Results of the ENUMERATE Study. Am J Gastroenterol. 2016 Sep; 2016 Jun 21. PMID: 27325221

Tetrault JM, Tate JP, Edelman EJ, Gordon AJ, Lo Re V 3rd, Lim JK, Rimland D, Goulet J, Crystal S, Gaither JR, Gibert CL, Rodriguez-Barradas MC, Fiellin LE, Bryant K, Justice AC, Fiellin DA: Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection. J Subst Abuse Treat. 2016 Sep; 2016 Jun 6. PMID: 27431048

Njei B, Do A, Lim JK: Prevalence of hepatitis delta infection in the United States: National Health and Nutrition Examination Survey, 1999-2012. Hepatology. 2016 Aug; 2015 Nov 23. PMID: 26453027

Sarkar S, Esserman DA, Skanderson M, Levin FL, Justice AC, Lim JK: Disparities in hepatitis C testing in U.S. veterans born 1945-1965. J Hepatol. 2016 Aug; 2016 Apr 27. PMID: 27130843

Katzka DA, Friedman LS, Inadomi JM, Kalloo AM, Kim LS, Koch J, Lieberman D, Lichtenstein GR, Lim JK, Pandolfino JE, Shin AS, Siedler MR: Introduction to Clinical Practice Update Committee Articles. Gastroenterology. 2016 Jul; 2016 May 27. PMID: 27240901

Lim JK: The Role of Bariatric Surgery in the Management of Nonalcoholic Steatohepatitis. Gastroenterol Hepatol (N Y). 2016 Jun. PMID: 27493600

Saxena V, Koraishy FM, Sise ME, Lim JK, Schmidt M, Chung RT, Liapakis A, Nelson DR, Fried MW, Terrault NA, HCV-TARGET.: Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function. Liver Int. 2016 Jun; 2016 Mar 24. PMID: 26923436

Njei B, Gupta N, Ewelukwa O, Ditah I, Foma M, Lim JK: Comparative efficacy of antiviral therapy in preventing vertical transmission of hepatitis B: a network meta-analysis. Liver Int. 2016 May; 2015 Oct 1. PMID: 26352650

Ahn J, Nguyen MH, Lim JK, Lee HM, Pan CQ, Lok AS: Letter: lessons from the 'real-world' entecavir therapy in chronic hepatitis B patients--authors' reply. Aliment Pharmacol Ther. 2016 Apr. PMID: 26932418

Reau N, Fried MW, Nelson DR, Brown RS Jr, Everson GT, Gordon SC, Jacobson IM, Lim JK, Pockros PJ, Reddy KR, Sherman KE: HCV Council--critical appraisal of data: recommendations for clinical practice in a rapidly evolving therapeutic landscape. Liver Int. 2016 Apr; 2015 Nov 22. PMID: 26509462

Yee BE, Nguyen NH, Jin M, Lutchman G, Lim JK, Nguyen MH: Lower response to simeprevir and sofosbuvir in HCV genotype 1 in routine practice compared with clinical trials. BMJ Open Gastroenterol. 2016; 2016 Mar 2. PMID: 26966547

Sulkowski MS, Vargas HE, Di Bisceglie AM, Kuo A, Reddy KR, Lim JK, Morelli G, Darling JM, Feld JJ, Brown RS, Frazier LM, Stewart TG, Fried MW, Nelson DR, Jacobson IM, HCV-TARGET Study Group.: Effectiveness of Simeprevir Plus Sofosbuvir, With or Without Ribavirin, in Real-World Patients With HCV Genotype 1 Infection. Gastroenterology. 2016 Feb; 2015 Oct 21. PMID: 26497081

Nguyen NH, Yee BE, Chang C, Jin M, Lutchman G, Lim JK, Nguyen MH: Tolerability and effectiveness of sofosbuvir and simeprevir in the post-transplant setting: systematic review and meta-analysis. BMJ Open Gastroenterol. 2016; 2016 Jan 4. PMID: 26966549

Ahn J, Lee HM, Lim JK, Pan CQ, Nguyen MH, Ray Kim W, Mannalithara A, Trinh H, Chu D, Tran T, Min A, Do S, Te H, Reddy KR, Lok AS: Entecavir safety and effectiveness in a national cohort of treatment-naïve chronic hepatitis B patients in the US - the ENUMERATE study. Aliment Pharmacol Ther. 2016 Jan; 2015 Oct 28. PMID: 26510638

Sarkar S, Mitchell KA, Lim JK, Oikonomou I, Jakab S: Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C. ACG Case Rep J. 2015 Oct; 2015 Oct 9. PMID: 26504877

Aaltonen T, Abazov VM, Abbott B, Acharya BS, Adams M, Adams T, Agnew JP, Alexeev GD, Alkhazov G, Alton A, Amerio S, Amidei D, Anastassov A, Annovi A, Antos J, Apollinari G, Appel JA, Arisawa T, Artikov A, Asaadi J, Ashmanskas W, Askew A, Atkins S, Auerbach B, Augsten K, Aurisano A, Avila C, Azfar F, Badaud F, Badgett W, Bae T, Bagby L, Baldin B, Bandurin DV, Banerjee S, Barbaro-Galtieri A, Barberis E, Baringer P, Barnes VE, Barnett BA, Barria P, Bartlett JF, Bartos P, Bassler U, Bauce M, Bazterra V, Bean A, Bedeschi F, Begalli M, Behari S, Bellantoni L, Bellettini G, Bellinger J, Benjamin D, Beretvas A, Beri SB, Bernardi G, Bernhard R, Bertram I, Besançon M, Beuselinck R, Bhat PC, Bhatia S, Bhatnagar V, Bhatti A, Bland KR, Blazey G, Blessing S, Bloom K, Blumenfeld B, Bocci A, Bodek A, Boehnlein A, Boline D, Boos EE, Borissov G, Bortoletto D, Borysova M, Boudreau J, Boveia A, Brandt A, Brandt O, Brigliadori L, Brock R, Bromberg C, Bross A, Brown D, Brucken E, Bu XB, Budagov J, Budd HS, Buehler M, Buescher V, Bunichev V, Burdin S, Burkett K, Busetto G, Bussey P, Buszello CP, Butti P, Buzatu A, Calamba A, Camacho-Pérez E, Camarda S, Campanelli M, Canelli F, Carls B, Carlsmith D, Carosi R, Carrillo S, Casal B, Casarsa M, Casey BC, Castilla-Valdez H, Castro A, Catastini P, Caughron S, Cauz D, Cavaliere V, Cerri A, Cerrito L, Chakrabarti S, Chan KM, Chandra A, Chapon E, Chen G, Chen YC, Chertok M, Chiarelli G, Chlachidze G, Cho K, Cho SW, Choi S, Chokheli D, Choudhary B, Cihangir S, Claes D, Clark A, Clarke C, Clutter J, Convery ME, Conway J, Cooke M, Cooper WE, Corbo M, Corcoran M, Cordelli M, Couderc F, Cousinou MC, Cox CA, Cox DJ, Cremonesi M, Cruz D, Cuevas J, Culbertson R, Cutts D, Das A, d'Ascenzo N, Datta M, Davies G, de Barbaro P, de Jong SJ, De La Cruz-Burelo E, Déliot F, Demina R, Demortier L, Deninno M, Denisov D, Denisov SP, D'Errico M, Desai S, Deterre C, DeVaughan K, Devoto F, Di Canto A, Di Ruzza B, Diehl HT, Diesburg M, Ding PF, Dittmann JR, Dominguez A, Donati S, D'Onofrio M, Dorigo M, Driutti A, Dubey A, Dudko LV, Duperrin A, Dutt S, Eads M, Ebina K, Edgar R, Edmunds D, Elagin A, Ellison J, Elvira VD, Enari Y, Erbacher R, Errede S, Esham B, Evans H, Evdokimov A, Evdokimov VN, Farrington S, Fauré A, Feng L, Ferbel T, Fernández Ramos JP, Fiedler F, Field R, Filthaut F, Fisher W, Fisk HE, Flanagan G, Forrest R, Fortner M, Fox H, Franklin M, Freeman JC, Frisch H, Fuess S, Funakoshi Y, Galloni C, Garbincius PH, Garcia-Bellido A, García-González JA, Garfinkel AF, Garosi P, Gavrilov V, Geng W, Gerber CE, Gerberich H, Gerchtein E, Gershtein Y, Giagu S, Giakoumopoulou V, Gibson K, Ginsburg CM, Ginther G, Giokaris N, Giromini P, Glagolev V, Glenzinski D, Gogota O, Gold M, Goldin D, Golossanov A, Golovanov G, Gomez G, Gomez-Ceballos G, Goncharov M, González López O, Gorelov I, Goshaw AT, Goulianos K, Gramellini E, Grannis PD, Greder S, Greenlee H, Grenier G, Gris P, Grivaz JF, Grohsjean A, Grosso-Pilcher C, Group RC, Grünendahl S, Grünewald MW, Guillemin T, Guimaraes da Costa J, Gutierrez G, Gutierrez P, Hahn SR, Haley J, Han JY, Han L, Happacher F, Hara K, Harder K, Hare M, Harel A, Harr RF, Harrington-Taber T, Hatakeyama K, Hauptman JM, Hays C, Hays J, Head T, Hebbeker T, Hedin D, Hegab H, Heinrich J, Heinson AP, Heintz U, Hensel C, Heredia-De La Cruz I, Herndon M, Herner K, Hesketh G, Hildreth MD, Hirosky R, Hoang T, Hobbs JD, Hocker A, Hoeneisen B, Hogan J, Hohlfeld M, Holzbauer JL, Hong Z, Hopkins W, Hou S, Howley I, Hubacek Z, Hughes RE, Husemann U, Hussein M, Huston J, Hynek V, Iashvili I, Ilchenko Y, Illingworth R, Introzzi G, Iori M, Ito AS, Ivanov A, Jabeen S, Jaffré M, James E, Jang D, Jayasinghe A, Jayatilaka B, Jeon EJ, Jeong MS, Jesik R, Jiang P, Jindariani S, Johns K, Johnson E, Johnson M, Jonckheere A, Jones M, Jonsson P, Joo KK, Joshi J, Jun SY, Jung AW, Junk TR, Juste A, Kajfasz E, Kambeitz M, Kamon T, Karchin PE, Karmanov D, Kasmi A, Kato Y, Katsanos I, Kaur M, Kehoe R, Kermiche S, Ketchum W, Keung J, Khalatyan N, Khanov A, Kharchilava A, Kharzheev YN, Kilminster B, Kim DH, Kim HS, Kim JE, Kim MJ, Kim SH, Kim SB, Kim YJ, Kim YK, Kimura N, Kirby M, Kiselevich I, Knoepfel K, Kohli JM, Kondo K, Kong DJ, Konigsberg J, Kotwal AV, Kozelov AV, Kraus J, Kreps M, Kroll J, Kruse M, Kuhr T, Kumar A, Kupco A, Kurata M, Kurča T, Kuzmin VA, Laasanen AT, Lammel S, Lammers S, Lancaster M, Lannon K, Latino G, Lebrun P, Lee HS, Lee HS, Lee JS, Lee SW, Lee WM, Lei X, Lellouch J, Leo S, Leone S, Lewis JD, Li D, Li H, Li L, Li QZ, Lim JK, Limosani A, Lincoln D, Linnemann J, Lipaev VV, Lipeles E, Lipton R, Lister A, Liu H, Liu H, Liu Q, Liu T, Liu Y, Lobodenko A, Lockwitz S, Loginov A, Lokajicek M, Lopes de Sa R, Lucchesi D, Lucà A, Lueck J, Lujan P, Lukens P, Luna-Garcia R, Lungu G, Lyon AL, Lys J, Lysak R, Maciel AK, Madar R, Madrak R, Maestro P, Magaña-Villalba R, Malik S, Malik S, Malyshev VL, Manca G, Manousakis-Katsikakis A, Mansour J, Marchese L, Margaroli F, Marino P, Martínez-Ortega J, Matera K, Mattson ME, Mazzacane A, Mazzanti P, McCarthy R, McGivern CL, McNulty R, Mehta A, Mehtala P, Meijer MM, Melnitchouk A, Menezes D, Mercadante PG, Merkin M, Mesropian C, Meyer A, Meyer J, Miao T, Miconi F, Mietlicki D, Mitra A, Miyake H, Moed S, Moggi N, Mondal NK, Moon CS, Moore R, Morello MJ, Mukherjee A, Mulhearn M, Muller T, Murat P, Mussini M, Nachtman J, Nagai Y, Naganoma J, Nagy E, Nakano I, Napier A, Narain M, Nayyar R, Neal HA, Negret JP, Nett J, Neu C, Neustroev P, Nguyen HT, Nigmanov T, Nodulman L, Noh SY, Norniella O, Nunnemann T, Oakes L, Oh SH, Oh YD, Oksuzian I, Okusawa T, Orava R, Orduna J, Ortolan L, Osman N, Osta J, Pagliarone C, Pal A, Palencia E, Palni P, Papadimitriou V, Parashar N, Parihar V, Park SK, Parker W, Partridge R, Parua N, Patwa A, Pauletta G, Paulini M, Paus C, Penning B, Perfilov M, Peters Y, Petridis K, Petrillo G, Pétroff P, Phillips TJ, Piacentino G, Pianori E, Pilot J, Pitts K, Plager C, Pleier MA, Podstavkov VM, Pondrom L, Popov AV, Poprocki S, Potamianos K, Pranko A, Prewitt M, Price D, Prokopenko N, Prokoshin F, Ptohos F, Punzi G, Qian J, Quadt A, Quinn B, Ratoff PN, Razumov I, Redondo Fernández I, Renton P, Rescigno M, Rimondi F, Ripp-Baudot I, Ristori L, Rizatdinova F, Robson A, Rodriguez T, Rolli S, Rominsky M, Ronzani M, Roser R, Rosner JL, Ross A, Royon C, Rubinov P, Ruchti R, Ruffini F, Ruiz A, Russ J, Rusu V, Sajot G, Sakumoto WK, Sakurai Y, Sánchez-Hernández A, Sanders MP, Santi L, Santos AS, Sato K, Savage G, Saveliev V, Savitskyi M, Savoy-Navarro A, Sawyer L, Scanlon T, Schamberger RD, Scheglov Y, Schellman H, Schlabach P, Schmidt EE, Schwanenberger C, Schwarz T, Schwienhorst R, Scodellaro L, Scuri F, Seidel S, Seiya Y, Sekaric J, Semenov A, Severini H, Sforza F, Shabalina E, Shalhout SZ, Shary V, Shaw S, Shchukin AA, Shears T, Shepard PF, Shimojima M, Shochet M, Shreyber-Tecker I, Simak V, Simonenko A, Skubic P, Slattery P, Sliwa K, Smirnov D, Smith JR, Snider FD, Snow GR, Snow J, Snyder S, Söldner-Rembold S, Song H, Sonnenschein L, Sorin V, Soustruznik K, St Denis R, Stancari M, Stark J, Stentz D, Stoyanova DA, Strauss M, Strologas J, Sudo Y, Sukhanov A, Suslov I, Suter L, Svoisky P, Takemasa K, Takeuchi Y, Tang J, Tecchio M, Teng PK, Thom J, Thomson E, Thukral V, Titov M, Toback D, Tokar S, Tokmenin VV, Tollefson K, Tomura T, Tonelli D, Torre S, Torretta D, Totaro P, Trovato M, Tsai YT, Tsybychev D, Tuchming B, Tully C, Ukegawa F, Uozumi S, Uvarov L, Uvarov S, Uzunyan S, Van Kooten R, van Leeuwen WM, Varelas N, Varnes EW, Vasilyev IA, Vázquez F, Velev G, Vellidis C, Verkheev AY, Vernieri C, Vertogradov LS, Verzocchi M, Vesterinen M, Vidal M, Vilanova D, Vilar R, Vizán J, Vogel M, Vokac P, Volpi G, Wagner P, Wahl HD, Wallny R, Wang MH, Wang SM, Warchol J, Waters D, Watts G, Wayne M, Weichert J, Welty-Rieger L, Wester WC, Whiteson D, Wicklund AB, Wilbur S, Williams HH, Williams MR, Wilson GW, Wilson JS, Wilson P, Winer BL, Wittich P, Wobisch M, Wolbers S, Wolfe H, Wood DR, Wright T, Wu X, Wu Z, Wyatt TR, Xie Y, Yamada R, Yamamoto K, Yamato D, Yang S, Yang T, Yang UK, Yang YC, Yao WM, Yasuda T, Yatsunenko YA, Ye W, Ye Z, Yeh GP, Yi K, Yin H, Yip K, Yoh J, Yorita K, Yoshida T, Youn SW, Yu GB, Yu I, Yu JM, Zanetti AM, Zeng Y, Zennamo J, Zhao TG, Zhou B, Zhou C, Zhu J, Zielinski M, Zieminska D, Zivkovic L, Zucchelli S, CDF Collaboration., D0 Collaboration.: Tevatron Combination of Single-Top-Quark Cross Sections and Determination of the Magnitude of the Cabibbo-Kobayashi-Maskawa Matrix Element V_{tb}. Phys Rev Lett. 2015 Oct 9; 2015 Oct 7. PMID: 26550718

Meyer JP, Moghimi Y, Marcus R, Lim JK, Litwin AH, Altice FL: Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum. Int J Drug Policy. 2015 Oct; 2015 May 17. PMID: 26077144

Popov VB, Lim JK: Treatment of Nonalcoholic Fatty Liver Disease: The Role of Medical, Surgical, and Endoscopic Weight Loss. J Clin Transl Hepatol. 2015 Sep 28; 2015 Sep 15. PMID: 26623270

Do A, Mittal Y, Liapakis A, Cohen E, Chau H, Bertuccio C, Sapir D, Wright J, Eggers C, Drozd K, Ciarleglio M, Deng Y, Lim JK: Drug Authorization for Sofosbuvir/Ledipasvir (Harvoni) for Chronic HCV Infection in a Real-World Cohort: A New Barrier in the HCV Care Cascade. PLoS One. 2015; 2015 Aug 27. PMID: 26312999

Lo Re V 3rd, Kallan MJ, Tate JP, Lim JK, Goetz MB, Klein MB, Rimland D, Rodriguez-Barradas MC, Butt AA, Gibert CL, Brown ST, Park LS, Dubrow R, Reddy KR, Kostman JR, Justice AC, Localio AR: Predicting Risk of End-Stage Liver Disease in Antiretroviral-Treated Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Patients. Open Forum Infect Dis. 2015 Sep; 2015 Jul 9. PMID: 26284259

Aaltonen T, Abazov VM, Abbott B, Acharya BS, Adams M, Adams T, Agnew JP, Alexeev GD, Alkhazov G, Alton A, Amerio S, Amidei D, Anastassov A, Annovi A, Antos J, Apollinari G, Appel JA, Arisawa T, Artikov A, Asaadi J, Ashmanskas W, Askew A, Atkins S, Auerbach B, Augsten K, Aurisano A, Avila C, Azfar F, Badaud F, Badgett W, Bae T, Bagby L, Baldin B, Bandurin DV, Banerjee S, Barbaro-Galtieri A, Barberis E, Baringer P, Barnes VE, Barnett BA, Barria P, Bartlett JF, Bartos P, Bassler U, Bauce M, Bazterra V, Bean A, Bedeschi F, Begalli M, Behari S, Bellantoni L, Bellettini G, Bellinger J, Benjamin D, Beretvas A, Beri SB, Bernardi G, Bernhard R, Bertram I, Besançon M, Beuselinck R, Bhat PC, Bhatia S, Bhatnagar V, Bhatti A, Bland KR, Blazey G, Blessing S, Bloom K, Blumenfeld B, Bocci A, Bodek A, Boehnlein A, Boline D, Boos EE, Borissov G, Bortoletto D, Borysova M, Boudreau J, Boveia A, Brandt A, Brandt O, Brigliadori L, Brock R, Bromberg C, Bross A, Brown D, Brucken E, Bu XB, Budagov J, Budd HS, Buehler M, Buescher V, Bunichev V, Burdin S, Burkett K, Busetto G, Bussey P, Buszello CP, Butti P, Buzatu A, Calamba A, Camacho-Pérez E, Camarda S, Campanelli M, Canelli F, Carls B, Carlsmith D, Carosi R, Carrillo S, Casal B, Casarsa M, Casey BC, Castilla-Valdez H, Castro A, Catastini P, Caughron S, Cauz D, Cavaliere V, Cerri A, Cerrito L, Chakrabarti S, Chan KM, Chandra A, Chapon E, Chen G, Chen YC, Chertok M, Chiarelli G, Chlachidze G, Cho K, Cho SW, Choi S, Chokheli D, Choudhary B, Cihangir S, Claes D, Clark A, Clarke C, Clutter J, Convery ME, Conway J, Cooke M, Cooper WE, Corbo M, Corcoran M, Cordelli M, Couderc F, Cousinou MC, Cox CA, Cox DJ, Cremonesi M, Cruz D, Cuevas J, Culbertson R, Cutts D, Das A, d'Ascenzo N, Datta M, Davies G, de Barbaro P, de Jong SJ, De La Cruz-Burelo E, Déliot F, Demina R, Demortier L, Deninno M, Denisov D, Denisov SP, D'Errico M, Desai S, Deterre C, DeVaughan K, Devoto F, Di Canto A, Di Ruzza B, Diehl HT, Diesburg M, Ding PF, Dittmann JR, Dominguez A, Donati S, D'Onofrio M, Dorigo M, Driutti A, Dubey A, Dudko LV, Duperrin A, Dutt S, Eads M, Ebina K, Edgar R, Edmunds D, Elagin A, Ellison J, Elvira VD, Enari Y, Erbacher R, Errede S, Esham B, Evans H, Evdokimov VN, Farrington S, Fauré A, Feng L, Ferbel T, Fernández Ramos JP, Fiedler F, Field R, Filthaut F, Fisher W, Fisk HE, Flanagan G, Forrest R, Fortner M, Fox H, Franklin M, Freeman JC, Frisch H, Fuess S, Funakoshi Y, Galloni C, Garbincius PH, Garcia-Bellido A, García-González JA, Garfinkel AF, Garosi P, Gavrilov V, Geng W, Gerber CE, Gerberich H, Gerchtein E, Gershtein Y, Giagu S, Giakoumopoulou V, Gibson K, Ginsburg CM, Ginther G, Giokaris N, Giromini P, Glagolev V, Glenzinski D, Gogota O, Gold M, Goldin D, Golossanov A, Golovanov G, Gomez G, Gomez-Ceballos G, Goncharov M, González López O, Gorelov I, Goshaw AT, Goulianos K, Gramellini E, Grannis PD, Greder S, Greenlee H, Grenier G, Gris P, Grivaz JF, Grohsjean A, Grosso-Pilcher C, Group RC, Grünendahl S, Grünewald MW, Guillemin T, Guimaraes da Costa J, Gutierrez G, Gutierrez P, Hahn SR, Haley J, Han JY, Han L, Happacher F, Hara K, Harder K, Hare M, Harel A, Harr RF, Harrington-Taber T, Hatakeyama K, Hauptman JM, Hays C, Hays J, Head T, Hebbeker T, Hedin D, Hegab H, Heinrich J, Heinson AP, Heintz U, Hensel C, Heredia-De La Cruz I, Herndon M, Herner K, Hesketh G, Hildreth MD, Hirosky R, Hoang T, Hobbs JD, Hocker A, Hoeneisen B, Hogan J, Hohlfeld M, Holzbauer JL, Hong Z, Hopkins W, Hou S, Howley I, Hubacek Z, Hughes RE, Husemann U, Hussein M, Huston J, Hynek V, Iashvili I, Ilchenko Y, Illingworth R, Introzzi G, Iori M, Ito AS, Ivanov A, Jabeen S, Jaffré M, James E, Jang D, Jayasinghe A, Jayatilaka B, Jeon EJ, Jeong MS, Jesik R, Jiang P, Jindariani S, Johns K, Johnson E, Johnson M, Jonckheere A, Jones M, Jonsson P, Joo KK, Joshi J, Jun SY, Jung AW, Junk TR, Juste A, Kajfasz E, Kambeitz M, Kamon T, Karchin PE, Karmanov D, Kasmi A, Kato Y, Katsanos I, Kaur M, Kehoe R, Kermiche S, Ketchum W, Keung J, Khalatyan N, Khanov A, Kharchilava A, Kharzheev YN, Kilminster B, Kim DH, Kim HS, Kim JE, Kim MJ, Kim SH, Kim SB, Kim YJ, Kim YK, Kimura N, Kirby M, Kiselevich I, Knoepfel K, Kohli JM, Kondo K, Kong DJ, Konigsberg J, Kotwal AV, Kozelov AV, Kraus J, Kreps M, Kroll J, Kruse M, Kuhr T, Kumar A, Kupco A, Kurata M, Kurča T, Kuzmin VA, Laasanen AT, Lammel S, Lammers S, Lancaster M, Lannon K, Latino G, Lebrun P, Lee HS, Lee HS, Lee JS, Lee SW, Lee WM, Lei X, Lellouch J, Leo S, Leone S, Lewis JD, Li D, Li H, Li L, Li QZ, Lim JK, Limosani A, Lincoln D, Linnemann J, Lipaev VV, Lipeles E, Lipton R, Lister A, Liu H, Liu H, Liu Q, Liu T, Liu Y, Lobodenko A, Lockwitz S, Loginov A, Lokajicek M, Lopes de Sa R, Lucchesi D, Lucà A, Lueck J, Lujan P, Lukens P, Luna-Garcia R, Lungu G, Lyon AL, Lys J, Lysak R, Maciel AK, Madar R, Madrak R, Maestro P, Magaña-Villalba R, Malik S, Malik S, Malyshev VL, Manca G, Manousakis-Katsikakis A, Mansour J, Marchese L, Margaroli F, Marino P, Martínez-Ortega J, Matera K, Mattson ME, Mazzacane A, Mazzanti P, McCarthy R, McGivern CL, McNulty R, Mehta A, Mehtala P, Meijer MM, Melnitchouk A, Menezes D, Mercadante PG, Merkin M, Mesropian C, Meyer A, Meyer J, Miao T, Miconi F, Mietlicki D, Mitra A, Miyake H, Moed S, Moggi N, Mondal NK, Moon CS, Moore R, Morello MJ, Mukherjee A, Mulhearn M, Muller T, Murat P, Mussini M, Nachtman J, Nagai Y, Naganoma J, Nagy E, Nakano I, Napier A, Narain M, Nayyar R, Neal HA, Negret JP, Nett J, Neu C, Neustroev P, Nguyen HT, Nigmanov T, Nodulman L, Noh SY, Norniella O, Nunnemann T, Oakes L, Oh SH, Oh YD, Oksuzian I, Okusawa T, Orava R, Orduna J, Ortolan L, Osman N, Osta J, Pagliarone C, Pal A, Palencia E, Palni P, Papadimitriou V, Parashar N, Parihar V, Park SK, Parker W, Partridge R, Parua N, Patwa A, Pauletta G, Paulini M, Paus C, Penning B, Perfilov M, Peters Y, Petridis K, Petrillo G, Pétroff P, Phillips TJ, Piacentino G, Pianori E, Pilot J, Pitts K, Plager C, Pleier MA, Podstavkov VM, Pondrom L, Popov AV, Poprocki S, Potamianos K, Pranko A, Prewitt M, Price D, Prokopenko N, Prokoshin F, Ptohos F, Punzi G, Qian J, Quadt A, Quinn B, Ratoff PN, Razumov I, Redondo Fernández I, Renton P, Rescigno M, Rimondi F, Ripp-Baudot I, Ristori L, Rizatdinova F, Robson A, Rodriguez T, Rolli S, Rominsky M, Ronzani M, Roser R, Rosner JL, Ross A, Royon C, Rubinov P, Ruchti R, Ruffini F, Ruiz A, Russ J, Rusu V, Sajot G, Sakumoto WK, Sakurai Y, Sánchez-Hernández A, Sanders MP, Santi L, Santos AS, Sato K, Savage G, Saveliev V, Savitskyi M, Savoy-Navarro A, Sawyer L, Scanlon T, Schamberger RD, Scheglov Y, Schellman H, Schlabach P, Schmidt EE, Schwanenberger C, Schwarz T, Schwienhorst R, Scodellaro L, Scuri F, Seidel S, Seiya Y, Sekaric J, Semenov A, Severini H, Sforza F, Shabalina E, Shalhout SZ, Shary V, Shaw S, Shchukin AA, Shears T, Shepard PF, Shimojima M, Shochet M, Shreyber-Tecker I, Simak V, Simonenko A, Skubic P, Slattery P, Sliwa K, Smirnov D, Smith JR, Snider FD, Snow GR, Snow J, Snyder S, Söldner-Rembold S, Song H, Sonnenschein L, Sorin V, Soustruznik K, St Denis R, Stancari M, Stark J, Stentz D, Stoyanova DA, Strauss M, Strologas J, Sudo Y, Sukhanov A, Suslov I, Suter L, Svoisky P, Takemasa K, Takeuchi Y, Tang J, Tecchio M, Teng PK, Thom J, Thomson E, Thukral V, Titov M, Toback D, Tokar S, Tokmenin VV, Tollefson K, Tomura T, Tonelli D, Torre S, Torretta D, Totaro P, Trovato M, Tsai YT, Tsybychev D, Tuchming B, Tully C, Ukegawa F, Uozumi S, Uvarov L, Uvarov S, Uzunyan S, Van Kooten R, van Leeuwen WM, Varelas N, Varnes EW, Vasilyev IA, Vázquez F, Velev G, Vellidis C, Verkheev AY, Vernieri C, Vertogradov LS, Verzocchi M, Vesterinen M, Vidal M, Vilanova D, Vilar R, Vizán J, Vogel M, Vokac P, Volpi G, Wagner P, Wahl HD, Wallny R, Wang MH, Wang SM, Warchol J, Waters D, Watts G, Wayne M, Weichert J, Welty-Rieger L, Wester WC, Whiteson D, Wicklund AB, Wilbur S, Williams HH, Williams MR, Wilson GW, Wilson JS, Wilson P, Winer BL, Wittich P, Wobisch M, Wolbers S, Wolfe H, Wood DR, Wright T, Wu X, Wu Z, Wyatt TR, Xie Y, Yamada R, Yamamoto K, Yamato D, Yang S, Yang T, Yang UK, Yang YC, Yao WM, Yasuda T, Yatsunenko YA, Ye W, Ye Z, Yeh GP, Yi K, Yin H, Yip K, Yoh J, Yorita K, Yoshida T, Youn SW, Yu GB, Yu I, Yu JM, Zanetti AM, Zeng Y, Zennamo J, Zhao TG, Zhou B, Zhou C, Zhu J, Zielinski M, Zieminska D, Zivkovic L, Zucchelli S, CDF Collaboration., D0 Collaboration.: Tevatron constraints on models of the Higgs boson with exotic spin and parity using decays to bottom-antibottom quark pairs. Phys Rev Lett. 2015 Apr 17; 2015 Apr 15. PMID: 25933309

Gordon SC, Muir AJ, Lim JK, Pearlman B, Argo CK, Ramani A, Maliakkal B, Alam I, Stewart TG, Vainorius M, Peter J, Nelson DR, Fried MW, Reddy KR, HCV-TARGET study group.: Safety profile of boceprevir and telaprevir in chronic hepatitis C: real world experience from HCV-TARGET. J Hepatol. 2015 Feb; 2014 Sep 10. PMID: 25218788

Reddy KR, Beavers KL, Hammond SP, Lim JK, Falck-Ytter YT, American Gastroenterological Association Institute.: American Gastroenterological Association Institute guideline on the prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy. Gastroenterology. 2015 Jan; 2014 Oct 31. PMID: 25447850

Njei B, Rotman Y, Ditah I, Lim JK: Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology. 2015 Jan; 2014 Nov 24. PMID: 25142309

Lim JK: Advancing the science and practice of gastroenterology and hepatology. BMJ Open Gastroenterol. 2014; 2015 Feb 6. PMID: 26462268

Lawitz E, Sulkowski MS, Ghalib R, Rodriguez-Torres M, Younossi ZM, Corregidor A, DeJesus E, Pearlman B, Rabinovitz M, Gitlin N, Lim JK, Pockros PJ, Scott JD, Fevery B, Lambrecht T, Ouwerkerk-Mahadevan S, Callewaert K, Symonds WT, Picchio G, Lindsay KL, Beumont M, Jacobson IM: Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study. Lancet. 2014 Nov 15; 2014 Jul 28. PMID: 25078309

Lo Re V 3rd, Tate JP, Lim JK, Fiellin DA, Justice AC: Reply to Marcellin et al. Clin Infect Dis. 2014 Oct 15; 2014 Jul 11. PMID: 25015914

Nguyen LH, Chao D, Lim JK, Ayoub W, Nguyen MH: Histologic changes in liver tissue from patients with chronic hepatitis B and minimal increases in levels of alanine aminotransferase: a meta-analysis and systematic review. Clin Gastroenterol Hepatol. 2014 Aug; 2013 Dec 17. PMID: 24361419

Aaltonen T, Abazov VM, Abbott B, Acharya BS, Adams M, Adams T, Agnew JP, Alexeev GD, Alkhazov G, Alton A, Amerio S, Amidei D, Anastassov A, Annovi A, Antos J, Apollinari G, Appel JA, Arisawa T, Artikov A, Asaadi J, Ashmanskas W, Askew A, Atkins S, Auerbach B, Augsten K, Aurisano A, Avila C, Azfar F, Badaud F, Badgett W, Bae T, Bagby L, Baldin B, Bandurin DV, Banerjee S, Barbaro-Galtieri A, Barberis E, Baringer P, Barnes VE, Barnett BA, Barria P, Bartlett JF, Bartos P, Bassler U, Bauce M, Bazterra V, Bean A, Bedeschi F, Begalli M, Behari S, Bellantoni L, Bellettini G, Bellinger J, Benjamin D, Beretvas A, Beri SB, Bernardi G, Bernhard R, Bertram I, Besançon M, Beuselinck R, Bhat PC, Bhatia S, Bhatnagar V, Bhatti A, Bland KR, Blazey G, Blessing S, Bloom K, Blumenfeld B, Bocci A, Bodek A, Boehnlein A, Boline D, Boos EE, Borissov G, Bortoletto D, Borysova M, Boudreau J, Boveia A, Brandt A, Brandt O, Brigliadori L, Brock R, Bromberg C, Bross A, Brown D, Brucken E, Bu XB, Budagov J, Budd HS, Buehler M, Buescher V, Bunichev V, Burdin S, Burkett K, Busetto G, Bussey P, Buszello CP, Butti P, Buzatu A, Calamba A, Camacho-Pérez E, Camarda S, Campanelli M, Canelli F, Carls B, Carlsmith D, Carosi R, Carrillo S, Casal B, Casarsa M, Casey BC, Castilla-Valdez H, Castro A, Catastini P, Caughron S, Cauz D, Cavaliere V, Cavalli-Sforza M, Cerri A, Cerrito L, Chakrabarti S, Chan KM, Chandra A, Chapon E, Chen G, Chen YC, Chertok M, Chiarelli G, Chlachidze G, Cho K, Cho SW, Choi S, Chokheli D, Choudhary B, Cihangir S, Claes D, Clark A, Clarke C, Clutter J, Convery ME, Conway J, Cooke M, Cooper WE, Corbo M, Corcoran M, Cordelli M, Couderc F, Cousinou MC, Cox CA, Cox DJ, Cremonesi M, Cruz D, Cuevas J, Culbertson R, Cutts D, Das A, d'Ascenzo N, Datta M, Davies G, de Barbaro P, de Jong SJ, De La Cruz-Burelo E, Déliot F, Demina R, Demortier L, Deninno M, Denisov D, Denisov SP, D'Errico M, Desai S, Deterre C, DeVaughan K, Devoto F, Di Canto A, Di Ruzza B, Diehl HT, Diesburg M, Ding PF, Dittmann JR, Dominguez A, Donati S, D'Onofrio M, Dorigo M, Driutti A, Dubey A, Dudko LV, Duperrin A, Dutt S, Eads M, Ebina K, Edgar R, Edmunds D, Elagin A, Ellison J, Elvira VD, Enari Y, Erbacher R, Errede S, Esham B, Evans H, Evdokimov VN, Farrington S, Feng L, Ferbel T, Fernández Ramos JP, Fiedler F, Field R, Filthaut F, Fisher W, Fisk HE, Flanagan G, Forrest R, Fortner M, Fox H, Franklin M, Freeman JC, Frisch H, Fuess S, Funakoshi Y, Galloni C, Garbincius PH, Garcia-Bellido A, García-González JA, Garfinkel AF, Garosi P, Gavrilov V, Geng W, Gerber CE, Gerberich H, Gerchtein E, Gershtein Y, Giagu S, Giakoumopoulou V, Gibson K, Ginsburg CM, Ginther G, Giokaris N, Giromini P, Giurgiu G, Glagolev V, Glenzinski D, Gold M, Goldin D, Golossanov A, Golovanov G, Gomez G, Gomez-Ceballos G, Goncharov M, González López O, Gorelov I, Goshaw AT, Goulianos K, Gramellini E, Grannis PD, Greder S, Greenlee H, Grenier G, Grinstein S, Gris P, Grivaz JF, Grohsjean A, Grosso-Pilcher C, Group RC, Grünendahl S, Grünewald MW, Guillemin T, Guimaraes da Costa J, Gutierrez G, Gutierrez P, Hahn SR, Haley J, Han JY, Han L, Happacher F, Hara K, Harder K, Hare M, Harel A, Harr RF, Harrington-Taber T, Hatakeyama K, Hauptman JM, Hays C, Hays J, Head T, Hebbeker T, Hedin D, Hegab H, Heinrich J, Heinson AP, Heintz U, Hensel C, Heredia-De La Cruz I, Herndon M, Herner K, Hesketh G, Hildreth MD, Hirosky R, Hoang T, Hobbs JD, Hocker A, Hoeneisen B, Hogan J, Hohlfeld M, Holzbauer JL, Hong Z, Hopkins W, Hou S, Howley I, Hubacek Z, Hughes RE, Husemann U, Hussein M, Huston J, Hynek V, Iashvili I, Ilchenko Y, Illingworth R, Introzzi G, Iori M, Ito AS, Ivanov A, Jabeen S, Jaffré M, James E, Jang D, Jayasinghe A, Jayatilaka B, Jeon EJ, Jeong MS, Jesik R, Jiang P, Jindariani S, Johns K, Johnson E, Johnson M, Jonckheere A, Jones M, Jonsson P, Joo KK, Joshi J, Jun SY, Jung AW, Junk TR, Juste A, Kajfasz E, Kambeitz M, Kamon T, Karchin PE, Karmanov D, Kasmi A, Kato Y, Katsanos I, Kehoe R, Kermiche S, Ketchum W, Keung J, Khalatyan N, Khanov A, Kharchilava A, Kharzheev YN, Kilminster B, Kim DH, Kim HS, Kim JE, Kim MJ, Kim SH, Kim SB, Kim YJ, Kim YK, Kimura N, Kirby M, Kiselevich I, Knoepfel K, Kohli JM, Kondo K, Kong DJ, Konigsberg J, Kotwal AV, Kozelov AV, Kraus J, Kreps M, Kroll J, Kruse M, Kuhr T, Kumar A, Kupco A, Kurata M, Kurča T, Kuzmin VA, Laasanen AT, Lammel S, Lammers S, Lancaster M, Lannon K, Latino G, Lebrun P, Lee HS, Lee HS, Lee JS, Lee SW, Lee WM, Lei X, Lellouch J, Leo S, Leone S, Lewis JD, Li D, Li H, Li L, Li QZ, Lim JK, Limosani A, Lincoln D, Linnemann J, Lipaev VV, Lipeles E, Lipton R, Lister A, Liu H, Liu H, Liu Q, Liu T, Liu Y, Lobodenko A, Lockwitz S, Loginov A, Lokajicek M, Lopes de Sa R, Lucchesi D, Lucà A, Lueck J, Lujan P, Lukens P, Luna-Garcia R, Lungu G, Lyon AL, Lys J, Lysak R, Maciel AK, Madar R, Madrak R, Maestro P, Magaña-Villalba R, Malik S, Malik S, Malyshev VL, Manca G, Manousakis-Katsikakis A, Mansour J, Marchese L, Margaroli F, Marino P, Martínez-Ortega J, Martínez M, Matera K, Mattson ME, Mazzacane A, Mazzanti P, McCarthy R, McGivern CL, McNulty R, Mehta A, Mehtala P, Meijer MM, Melnitchouk A, Menezes D, Mercadante PG, Merkin M, Mesropian C, Meyer A, Meyer J, Miao T, Miconi F, Mietlicki D, Mitra A, Miyake H, Moed S, Moggi N, Mondal NK, Moon CS, Moore R, Morello MJ, Mukherjee A, Mulhearn M, Muller T, Murat P, Mussini M, Nachtman J, Nagai Y, Naganoma J, Nagy E, Nakano I, Napier A, Narain M, Nayyar R, Neal HA, Negret JP, Nett J, Neu C, Neustroev P, Nguyen HT, Nigmanov T, Nodulman L, Noh SY, Norniella O, Nunnemann T, Oakes L, Oh SH, Oh YD, Oksuzian I, Okusawa T, Orava R, Orduna J, Ortolan L, Osman N, Osta J, Pagliarone C, Pal A, Palencia E, Palni P, Papadimitriou V, Parashar N, Parihar V, Park SK, Parker W, Partridge R, Parua N, Patwa A, Pauletta G, Paulini M, Paus C, Penning B, Perfilov M, Peters Y, Petridis K, Petrillo G, Pétroff P, Phillips TJ, Piacentino G, Pianori E, Pilot J, Pitts K, Plager C, Pleier MA, Podstavkov VM, Pondrom L, Popov AV, Poprocki S, Potamianos K, Pranko A, Prewitt M, Price D, Prokopenko N, Prokoshin F, Ptohos F, Punzi G, Qian J, Quadt A, Quinn B, Ranjan N, Ratoff PN, Razumov I, Redondo Fernández I, Renton P, Rescigno M, Rimondi F, Ripp-Baudot I, Ristori L, Rizatdinova F, Robson A, Rodriguez T, Rolli S, Rominsky M, Ronzani M, Roser R, Rosner JL, Ross A, Royon C, Rubinov P, Ruchti R, Ruffini F, Ruiz A, Russ J, Rusu V, Sajot G, Sakumoto WK, Sakurai Y, Sánchez-Hernández A, Sanders MP, Santi L, Santos AS, Sato K, Savage G, Saveliev V, Savoy-Navarro A, Sawyer L, Scanlon T, Schamberger RD, Scheglov Y, Schellman H, Schlabach P, Schmidt EE, Schwanenberger C, Schwarz T, Schwienhorst R, Scodellaro L, Scuri F, Seidel S, Seiya Y, Sekaric J, Semenov A, Severini H, Sforza F, Shabalina E, Shalhout SZ, Shary V, Shaw S, Shchukin AA, Shears T, Shepard PF, Shimojima M, Shochet M, Shreyber-Tecker I, Simak V, Simonenko A, Skubic P, Slattery P, Sliwa K, Smirnov D, Smith JR, Snider FD, Snow GR, Snow J, Snyder S, Söldner-Rembold S, Song H, Sonnenschein L, Sorin V, Soustruznik K, St Denis R, Stancari M, Stark J, Stentz D, Stoyanova DA, Strauss M, Strologas J, Sudo Y, Sukhanov A, Suslov I, Suter L, Svoisky P, Takemasa K, Takeuchi Y, Tang J, Tecchio M, Teng PK, Thom J, Thomson E, Thukral V, Titov M, Toback D, Tokar S, Tokmenin VV, Tollefson K, Tomura T, Tonelli D, Torre S, Torretta D, Totaro P, Trovato M, Tsai YT, Tsybychev D, Tuchming B, Tully C, Ukegawa F, Uozumi S, Uvarov L, Uvarov S, Uzunyan S, Van Kooten R, van Leeuwen WM, Varelas N, Varnes EW, Vasilyev IA, Vázquez F, Velev G, Vellidis C, Verkheev AY, Vernieri C, Vertogradov LS, Verzocchi M, Vesterinen M, Vidal M, Vilanova D, Vilar R, Vizán J, Vogel M, Vokac P, Volpi G, Wagner P, Wahl HD, Wallny R, Wang MH, Wang SM, Warchol J, Waters D, Watts G, Wayne M, Weichert J, Welty-Rieger L, Wester WC 3rd, Whiteson D, Wicklund AB, Wilbur S, Williams HH, Williams MR, Wilson GW, Wilson JS, Wilson P, Winer BL, Wittich P, Wobisch M, Wolbers S, Wolfe H, Wood DR, Wright T, Wu X, Wu Z, Wyatt TR, Xie Y, Yamada R, Yamamoto K, Yamato D, Yang S, Yang T, Yang UK, Yang YC, Yao WM, Yasuda T, Yatsunenko YA, Ye W, Ye Z, Yeh GP, Yi K, Yin H, Yip K, Yoh J, Yorita K, Yoshida T, Youn SW, Yu GB, Yu I, Yu JM, Zanetti AM, Zeng Y, Zennamo J, Zhao TG, Zhou B, Zhou C, Zhu J, Zielinski M, Zieminska D, Zivkovic L, Zucchelli S, CDF Collaboration., D0 Collaboration.: Observation of s-channel production of single top quarks at the Tevatron. Phys Rev Lett. 2014 Jun 13; 2014 Jun 9. PMID: 24972197

Sarkar S, Lim JK: Advances in interferon-free hepatitis C therapy: 2014 and beyond. Hepatology. 2014 Apr; 2014 Mar 3. PMID: 24590916

Liapakis A, Lim JK: Impact of rapid point-of-care screening tests for the identification of chronic hepatitis C infection. Hepatology. 2013 Aug. PMID: 23744577

Belcher JM, Garcia-Tsao G, Sanyal AJ, Bhogal H, Lim JK, Ansari N, Coca SG, Parikh CR, TRIBE-AKI Consortium.: Association of AKI with mortality and complications in hospitalized patients with cirrhosis. Hepatology. 2013 Feb; 2012 Dec 6. PMID: 22454364

Bolen CR, Robek MD, Brodsky L, Schulz V, Lim JK, Taylor MW, Kleinstein SH: The blood transcriptional signature of chronic hepatitis C virus is consistent with an ongoing interferon-mediated antiviral response. J Interferon Cytokine Res. 2013 Jan; 2012 Oct 15. PMID: 23067362

Assis DN, Lim JK: New pharmacotherapy for hepatitis C. Clin Pharmacol Ther. 2012 Sep; 2012 Aug 1. PMID: 22850602

Bruce RD, Eiserman J, Acosta A, Gote C, Lim JK, Altice FL: Developing a modified directly observed therapy intervention for hepatitis C treatment in a methadone maintenance program: implications for program replication. Am J Drug Alcohol Abuse. 2012 May; 2012 Jan 13. PMID: 22242700

Porto AF, Tormey L, Lim JK: Management of chronic hepatitis C infection in children. Curr Opin Pediatr. 2012 Feb. PMID: 22157364

Park LS, Tate JP, Justice AC, Lo Re V 3rd, Lim JK, Bräu N, Brown ST, Butt AA, Gibert C, Goetz MB, Rimland D, Rodriguez-Barradas MC, Dubrow R: FIB-4 index is associated with hepatocellular carcinoma risk in HIV-infected patients. Cancer Epidemiol Biomarkers Prev. 2011 Dec; 2011 Oct 25. PMID: 22028407

Garcia-Tsao G, Lim JK, Members of Veterans Affairs Hepatitis C Resource Center Program.: Management and treatment of patients with cirrhosis and portal hypertension: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program. Am J Gastroenterol. 2009 Jul; 2009 May 19. PMID: 19455106

Sheth AA, Lim JK: Liver disease from asymptomatic constrictive pericarditis. J Clin Gastroenterol. 2008 Sep. PMID: 18385605

Cheun BS, Yi SH, Baik KY, Lim JK, Yoo JS, Shin HW, soh KS: Biophoton emission of MDCK cell with hydrogen peroxide and 60 Hz AC magnetic field. J Environ Biol. 2007 Oct. PMID: 18405105

Lim JK, Kraus ML, Giles SS: Lupus cerebritis and steroid psychosis in mixed connective tissue disorder. Yale J Biol Med. 2004 May. PMID: 15829147

Lim JK: Natural history of hepatitis C infection: a concise review. Yale J Biol Med. 2001 Jul-Aug. PMID: 11697481

Xavier Llor, MD, PhD

Kandimalla R, Linnekamp JF, van Hooff S, Castells A, Llor X, Andreu M, Jover R, Goel A, Medema JP: Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. Oncogenesis. 2017 Apr 3; 2017 Apr 3. PMID: 28368388

Yazici C, Wolf PG, Kim H, Cross TL, Vermillion K, Carroll T, Augustus GJ, Mutlu E, Tussing-Humphreys L, Braunschweig C, Xicola RM, Jung B, Llor X, Ellis NA, Gaskins HR: Race-dependent association of sulfidogenic bacteria with colorectal cancer. Gut. 2017 Feb 2; 2017 Feb 2. PMID: 28153960

Llor X: Building a Cancer Genetics and Prevention Program. Clin Gastroenterol Hepatol. 2016 Nov; 2016 Aug 13. PMID: 27531499

Xicola RM, Bontu S, Doyle BJ, Rawson J, Garre P, Lee E, de la Hoya M, Bessa X, Clofent J, Bujanda L, Balaguer F, Castellví-Bel S, Alenda C, Jover R, Ruiz-Ponte C, Syngal S, Andreu M, Carracedo A, Castells A, Newcomb PA, Lindor N, Potter JD, Baron JA, Ellis NA, Caldes T, LLor X: Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). Carcinogenesis. 2016 Aug; 2016 May 27. PMID: 27234654

Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL: Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. Mol Cancer Res. 2016 Jun; 2016 Mar 16. PMID: 26983689

Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M: A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget. 2016 Apr 23. PMID: 27120810

Hamaya Y, Guarinos C, Tseng-Rogenski SS, Iwaizumi M, Das R, Jover R, Castells A, Llor X, Andreu M, Carethers JM: Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer. PLoS One. 2015; 2015 May 21. PMID: 25996601

Hulur I, Gamazon ER, Skol AD, Xicola RM, Llor X, Onel K, Ellis NA, Kupfer SS: Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC Genomics. 2015 Feb 27; 2015 Feb 27. PMID: 25766683

Xicola RM, Gagnon M, Clark JR, Carroll T, Gao W, Fernandez C, Mijic D, Rawson JB, Janoski A, Pusatcioglu CK, Rajaram P, Gluskin AB, Regan M, Chaudhry V, Abcarian H, Blumetti J, Cintron J, Melson J, Xie H, Guzman G, Emmadi R, Alagiozian-Angelova V, Kupfer SS, Braunschweig C, Ellis NA, Llor X: Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multiethnic study. Clin Cancer Res. 2014 Sep 15; 2014 Jul 10. PMID: 25013126

Llor X: Colorectal cancer: from the laboratory to the patient, a now indispensable step. Rev Gastroenterol Mex. 2014 Apr-Jun. PMID: 24934514

Amir Masoud, MBBS

Sharma P, Balasingham S, Stawiarski K, Rahmani M, Costantino A, Sharma P, Xu M, Masoud A: Burkitt lymphoma as a lead point for jejunojejunal intussusception in a human immunodeficiency virus patient. Clin J Gastroenterol. 2017 Aug; 2017 May 18. PMID: 28523628

Wajahat Zafar Mehal, PhD, MD

Yang AM, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, Kisseleva T, Torralba MG, Moncera K, Beeri K, Chen CS, Freese K, Hellerbrand C, Lee SM, Hoffman HM, Mehal WZ, Garcia-Tsao G, Mutlu EA, Keshavarzian A, Brown GD, Ho SB, Bataller R, Stärkel P, Fouts DE, Schnabl B: Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017 Jun 30; 2017 May 22. PMID: 28530644

Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL: Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714

Shaker ME, Trawick BN, Mehal WZ: The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers. Biochem Pharmacol. 2016 Jul 15; 2016 May 6. PMID: 27157410

Mehal WZ: We are not in Kansas anymore: The unfamiliar landscape of NASH. Hepatology. 2016 Mar; 2016 Jan 5. PMID: 26567082

Wree A, Mehal WZ, Feldstein AE: Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis. Semin Liver Dis. 2016 Feb; 2016 Feb 12. PMID: 26870930

Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ, Saleh M: Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance. J Immunol. 2016 Jan 1; 2015 Nov 18. PMID: 26582949

Garcia-Martinez I, Shaker ME, Mehal WZ: Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases. Antioxid Redox Signal. 2015 Dec 10; 2015 Jul 27. PMID: 26055926

Michelena J, Altamirano J, Abraldes JG, Affò S, Morales-Ibanez O, Sancho-Bru P, Dominguez M, García-Pagán JC, Fernández J, Arroyo V, Ginès P, Louvet A, Mathurin P, Mehal WZ, Caballería J, Bataller R: Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis. Hepatology. 2015 Sep; 2015 Apr 13. PMID: 25761863

Mehal WZ, Schuppan D: Antifibrotic therapies in the liver. Semin Liver Dis. 2015 May; 2015 May 14. PMID: 25974903

Hoque R, Mehal WZ: Inflammasomes in pancreatic physiology and disease. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 2015 Feb 19. PMID: 25700081

Garcia-Martinez I, Mehal WZ: DNA: adding injury to insult. Hepatology. 2015 Jan; 2014 Nov 26. PMID: 25145786

Farooq A, Hoque R, Ouyang X, Farooq A, Ghani A, Ahsan K, Guerra M, Mehal WZ: Activation of N-methyl-d-aspartate receptor downregulates inflammasome activity and liver inflammation via a β-arrestin-2 pathway. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 1; 2014 Aug 7. PMID: 25104498

Hoque R, Farooq A, Ghani A, Gorelick F, Mehal WZ: Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology. 2014 Jun; 2014 Mar 20. PMID: 24657625

Ahsan MK, Mehal WZ: Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb. Front Pharmacol. 2014; 2014 Apr 10. PMID: 24782773

Mehal WZ: Who is the scientist in bio-medical research, the author or the reviewer? Front Pharmacol. 2014; 2014 Mar 26. PMID: 24723888

Mehal WZ: Constitutive NLRP3 activation: too much of a bad thing. Hepatology. 2014 Mar; 2014 Jan 13. PMID: 23929761

Mehal WZ: The inflammasome in liver injury and non-alcoholic fatty liver disease. Dig Dis. 2014; 2014 Jul 14. PMID: 25034283

Mehal WZ: The Gordian Knot of dysbiosis, obesity and NAFLD. Nat Rev Gastroenterol Hepatol. 2013 Nov; 2013 Aug 20. PMID: 23958600

Shaker ME, Ghani A, Shiha GE, Ibrahim TM, Mehal WZ: Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases. Biochim Biophys Acta. 2013 Aug; 2013 Mar 13. PMID: 23499874

Hoque R, Farooq A, Mehal WZ: Sterile inflammation in the liver and pancreas. J Gastroenterol Hepatol. 2013 Aug. PMID: 23855298

Ouyang X, Ghani A, Mehal WZ: Inflammasome biology in fibrogenesis. Biochim Biophys Acta. 2013 Jul; 2013 Apr 3. PMID: 23562491

Ouyang X, Ghani A, Malik A, Wilder T, Colegio OR, Flavell RA, Cronstein BN, Mehal WZ: Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway. Nat Commun. 2013. PMID: 24352507

Watanabe A, Sohail MA, Gautam S, Gomes DA, Mehal WZ: Adenine induces differentiation of rat hepatic stellate cells. Dig Dis Sci. 2012 Sep; 2012 May 10. PMID: 22573344

Chung RT, Stravitz RT, Fontana RJ, Schiodt FV, Mehal WZ, Reddy KR, Lee WM: Pathogenesis of liver injury in acute liver failure. Gastroenterology. 2012 Sep; 2012 Jul 13. PMID: 22796239

Liu J, Halene S, Yang M, Iqbal J, Yang R, Mehal WZ, Chuang WL, Jain D, Yuen T, Sun L, Zaidi M, Mistry PK: Gaucher disease gene GBA functions in immune regulation. Proc Natl Acad Sci U S A. 2012 Jun 19; 2012 Jun 4. PMID: 22665763

Hoque R, Sohail MA, Salhanick S, Malik AF, Ghani A, Robson SC, Mehal WZ: P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice. Am J Physiol Gastrointest Liver Physiol. 2012 May 15; 2012 Mar 1. PMID: 22383490

Hoque R, Malik AF, Gorelick F, Mehal WZ: Sterile inflammatory response in acute pancreatitis. Pancreas. 2012 Apr. PMID: 22415665

Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 2012 Feb 1; 2012 Feb 1. PMID: 22297845

Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ: Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc Natl Acad Sci U S A. 2011 Dec 13; 2011 Nov 22. PMID: 22109549

Mehal WZ, Iredale J, Friedman SL: Scraping fibrosis: expressway to the core of fibrosis. Nat Med. 2011 May. PMID: 21546973

Mistry PK, Liu J, Yang M, Nottoli T, McGrath J, Jain D, Zhang K, Keutzer J, Chuang WL, Mehal WZ, Zhao H, Lin A, Mane S, Liu X, Peng YZ, Li JH, Agrawal M, Zhu LL, Blair HC, Robinson LJ, Iqbal J, Sun L, Zaidi M: Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proc Natl Acad Sci U S A. 2010 Nov 9; 2010 Oct 20. PMID: 20962279

Zipprich A, Mehal WZ, Ripoll C, Groszmann RJ: A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver. Liver Int. 2010 Aug; 2010 May 24. PMID: 20500549

Mohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ: Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells. Hepatology. 2010 Mar. PMID: 20044808

Watanabe A, Sohail MA, Gomes DA, Hashmi A, Nagata J, Sutterwala FS, Mahmood S, Jhandier MN, Shi Y, Flavell RA, Mehal WZ: Inflammasome-mediated regulation of hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2009 Jun; 2009 Apr 9. PMID: 19359429

Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ: Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest. 2009 Feb; 2009 Jan 26. PMID: 19164858

Sohail MA, Hashmi AZ, Hakim W, Watanabe A, Zipprich A, Groszmann RJ, Dranoff JA, Torok NJ, Mehal WZ: Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition. Hepatology. 2009 Jan. PMID: 18844235

Watanabe A, Hashmi A, Gomes DA, Town T, Badou A, Flavell RA, Mehal WZ: Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology. 2007 Nov. PMID: 17705260

Hashmi AZ, Hakim W, Kruglov EA, Watanabe A, Watkins W, Dranoff JA, Mehal WZ: Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 2006 Oct 19. PMID: 17053161

Badou A, Jha MK, Matza D, Mehal WZ, Freichel M, Flockerzi V, Flavell RA: Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proc Natl Acad Sci U S A. 2006 Oct 17; 2006 Oct 6. PMID: 17028169

Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA: Modulation of cell adhesion and motility in the immune system by Myo1f. Science. 2006 Oct 6. PMID: 17023661

Qamar A, Sheikh SZ, Masud A, Jhandier MN, Inayat IB, Hakim W, Mehal WZ: In vitro and in vivo protection of stellate cells from apoptosis by leptin. Dig Dis Sci. 2006 Oct. PMID: 16957995

Lakhani SA, Masud A, Kuida K, Porter GA Jr, Booth CJ, Mehal WZ, Inayat I, Flavell RA: Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science. 2006 Feb 10. PMID: 16469926

Kuniyasu Y, Qamar A, Sheikh SZ, Jhandier MN, Hakim W, Mehal WZ: Blocking intrahepatic deletion of activated CD8+ T cells by an altered peptide ligand. Cell Immunol. 2005 Nov; 2006 Jan 30. PMID: 16445896

Mehal WZ, Sheikh SZ, Gorelik L, Flavell RA: TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions. Int Immunol. 2005 May; 2005 Apr 11. PMID: 15824070

Badou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA: Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. Science. 2005 Jan 7. PMID: 15637280

Kuniyasu Y, Marfani SM, Inayat IB, Sheikh SZ, Mehal WZ: Kupffer cells required for high affinity peptide-induced deletion, not retention, of activated CD8+ T cells by mouse liver. Hepatology. 2004 Apr. PMID: 15057906

Li MO, Sarkisian MR, Mehal WZ, Rakic P, Flavell RA: Phosphatidylserine receptor is required for clearance of apoptotic cells. Science. 2003 Nov 28. PMID: 14645847

Mehal WZ, Azzaroli F, Crispe IN: Antigen presentation by liver cells controls intrahepatic T cell trapping, whereas bone marrow-derived cells preferentially promote intrahepatic T cell apoptosis. J Immunol. 2001 Jul 15. PMID: 11441069

Dao T, Exley M, Mehal WZ, Tahir SM, Snapper S, Taniguchi M, Balk SP, Crispe IN: Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. J Immunol. 2001 Mar 1. PMID: 11207260

Mehal WZ, Azzaroli F, Crispe IN: Immunology of the healthy liver: old questions and new insights. Gastroenterology. 2001 Jan. PMID: 11208734

Crispe IN, Dao T, Klugewitz K, Mehal WZ, Metz DP: The liver as a site of T-cell apoptosis: graveyard, or killing field? Immunol Rev. 2000 Apr. PMID: 10807506

Mehal WZ, Juedes AE, Crispe IN: Selective retention of activated CD8+ T cells by the normal liver. J Immunol. 1999 Sep 15. PMID: 10477588

Dao T, Mehal WZ, Crispe IN: IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells. J Immunol. 1998 Sep 1. PMID: 9725214

Mehal WZ, Crispe IN: TCR ligation on CD8+ T cells creates double-negative cells in vivo. J Immunol. 1998 Aug 15. PMID: 9712032

Crispe IN, Mehal WZ: Strange brew: T cells in the liver. Immunol Today. 1996 Nov. PMID: 8961629

Thiruvengadam Muniraj, MD, MRCP

Muniraj T, Aslanian HR: New Developments in Endoscopic Ultrasound Tissue Acquisition. Gastrointest Endosc Clin N Am. 2017 Oct. PMID: 28918800

Bellin MD, Whitcomb DC, Abberbock J, Sherman S, Sandhu BS, Gardner TB, Anderson MA, Lewis MD, Alkaade S, Singh VK, Baillie J, Banks PA, Conwell D, Cote GA, Guda NM, Muniraj T, Tang G, Brand RE, Gelrud A, Amann ST, Forsmark CE, Wilcox CM, Slivka A, Yadav D: Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States. Am J Gastroenterol. 2017 Sep; 2017 Jul 25. PMID: 28741615

Machicado JD, Amann ST, Anderson MA, Abberbock J, Sherman S, Conwell DL, Cote GA, Singh VK, Lewis MD, Alkaade S, Sandhu BS, Guda NM, Muniraj T, Tang G, Baillie J, Brand RE, Gardner TB, Gelrud A, Forsmark CE, Banks PA, Slivka A, Wilcox CM, Whitcomb DC, Yadav D: Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities. Am J Gastroenterol. 2017 Apr; 2017 Feb 28. PMID: 28244497

Gnanapandithan K, Karthik N, Muniraj T: Pancreatic Tail Neoplasm Masquerading as Recurrent Splenic Abscesses. J Gastrointest Cancer. 2017 Mar 28; 2017 Mar 28. PMID: 28349307

Muniraj T, Jamidar PA, Nealon WH, Aslanian HR: Endoscopic Management of Pancreatic Fluid Collections. J Clin Gastroenterol. 2017 Jan. PMID: 27548730

Wilcox CM, Sandhu BS, Singh V, Gelrud A, Abberbock JN, Sherman S, Cote GA, Al-Kaade S, Anderson MA, Gardner TB, Lewis MD, Forsmark CE, Guda NM, Romagnuolo J, Baillie J, Amann ST, Muniraj T, Tang G, Conwell DL, Banks PA, Brand RE, Slivka A, Whitcomb D, Yadav D: Racial Differences in the Clinical Profile, Causes, and Outcome of Chronic Pancreatitis. Am J Gastroenterol. 2016 Oct; 2016 Aug 16. PMID: 27527745

Fox RK, Muniraj T: Pharmacologic Therapies in Gastrointestinal Diseases. Med Clin North Am. 2016 Jul. PMID: 27235617

Muniraj T, Aslanian HR: Awash in a Multitude of Pancreas Cysts: Can We Stop Looking? Clin Gastroenterol Hepatol. 2016 Jun; 2016 Feb 4. PMID: 26851707

Muniraj T, Dang S, Pitchumoni CS: PANCREATITIS OR NOT?--Elevated lipase and amylase in ICU patients. J Crit Care. 2015 Dec; 2015 Sep 1. PMID: 26411523

Muniraj T, Aslanian HR, Laine L, Farrell J, Ciarleglio MM, Deng Y, Ho H, Jamidar PA: A double-blind, randomized, sham-controlled trial of the effect of a radiation-attenuating drape on radiation exposure to endoscopy staff during ERCP. Am J Gastroenterol. 2015 May; 2015 Mar 31. PMID: 25823765

Muniraj T, Sahakian A, Ciarleglio MM, Deng Y, Aslanian HR: Cold snare polypectomy for large sessile colonic polyps: a single-center experience. Gastroenterol Res Pract. 2015; 2015 Mar 23. PMID: 25878658

Muniraj T, Vignesh S, Shetty S, Thiruvengadam S, Aslanian HR: Pancreatic neuroendocrine tumors. Dis Mon. 2013 Jan. PMID: 23312533

Muniraj T, Barve P: Laparoscopic staging and surgical treatment of pancreatic cancer. N Am J Med Sci. 2013 Jan. PMID: 23378948

Muniraj T, Chari ST: Diabetes and pancreatic cancer. Minerva Gastroenterol Dietol. 2012 Dec. PMID: 23207610

Muniraj T, Aslanian HR: Hypertriglyceridemia independent propofol-induced pancreatitis. JOP. 2012 Jul 10; 2012 Jul 10. PMID: 22797405

Michael Harris Nathanson, MD, PhD

Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X: Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation. Genes Dev. 2017 Sep 13; 2017 Sep 13. PMID: 28903979

Iwakiri Y, Nathanson MH: Alcohol and calcium make a potent cocktail. J Physiol. 2017 May 15; 2017 Apr 18. PMID: 28295353

Kruglov E, Ananthanarayanan M, Sousa P, Weerachayaphorn J, Guerra MT, Nathanson MH: Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP. Biochem Biophys Res Commun. 2017 May 6; 2017 Mar 19. PMID: 28327356

Khamphaya T, Chansela P, Piyachaturawat P, Suksamrarn A, Nathanson MH, Weerachayaphorn J: Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats. Eur J Pharmacol. 2016 Oct 15; 2016 Jul 27. PMID: 27475677

Nathanson MH, Terrault N: Hepatitis B surface antigen loss: Not all that we hoped it would be. Hepatology. 2016 Aug; 2016 Jun 16. PMID: 27178231

Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH: Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes. Gastroenterology. 2015 Jul; 2015 Mar 18. PMID: 25796361

Guerra MT, Nathanson MH: Calcium signaling and secretion in cholangiocytes. Pancreatology. 2015 Jul; 2015 Jun 12. PMID: 26100660

Nathanson MH: What is Hepatology looking for? Hepatology. 2015 Apr; 2015 Mar 10. PMID: 25581014

Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH: Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506. J Biol Chem. 2015 Jan 2; 2014 Nov 5. PMID: 25378392

Feriod CN, Nguyen L, Jurczak MJ, Kruglov EA, Nathanson MH, Shulman GI, Bennett AM, Ehrlich BE: Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II. Am J Physiol Endocrinol Metab. 2014 Dec 1; 2014 Oct 14. PMID: 25315698

Amaya MJ, Oliveira AG, Schroeder LK, Allgeyer ES, Bewersdorf J, Nathanson MH: Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes. PLoS One. 2014; 2014 Dec 1. PMID: 25437447

Amaya MJ, Nathanson MH: Calcium signaling and the secretory activity of bile duct epithelia. Cell Calcium. 2014 Jun; 2014 Feb 12. PMID: 24612866

Chen J, Wong S, Nathanson MH, Jain D: Evaluation of Barrett esophagus by multiphoton microscopy. Arch Pathol Lab Med. 2014 Feb. PMID: 24476518

Amaya MJ, Oliveira AG, Guimarães ES, Casteluber MC, Carvalho SM, Andrade LM, Pinto MC, Mennone A, Oliveira CA, Resende RR, Menezes GB, Nathanson MH, Leite MF: The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology. 2014 Jan; 2013 Jul 29. PMID: 23839970

Amaya MJ, Nathanson MH: Calcium signaling in the liver. Compr Physiol. 2013 Jan. PMID: 23720295

Shieh FK, Drumm H, Nathanson MH, Jamidar PA: High-definition confocal endomicroscopy of the common bile duct. J Clin Gastroenterol. 2012 May-Jun. PMID: 22011583

Kruglov EA, Gautam S, Guerra MT, Nathanson MH: Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes. Hepatology. 2011 Nov; 2011 Aug 30. PMID: 21748767

Andrade V, Guerra M, Jardim C, Melo F, Silva W, Ortega JM, Robert M, Nathanson MH, Leite F: Nucleoplasmic calcium regulates cell proliferation through legumain. J Hepatol. 2011 Sep; 2011 Jan 13. PMID: 21237226

Loeser CS, Robert ME, Mennone A, Nathanson MH, Jamidar P: Confocal endomicroscopic examination of malignant biliary strictures and histologic correlation with lymphatics. J Clin Gastroenterol. 2011 Mar. PMID: 21063210

Mennone A, Nathanson MH: Needle-based confocal laser endomicroscopy to assess liver histology in vivo. Gastrointest Endosc. 2011 Feb; 2010 Dec 8. PMID: 21145055

Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH: Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling. J Biol Chem. 2011 Jan 21; 2010 Nov 17. PMID: 21084290

Fiedler MJ, Nathanson MH: The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca waves. Neurosignals. 2011; 2011 Mar 10. PMID: 21389686

Cruz LN, Guerra MT, Kruglov E, Mennone A, Garcia CR, Chen J, Nathanson MH: Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. Hepatology. 2010 Jul. PMID: 20578149

Soliman EM, Rodrigues MA, Gomes DA, Sheung N, Yu J, Amaya MJ, Nathanson MH, Dranoff JA: Intracellular calcium signals regulate growth of hepatic stellate cells via specific effects on cell cycle progression. Cell Calcium. 2009 Mar; 2009 Jan 7. PMID: 19131107

Rodrigues MA, Gomes DA, Andrade VA, Leite MF, Nathanson MH: Insulin induces calcium signals in the nucleus of rat hepatocytes. Hepatology. 2008 Nov. PMID: 18798337

Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM, Nathanson MH: c-Met must translocate to the nucleus to initiate calcium signals. J Biol Chem. 2008 Feb 15; 2007 Dec 11. PMID: 18073207

Rogart JN, Nagata J, Loeser CS, Roorda RD, Aslanian H, Robert ME, Zipfel WR, Nathanson MH: Multiphoton imaging can be used for microscopic examination of intact human gastrointestinal mucosa ex vivo. Clin Gastroenterol Hepatol. 2008 Jan; 2007 Dec 18. PMID: 18065276

Minagawa N, Nagata J, Shibao K, Masyuk AI, Gomes DA, Rodrigues MA, Lesage G, Akiba Y, Kaunitz JD, Ehrlich BE, Larusso NF, Nathanson MH: Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Gastroenterology. 2007 Nov; 2007 Aug 14. PMID: 17916355

Garcia-Tsao G, Nathanson MH: Portal hypertension: from the patient to the molecule and back: a symposium honoring Roberto J. Groszmann, MD. J Clin Gastroenterol. 2007 Nov-Dec. PMID: 17975470

Correa PR, Kruglov EA, Thompson M, Leite MF, Dranoff JA, Nathanson MH: Succinate is a paracrine signal for liver damage. J Hepatol. 2007 Aug; 2007 Apr 5. PMID: 17451837

Nagata J, Guerra MT, Shugrue CA, Gomes DA, Nagata N, Nathanson MH: Lipid rafts establish calcium waves in hepatocytes. Gastroenterology. 2007 Jul; 2007 Apr 11. PMID: 17631147

Rodrigues MA, Gomes DA, Leite MF, Grant W, Zhang L, Lam W, Cheng YC, Bennett AM, Nathanson MH: Nucleoplasmic calcium is required for cell proliferation. J Biol Chem. 2007 Jun 8; 2007 Apr 9. PMID: 17420246

Husain SZ, Grant WM, Gorelick FS, Nathanson MH, Shah AU: Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 2007 Mar 1. PMID: 17332472

Kruglov EA, Correa PR, Arora G, Yu J, Nathanson MH, Dranoff JA: Molecular basis for calcium signaling in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2007 Apr; 2007 Jan 4. PMID: 17204544

Hernandez E, Leite MF, Guerra MT, Kruglov EA, Bruna-Romero O, Rodrigues MA, Gomes DA, Giordano FJ, Dranoff JA, Nathanson MH: The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves. J Biol Chem. 2007 Mar 30; 2007 Feb 6. PMID: 17284437

O'Brien EM, Gomes DA, Sehgal S, Nathanson MH: Hormonal regulation of nuclear permeability. J Biol Chem. 2007 Feb 9; 2006 Dec 7. PMID: 17158097

Minagawa N, Ehrlich BE, Nathanson MH: Calcium signaling in cholangiocytes. World J Gastroenterol. 2006 Jun 14. PMID: 16773703

Marius P, Guerra MT, Nathanson MH, Ehrlich BE, Leite MF: Calcium release from ryanodine receptors in the nucleoplasmic reticulum. Cell Calcium. 2006 Jan; 2005 Nov 9. PMID: 16289270

Sehgal S, Guerra MT, Kruglov EA, Wang J, Nathanson MH: Protein 4.1N does not interact with the inositol 1,4,5-trisphosphate receptor in an epithelial cell line. Cell Calcium. 2005 Nov. PMID: 16122796

Husain SZ, Prasad P, Grant WM, Kolodecik TR, Nathanson MH, Gorelick FS: The ryanodine receptor mediates early zymogen activation in pancreatitis. Proc Natl Acad Sci U S A. 2005 Oct 4; 2005 Sep 26. PMID: 16186498

Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GJ, Nathanson MH: The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals. J Biol Chem. 2005 Sep 30; 2005 Jul 18. PMID: 16027162

Correa PR, Guerra MT, Leite MF, Spray DC, Nathanson MH: Endotoxin unmasks the role of gap junctions in the liver. Biochem Biophys Res Commun. 2004 Sep 24. PMID: 15336523

Shibao K, Hirata K, Robert ME, Nathanson MH: Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis. Gastroenterology. 2003 Oct. PMID: 14517800

Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH: Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol. 2003 May. PMID: 12717445

Hirata K, Dufour JF, Shibao K, Knickelbein R, O'Neill AF, Bode HP, Cassio D, St-Pierre MV, Larusso NF, Leite MF, Nathanson MH: Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms. Hepatology. 2002 Aug. PMID: 12143036

Pusl T, Wu JJ, Zimmerman TL, Zhang L, Ehrlich BE, Berchtold MW, Hoek JB, Karpen SJ, Nathanson MH, Bennett AM: Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem. 2002 Jul 26; 2002 Apr 23. PMID: 11971908

O'Neill AF, Hagar RE, Zipfel WR, Nathanson MH, Ehrlich BE: Regulation of the type III InsP(3) receptor by InsP(3) and calcium. Biochem Biophys Res Commun. 2002 Jun 14. PMID: 12056830

Hirata K, Pusl T, O'Neill AF, Dranoff JA, Nathanson MH: The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes. Gastroenterology. 2002 Apr. PMID: 11910359

Hamita Sachar, MD

Sachar H, Pichetshote N, Nandigam K, Vaidya K, Laine L: Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial. Gastrointest Endosc. 2017 Jan 31; 2017 Jan 31. PMID: 28159539

Michael Schilsky, MD

Koch DG, Speiser JL, Durkalski V, Fontana RJ, Davern T, McGuire B, Stravitz RT, Larson AM, Liou I, Fix O, Schilsky ML, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Brown RS, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hanje AJ, Olson J, Subramanian RM, Karvellas C, Hameed B, Sherker AH, Lee WM, Reuben A: The Natural History of Severe Acute Liver Injury. Am J Gastroenterol. 2017 Sep; 2017 Apr 25. PMID: 28440304

Pfeiffenberger J, Beinhardt S, Gotthardt DN, Haag N, Freissmuth C, Reuner U, Gauss A, Stremmel W, Schilsky ML, Ferenci P, Weiss KH: Pregnancy in Wilson disease - management and outcome. Hepatology. 2017 Aug 31; 2017 Aug 31. PMID: 28859232

Boga S, Ala A, Schilsky ML: Hepatic features of Wilson disease. Handb Clin Neurol. 2017. PMID: 28433114

Graper ML, Schilsky ML: Patient support groups in the management of Wilson disease. Handb Clin Neurol. 2017. PMID: 28433107

Ahmad A, Torrazza-Perez E, Schilsky ML: Liver transplantation for Wilson disease. Handb Clin Neurol. 2017. PMID: 28433103

Schindler EA, Guo XM, Schrag M, Ghoshal S, Schilsky ML, Beslow LA: Neuropsychiatric Presentation of Wilson Disease in an Adolescent Male. Neuropediatrics. 2016 Oct; 2016 Aug 4. PMID: 27490186

Karvellas CJ, Tillman H, Leung AA, Lee WM, Schilsky ML, Hameed B, Stravitz RT, McGuire BM, Fix OK, United States Acute Liver Failure Study Group.: Acute liver injury and acute liver failure from mushroom poisoning in North America. Liver Int. 2016 Jul; 2016 Mar 4. PMID: 26837055

Boga S, Munoz-Abraham AS, Rodriguez-Davalos MI, Emre SH, Jain D, Schilsky ML: Host factors are dominant in the development of post-liver transplant non-alcoholic steatohepatitis. World J Hepatol. 2016 May 28. PMID: 27239259

Schilsky ML, Moini M: Advances in liver transplantation allocation systems. World J Gastroenterol. 2016 Mar 14. PMID: 26973389

Roy-Chowdhury J, Schilsky ML: Gene therapy of Wilson disease: A "golden" opportunity using rAAV on the 50th anniversary of the discovery of the virus. J Hepatol. 2016 Feb; 2015 Nov 27. PMID: 26639392

Boga S, Jain D, Schilsky ML: Trientine induced colitis during therapy for Wilson disease: a case report and review of the literature. BMC Pharmacol Toxicol. 2015 Nov 20; 2015 Nov 20. PMID: 26589720

Zimbrean PC, Schilsky ML: The spectrum of psychiatric symptoms in Wilson's disease: treatment and prognostic considerations. Am J Psychiatry. 2015 Nov 1. PMID: 26575449

Boga S, Jain D, Schilsky ML: Presentation of Progressive Familial Intrahepatic Cholestasis Type 3 Mimicking Wilson Disease: Molecular Genetic Diagnosis and Response to Treatment. Pediatr Gastroenterol Hepatol Nutr. 2015 Sep; 2015 Sep 25. PMID: 26473142

Karvellas CJ, Stravitz RT, Battenhouse H, Lee WM, Schilsky ML: Reply: To PMID 25308108. Liver Transpl. 2015 Jul. PMID: 25779618

Schilsky ML, Roberts EA, Hahn S, Askari F: Costly choices for treating Wilson's disease. Hepatology. 2015 Apr; 2015 Mar 10. PMID: 25524500

Schilsky ML: A century for progress in the diagnosis of Wilson disease. J Trace Elem Med Biol. 2014 Oct; 2014 Jul 4. PMID: 25087157

Schilsky ML: Liver transplantation for Wilson's disease. Ann N Y Acad Sci. 2014 May. PMID: 24820352

Schilsky ML: Long-term outcome for Wilson disease: 85% good. Clin Gastroenterol Hepatol. 2014 Apr; 2013 Nov 16. PMID: 24246766

Zimbrean PC, Schilsky ML: Psychiatric aspects of Wilson disease: a review. Gen Hosp Psychiatry. 2014 Jan-Feb; 2013 Oct 9. PMID: 24120023

Schilsky ML: Hepatitis B "360". Transplant Proc. 2013 Apr. PMID: 23622604

Schilsky ML: Transplantation for inherited metabolic disorders of the liver. Transplant Proc. 2013 Mar. PMID: 23498779

Assis DN, Pollak J, Schilsky ML, Emre S: Successful treatment of a bleeding umbilical varix by percutaneous umbilical vein embolization with sclerotherapy. J Clin Gastroenterol. 2012 Feb. PMID: 21897280

Schilsky ML: Acute liver failure and liver assist devices. Transplant Proc. 2011 Apr. PMID: 21486619

Assis DN, Schilsky ML: Testing and management of thrombocytopenia and coagulopathy in the pre- and postliver transplant patient. Minerva Gastroenterol Dietol. 2010 Sep. PMID: 21037549

Schilsky ML, Ala A: Genetic testing for Wilson disease: availability and utility. Curr Gastroenterol Rep. 2010 Feb. PMID: 20425485

Schilsky ML: Wilson disease: current status and the future. Biochimie. 2009 Oct; 2009 Jul 30. PMID: 19647032

Schilsky ML, Honiden S, Arnott L, Emre S: ICU management of acute liver failure. Clin Chest Med. 2009 Mar. PMID: 19186281

Marina Silveira, MD

Silveira MG, Lindor KD: Investigational drugs in phase II clinical trials for primary biliary cholangitis. Expert Opin Investig Drugs. 2017 Oct; 2017 Aug 31. PMID: 28836457

Carol J Soroka, PhD

Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL: Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight. 2017 Mar 9; 2017 Mar 9. PMID: 28289714

Li M, Soroka CJ, Harry K, Boyer JL: CFTR-associated ligand is a negative regulator of Mrp2 expression. Am J Physiol Cell Physiol. 2017 Jan 1; 2016 Nov 9. PMID: 27834195

Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL: Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis. Hepatology. 2016 Dec; 2016 Oct 28. PMID: 27639250

Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL: A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PLoS One. 2016; 2016 Jun 28. PMID: 27351185

Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL: Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology. 2015 Oct; 2015 Aug 22. PMID: 26108984

Soroka CJ, Boyer JL: Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations. Mol Aspects Med. 2014 Jun; 2013 May 15. PMID: 23685087

Cai SY, Mennone A, Soroka CJ, Boyer JL: Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 2014 Jan 30. PMID: 24481602

Cai SY, Mennone A, Soroka CJ, Boyer JL: All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice. J Pharmacol Exp Ther. 2014 Apr; 2014 Feb 3. PMID: 24492652

Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL: Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion. Hepatology. 2014 Mar; 2014 Jan 27. PMID: 24122873

Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL: Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. J Hepatol. 2014 Jan; 2013 Aug 23. PMID: 23978715

Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL: Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology. 2013 Jun. PMID: 23175353

Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM: Identification of functionally distinct Na-HCO3 co-transporters in colon. PLoS One. 2013; 2013 May 14. PMID: 23690961

Lam P, Xu S, Soroka CJ, Boyer JL: A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis. Hepatology. 2012 Jun; 2012 Apr 25. PMID: 22161577

Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL: Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am J Physiol Gastrointest Liver Physiol. 2012 May 1; 2012 Feb 16. PMID: 22345550

Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL: Ostα depletion protects liver from oral bile acid load. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 2011 Jun 30. PMID: 21719738

Mennone A, Soroka CJ, Harry KM, Boyer JL: Role of breast cancer resistance protein in the adaptive response to cholestasis. Drug Metab Dispos. 2010 Oct; 2010 Jul 2. PMID: 20601550

Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535

Li M, Wang W, Soroka CJ, Mennone A, Harry K, Weinman EJ, Boyer JL: NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem. 2010 Jun 18; 2010 Apr 19. PMID: 20404332

Soroka CJ, Ballatori N, Boyer JL: Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422499

Lam P, Soroka CJ, Boyer JL: The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease. Semin Liver Dis. 2010 May; 2010 Apr 26. PMID: 20422495

Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL: Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology. 2010 Jan. PMID: 19902485

Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression. Hepatology. 2009 Nov. PMID: 19821532

Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL: ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology. 2009 Mar; 2008 Nov 1. PMID: 19027009

Wang L, Dong H, Soroka CJ, Wei N, Boyer JL, Hochstrasser M: Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Hepatology. 2008 Nov. PMID: 18798335

Soroka CJ, Xu S, Mennone A, Lam P, Boyer JL: N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta. BMC Cell Biol. 2008 Oct 10; 2008 Oct 10. PMID: 18847488

Lam P, Pearson CL, Soroka CJ, Xu S, Mennone A, Boyer JL: Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases. Am J Physiol Cell Physiol. 2007 Nov; 2007 Sep 13. PMID: 17855769

Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL: Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression. Am J Physiol Gastrointest Liver Physiol. 2007 May; 2007 Feb 1. PMID: 17272513

Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, Boyer JL: Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes. Gastroenterology. 2006 Sep. PMID: 16952556

Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N: Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 2006 Jan 19. PMID: 16423920

Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL: Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology. 2006 May. PMID: 16628672

Denk GU, Cai SY, Chen WS, Lin A, Soroka CJ, Boyer JL: A comparison of gene expression in mouse liver and kidney in obstructive cholestasis utilizing high-density oligonucleotide microarray technology. World J Gastroenterol. 2006 Apr 28. PMID: 16688799

Denk GU, Soroka CJ, Mennone A, Koepsell H, Beuers U, Boyer JL: Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis. Hepatology. 2004 May. PMID: 15122767

Denk GU, Soroka CJ, Takeyama Y, Chen WS, Schuetz JD, Boyer JL: Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol. 2004 Apr. PMID: 15030973

Cai SY, Soroka CJ, Ballatori N, Boyer JL: Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate. Am J Physiol Regul Integr Comp Physiol. 2003 Jan; 2002 Oct 3. PMID: 12388433

Wang L, Soroka CJ, Boyer JL: The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II. J Clin Invest. 2002 Oct. PMID: 12370274

Azzaroli F, Mehal W, Soroka CJ, Wang L, Lee J, Crispe IN, Boyer JL: Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. Hepatology. 2002 Jul. PMID: 12085348

Cai SY, Wang W, Soroka CJ, Ballatori N, Boyer JL: An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins. Am J Physiol Gastrointest Liver Physiol. 2002 Apr. PMID: 11897630

Carlo Spirli, PhD

Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M: Emerging concepts in biliary repair and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690

Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L: The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma. Biochim Biophys Acta. 2017 Jul 27; 2017 Jul 27. PMID: 28757170

Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L: Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium. Biochim Biophys Acta. 2017 Jul 25; 2017 Jul 25. PMID: 28754453

Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M: Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves CFTR correctors efficacy. Hepatology. 2017 Jul 24; 2017 Jul 24. PMID: 28836688

Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M: Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057

Cadamuro M, Brivio S, Spirli C, Joplin RE, Strazzabosco M, Fabris L: Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma. Int J Mol Sci. 2017 Jan 13; 2017 Jan 13. PMID: 28098760

Fiorotto R, Villani A, Kourtidis A, Scirpo R, Amenduni M, Geibel PJ, Cadamuro M, Spirli C, Anastasiadis PZ, Strazzabosco M: The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity. Hepatology. 2016 Dec; 2016 Oct 27. PMID: 27629435

Cadamuro M, Spagnuolo G, Sambado L, Indraccolo S, Nardo G, Rosato A, Brivio S, Caslini C, Stecca T, Massani M, Bassi N, Novelli E, Spirli C, Fabris L, Strazzabosco M: Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma. Cancer Res. 2016 Aug 15; 2016 Jun 21. PMID: 27328733

Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M: Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994

Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M: Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562

Scirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M: Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium. Hepatology. 2015 Nov; 2015 Aug 28. PMID: 26199136

Saiman Y, Sugiyama T, Simchoni N, Spirli C, Bansal MB: Biliary Epithelial Cells Are Not the Predominant Source of Hepatic CXCL12. Am J Pathol. 2015 Jul; 2015 Apr 29. PMID: 25934614

Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH: Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes. Gastroenterology. 2015 Jul; 2015 Mar 18. PMID: 25796361

Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH: Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506. J Biol Chem. 2015 Jan 2; 2014 Nov 5. PMID: 25378392

Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M: Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology. 2013 Nov; 2013 Sep 30. PMID: 23744610

Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M: Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. J Hepatol. 2013 Jul; 2013 Mar 7. PMID: 23500150

Spirli C, Strazzabosco M: Vascular endothelial growth factors in progenitor cells mediated liver repair. Hepatobiliary Surg Nutr. 2013 Apr. PMID: 24570918

Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M: Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib. Hepatology. 2012 Dec; 2012 Aug 27. PMID: 22653837

Spirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M: Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes. Hepatology. 2012 Mar. PMID: 21987453

Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M: Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice. Gastroenterology. 2011 Oct; 2011 Jun 26. PMID: 21712022

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M: Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. Hepatology. 2010 May. PMID: 20131403

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M: ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology. 2010 Jan; 2009 Sep 18. PMID: 19766642

Strazzabosco M, Fiorotto R, Melero S, Glaser S, Francis H, Spirli C, Alpini G: Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Hepatology. 2009 Jul. PMID: 19444869

Yu J, Sheung N, Soliman EM, Spirli C, Dranoff JA: Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP. Am J Physiol Gastrointest Liver Physiol. 2009 Mar; 2009 Jan 8. PMID: 19136380

Fiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M: Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion. Gastroenterology. 2007 Nov; 2007 Sep 2. PMID: 17983806

Mario Strazzabosco, MD, PhD

Belli LS, Duvoux C, Berenguer M, Berg T, Coilly A, Colle I, Fagiuoli S, Khoo S, Pageaux GP, Puoti M, Samuel D, Strazzabosco M: ELITA consensus statements on the use of DAAs in liver transplant candidates and recipients. J Hepatol. 2017 Sep; 2017 Mar 18. PMID: 28323126

Carbone M, Cristoferi L, Cortesi PA, Rota M, Ciaccio A, Okolicsanyi S, Gemma M, Scalone L, Cesana G, Fabris L, Colledan M, Fagiuoli S, Ideo G, Belli LS, Munari LM, Mantovani L, Strazzabosco M: Optimising the clinical strategy for autoimmune liver diseases: Principles of value-based medicine. Biochim Biophys Acta. 2017 Aug 24; 2017 Aug 24. PMID: 28844954

Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M: Emerging concepts in biliary repair and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 2017 May 19. PMID: 28526690

Cadamuro M, Stecca T, Brivio S, Mariotti V, Fiorotto R, Spirli C, Strazzabosco M, Fabris L: The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma. Biochim Biophys Acta. 2017 Jul 27; 2017 Jul 27. PMID: 28757170

Strazzabosco M, Fiorotto R, Cadamuro M, Spirli C, Mariotti V, Kaffe E, Scirpo R, Fabris L: Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium. Biochim Biophys Acta. 2017 Jul 25; 2017 Jul 25. PMID: 28754453

Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M: Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves CFTR correctors efficacy. Hepatology. 2017 Jul 24; 2017 Jul 24. PMID: 28836688

Mariotti V, Strazzabosco M, Fabris L, Calvisi DF: Animal models of biliary injury and altered bile acid metabolism. Biochim Biophys Acta. 2017 Jul 11; 2017 Jul 11. PMID: 28709963

Ciaccio A, Cortesi PA, Bellelli G, Rota M, Conti S, Okolicsanyi S, Rota M, Cesana G, Mantovani LG, Annoni G, Strazzabosco M: Direct-acting antivirals combination for elderly patients with chronic hepatitis C: A cost-effectiveness analysis. Liver Int. 2017 Jul; 2017 Mar 2. PMID: 27943549

Ippolito D, Querques G, Okolicsanyi S, Franzesi CT, Strazzabosco M, Sironi S: Diagnostic value of dynamic contrast-enhanced CT with perfusion imaging in the quantitative assessment of tumor response to sorafenib in patients with advanced hepatocellular carcinoma: A feasibility study. Eur J Radiol. 2017 May; 2017 Feb 20. PMID: 28583645

Strazzabosco M, Allen JI, Teisberg EO: Value-based care in hepatology. Hepatology. 2017 May. PMID: 28073146

Spirli C, Mariotti V, Villani A, Fabris L, Fiorotto R, Strazzabosco M: Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease. J Hepatol. 2017 Mar; 2016 Nov 5. PMID: 27826057

Cadamuro M, Brivio S, Spirli C, Joplin RE, Strazzabosco M, Fabris L: Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma. Int J Mol Sci. 2017 Jan 13; 2017 Jan 13. PMID: 28098760

De Carlis L, Di Sandro S, Centonze L, Lauterio A, Buscemi V, De Carlis R, Ferla F, Sguinzi R, Okolicsanyi S, Belli L, Strazzabosco M: Liver-allocation policies for patients affected by HCC in Europe. Curr Transplant Rep. 2016 Dec; 2016 Oct 7. PMID: 28473952

Fiorotto R, Villani A, Kourtidis A, Scirpo R, Amenduni M, Geibel PJ, Cadamuro M, Spirli C, Anastasiadis PZ, Strazzabosco M: The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity. Hepatology. 2016 Dec; 2016 Oct 27. PMID: 27629435

Mantovani LG, Cortesi PA, Strazzabosco M: Effective but costly: How to tackle difficult trade-offs in evaluating health improving technologies in liver diseases. Hepatology. 2016 Oct; 2016 Apr 4. PMID: 26926906

Belli LS, Berenguer M, Cortesi PA, Strazzabosco M, Rockenschaub SR, Martini S, Morelli C, Donato F, Volpes R, Pageaux GP, Coilly A, Fagiuoli S, Amaddeo G, Perricone G, Vinaixa C, Berlakovich G, Facchetti R, Polak W, Muiesan P, Duvoux C, European Liver and Intestine Association (ELITA).: Delisting of liver transplant candidates with chronic hepatitis C after viral eradication: A European study. J Hepatol. 2016 Sep; 2016 May 17. PMID: 27212241

Cadamuro M, Spagnuolo G, Sambado L, Indraccolo S, Nardo G, Rosato A, Brivio S, Caslini C, Stecca T, Massani M, Bassi N, Novelli E, Spirli C, Fabris L, Strazzabosco M: Low-Dose Paclitaxel Reduces S100A4 Nuclear Import to Inhibit Invasion and Hematogenous Metastasis of Cholangiocarcinoma. Cancer Res. 2016 Aug 15; 2016 Jun 21. PMID: 27328733

Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M: Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology. 2016 Mar; 2016 Jan 16. PMID: 26645994

Fabris L, Brivio S, Cadamuro M, Strazzabosco M: Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype. Stem Cells Int. 2016; 2016 Jan 6. PMID: 26880950

Brivio S, Cadamuro M, Fabris L, Strazzabosco M: Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma? J Clin Med. 2015 Dec 19; 2015 Dec 19. PMID: 26703747

Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M: Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage. Hepatology. 2015 Dec; 2015 Oct 10. PMID: 26313562

Scirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M: Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium. Hepatology. 2015 Nov; 2015 Aug 28. PMID: 26199136

Cortesi PA, Ciaccio A, Belleli G, Rota M, Rota M, Conti S, Mantovani LG, Annoni G, Strazzabosco M: Should Sofosbuvir-Based All-Oral Treatment Be Considered In Elderly Chronic Hepatitis C Patients? Value Health. 2015 Nov; 2015 Oct 20. PMID: 26533518

Morton SD, Cadamuro M, Brivio S, Vismara M, Stecca T, Massani M, Bassi N, Furlanetto A, Joplin RE, Floreani A, Fabris L, Strazzabosco M: Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation. Oncotarget. 2015 Sep 22. PMID: 26296968

Belli LS, Romagnoli R, Nardi A, Marianelli T, Donato F, Corradini SG, Iemmolo RM, Morelli C, Pasulo L, Rendina M, De Martin E, Ponziani FR, Volpes R, Strazzabosco M, Angelico M, Liver Match Investigators.: Recipient female gender is a risk factor for graft loss after liver transplantation for chronic hepatitis C: Evidence from the prospective Liver Match cohort. Dig Liver Dis. 2015 Aug; 2015 Apr 16. PMID: 26055490

Cortesi PA, Mantovani LG, Ciaccio A, Rota M, Mazzarelli C, Cesana G, Strazzabosco M, Belli LS: Cost-Effectiveness of New Direct-Acting Antivirals to Prevent Post-Liver Transplant Recurrent Hepatitis. Am J Transplant. 2015 Jul. PMID: 26086300

Strazzabosco M, Fabris L, Albano E: Osteopontin: a new player in regulating hepatic ductular reaction and hepatic progenitor cell responses during chronic liver injury. Gut. 2014 Nov; 2014 Jul 23. PMID: 25056656

Strazzabosco M, Fabris L: Neural cell adhesion molecule and polysialic acid in ductular reaction: the puzzle is far from completed, but the picture is becoming more clear. Hepatology. 2014 Nov; 2014 Oct 1. PMID: 24995463

Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, Keitel V, Schramm C, Marschall HU, Karlsen TH, Melum E, Kaser A, Eksteen B, Strazzabosco M, Manns M, Trauner M, International PSC Study Group (IPSCSG).: Characterization of animal models for primary sclerosing cholangitis (PSC). J Hepatol. 2014 Jun; 2014 Feb 19. PMID: 24560657

Angelico M, Nardi A, Romagnoli R, Marianelli T, Corradini SG, Tandoi F, Gavrila C, Salizzoni M, Pinna AD, Cillo U, Gridelli B, De Carlis LG, Colledan M, Gerunda GE, Costa AN, Strazzabosco M, Liver Match Study Investigators.: A Bayesian methodology to improve prediction of early graft loss after liver transplantation derived from the liver match study. Dig Liver Dis. 2014 Apr; 2014 Jan 9. PMID: 24411484

Morell CM, Strazzabosco M: Notch signaling and new therapeutic options in liver disease. J Hepatol. 2014 Apr; 2013 Dec 3. PMID: 24308992

Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M: Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology. 2013 Nov; 2013 Sep 30. PMID: 23744610

Kim AK, Dziura J, Strazzabosco M: Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma: the egg of columbus or another illusion? Hepatology. 2013 Aug. PMID: 23703812

Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M: Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. J Hepatol. 2013 Jul; 2013 Mar 7. PMID: 23500150

Spirli C, Strazzabosco M: Vascular endothelial growth factors in progenitor cells mediated liver repair. Hepatobiliary Surg Nutr. 2013 Apr. PMID: 24570918

Strazzabosco M, Fabris L: The balance between Notch/Wnt signaling regulates progenitor cells' commitment during liver repair: mystery solved? J Hepatol. 2013 Jan; 2012 Aug 15. PMID: 22902547

Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M: Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib. Hepatology. 2012 Dec; 2012 Aug 27. PMID: 22653837

Strazzabosco M, Fabris L: Development of the bile ducts: essentials for the clinical hepatologist. J Hepatol. 2012 May; 2012 Jan 13. PMID: 22245898

Spirli C, Locatelli L, Fiorotto R, Morell CM, Fabris L, Pozzan T, Strazzabosco M: Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes. Hepatology. 2012 Mar. PMID: 21987453

Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M: Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice. Gastroenterology. 2011 Oct; 2011 Jun 26. PMID: 21712022

Strazzabosco M, Somlo S: Polycystic liver diseases: congenital disorders of cholangiocyte signaling. Gastroenterology. 2011 Jun; 2011 Apr 22. PMID: 21515270

Wrzesinski SH, Taddei TH, Strazzabosco M: Systemic therapy in hepatocellular carcinoma. Clin Liver Dis. 2011 May. PMID: 21689622

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M: Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. Hepatology. 2010 May. PMID: 20131403

Strazzabosco M: Foxa1 and Foxa2 regulate bile duct development in mice. J Hepatol. 2010 May; 2010 Feb 18. PMID: 20347503

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M: ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology. 2010 Jan; 2009 Sep 18. PMID: 19766642

Strazzabosco M, Fiorotto R, Melero S, Glaser S, Francis H, Spirli C, Alpini G: Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation. Hepatology. 2009 Jul. PMID: 19444869

Nishihori T, Strazzabosco M, Saif MW: Incidence and management of colorectal cancer in liver transplant recipients. Clin Colorectal Cancer. 2008 Jul. PMID: 18650194

Rogart JN, Iyer A, Robert ME, Levy G, Strazzabosco M: Type I autoimmune hepatitis presenting with acute liver failure in the setting of wild mushroom ingestion. J Clin Gastroenterol. 2008 Jul. PMID: 18496396

Strazzabosco M, Fabris L: Functional anatomy of normal bile ducts. Anat Rec (Hoboken). 2008 Jun. PMID: 18484611

Fiorotto R, Spirlì C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M: Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion. Gastroenterology. 2007 Nov; 2007 Sep 2. PMID: 17983806

Benedetti A, Strazzabosco M, Ng OC, Boyer JL: Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes. Proc Natl Acad Sci U S A. 1994 Jan 18. PMID: 8290601

Bruck R, Benedetti A, Strazzabosco M, Boyer JL: Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL. Am J Physiol. 1993 Aug. PMID: 8368316

Benedetti A, Strazzabosco M, Corasanti JG, Haddad P, Graf J, Boyer JL: Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH. Am J Physiol. 1991 Sep. PMID: 1887897

Strazzabosco M, Mennone A, Boyer JL: Intracellular pH regulation in isolated rat bile duct epithelial cells. J Clin Invest. 1991 May. PMID: 2022723

Strazzabosco M, Sakisaka S, Hayakawa T, Boyer JL: Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers. Am J Physiol. 1991 Jan. PMID: 1987808

Tamar Hamosh Taddei, MD

Reiss KA, Yu S, Mamtani R, Mehta R, D'Addeo K, Wileyto EP, Taddei TH, Kaplan DE: Starting Dose of Sorafenib for the Treatment of Hepatocellular Carcinoma: A Retrospective, Multi-Institutional Study. J Clin Oncol. 2017 Sep 5; 2017 Sep 5. PMID: 28872925

Njei B, Taddei TH: Pursuing a Gastroenterology Fellowship as a Foreign Medical Graduate. Dig Dis Sci. 2017 Aug. PMID: 28555326

Vilarinho S, Erson-Omay EZ, Mitchell-Richards K, Cha C, Nelson-Williams C, Harmancı AS, Yasuno K, Günel M, Taddei TH: Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination. J Hepatol. 2017 Jul; 2017 Mar 18. PMID: 28323122

Taddei TH, Lo Re V 3rd, Justice AC: HIV, Aging, and Viral Coinfections: Taking the Long View. Curr HIV/AIDS Rep. 2016 Oct. PMID: 27614654

Langberg KM, Taddei TH: Balancing quality with quantity: The role of palliative care in managing decompensated cirrhosis. Hepatology. 2016 Oct; 2016 Aug 5. PMID: 27388118

Ooka K, Onyiuke I, Zhang X, Taddei TH: Protective altruistic phlebotomy: hereditary haemochromatosis presenting as hepatocellular carcinoma in a non-cirrhotic 83-year-old man. BMJ Case Rep. 2016 Sep 2; 2016 Sep 2. PMID: 27591041

Taddei TH: Learning from the Melbourne experience: How reliable are cancer registry data for hepatocellular carcinoma? Hepatology. 2016 Apr; 2016 Mar 1. PMID: 26764271

Vilarinho S, Taddei TH: New frontier in liver cancer treatment: oncolytic viral therapy. Hepatology. 2014 Jan; 2013 Nov 15. PMID: 23836532

Bari K, Aslanian HR, Pollak J, Reiner E, Salem RR, Taddei TH, Emre SH, Jamidar PA: Emphysematous Cholecystitis Resulting in Secondary Biliary Cirrhosis: A Rare Complication of Endoscopic Retrograde Cholangiopancreatography. ACG Case Rep J. 2013 Oct; 2013 Oct 8. PMID: 26157820

Taddei TH: A multidisciplinary approach: group dynamics. J Clin Gastroenterol. 2013 Jul. PMID: 23632364

Sahakian AB, Krishnamoorthy S, Taddei TH: Necrotizing pancreatitis complicated by fistula and upper gastrointestinal hemorrhage. Clin Gastroenterol Hepatol. 2011 Jul; 2011 Feb 4. PMID: 21296188

Kulkarni S, Taddei TH: When should a hepatitis C-positive ESRD patient receive a renal transplant? Semin Dial. 2011 Jul-Aug; 2011 Jul 29. PMID: 21801216

Wrzesinski SH, Taddei TH, Strazzabosco M: Systemic therapy in hepatocellular carcinoma. Clin Liver Dis. 2011 May. PMID: 21689622

Taddei TH, Dziura J, Chen S, Yang R, Hyogo H, Sullards C, Cohen DE, Pastores G, Mistry PK: High incidence of cholesterol gallstone disease in type 1 Gaucher disease: characterizing the biliary phenotype of type 1 Gaucher disease. J Inherit Metab Dis. 2010 Jun; 2010 Mar 31. PMID: 20354791

Taddei TH, Kacena KA, Yang M, Yang R, Malhotra A, Boxer M, Aleck KA, Rennert G, Pastores GM, Mistry PK: The underrecognized progressive nature of N370S Gaucher disease and assessment of cancer risk in 403 patients. Am J Hematol. 2009 Apr. PMID: 19260119

Jittima Weerachayaphorn, PhD

Kruglov E, Ananthanarayanan M, Sousa P, Weerachayaphorn J, Guerra MT, Nathanson MH: Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP. Biochem Biophys Res Commun. 2017 May 6; 2017 Mar 19. PMID: 28327356

Khamphaya T, Chansela P, Piyachaturawat P, Suksamrarn A, Nathanson MH, Weerachayaphorn J: Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats. Eur J Pharmacol. 2016 Oct 15; 2016 Jul 27. PMID: 27475677

Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH: Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes. Gastroenterology. 2015 Jul; 2015 Mar 18. PMID: 25796361

Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL: Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. J Hepatol. 2014 Jan; 2013 Aug 23. PMID: 23978715

Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL: Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am J Physiol Gastrointest Liver Physiol. 2012 May 1; 2012 Feb 16. PMID: 22345550

Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 2010 Apr 15. PMID: 20395535

Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL: Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression. Hepatology. 2009 Nov. PMID: 19821532

Xinshou Ouyang, PhD

Fujimoto M, Tsutsui H, Xinshou O, Tokumoto M, Watanabe D, Shima Y, Yoshimoto T, Hirakata H, Kawase I, Nakanishi K, Kishimoto T, Naka T: Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases. Int Immunol. 2004 Feb. PMID: 14734616