Research is one of the cornerstones of our Section. Our Section currently has over $8 million per year in research funding from NIDDK, more than any other Digestive Diseases Section in the country. Our faculty are engaged in a wide range of both basic laboratory research activities and patient-oriented clinical research. Details of an investigators work can be found through links on our faculty menu.
Major areas of laboratory research include:
- regulation of bile secretion by the liver, including liver cell biology (Drs. James L. Boyer and Michael H. Nathanson),
- basis for portal hypertension, variceal bleeding and other complications of cirrhosis (Drs. Roberto Groszmann, Guadalupe Garcia-Tsao, and Yasuko Iwakiri),
- mechanisms responsible for pancreatic inflammation and pancreatitis (Dr. Fred S. Gorelick), genetics and immunobiology of inflammatory bowel disease (Drs. Judy Cho and Clara Abraham),
- liver growth, cancer, and stem cells (Drs. Mario Strazzabosco, Chuhan Chung, and Scott Swenson),
- bile ductular secretion, focusing on basic mechanisms (Drs. Michael Nathanson and Mario Strazzabosco),
- immunology of the healthy and diseased liver (Dr. Wajahat Mehal),
- metabolic liver diseases (Dr. Tamar Taddei), and
- colon physiology and mechanisms of diarrhea (Dr. Henry J. Binder).
Major areas of clinical research include:
- complications and treatment of cirrhosis (Drs. Roberto Groszmann, Guadalupe Garcia-Tsao), viral hepatitis (Dr. Joe Lim), liver cancer (Dr. Mario Strazzabosco), and IBD (Drs. Judy Cho and Deborah Proctor),
- motility disorders of the esophagus, optimal application of advanced endoscopic techniques to clinical problems including gastrointestinal bleeding, graft-versus-host disease and pancreatic biliary disorders (Dr. Harry Aslanian),
- advanced endoscopic techniques; pancreatitis; sphincter of oddi dysfunction as well as other clinical aspects of biliary and pancreatic disease (Dr. Priya Jamidar),
- endoscopic outcomes research (Dr. Anil Nagar),
- diverticulitis (Dr. Martin Floch), and
- newer endoscopic modalities (Dr. Caroline Loeser).
Related programs include:
- the Yale Liver Center, an NIH-funded facility that supports both basic and clinical research in liver diseases,
- the Yale IBD Program, which is home to the NIH/NIDDK IBD Genetics Consortium, and
- the Yale Center for Clinical Investigation, an NIH-funded facility that supports investigations and novel treatment protocols in patients.