Research


Research is one of the cornerstones of our Section. Our Section currently has over $8 million per year in research funding from NIDDK, more than any other Digestive Diseases Section in the country. Our faculty are engaged in a wide range of both basic laboratory research activities and patient-oriented clinical research. Details of an investigators work can be found through links on our faculty menu.

Major areas of laboratory research include:

Major areas of clinical research include:

  • complications and treatment of cirrhosis (Drs. Roberto Groszmann, Guadalupe Garcia-Tsao), viral hepatitis (Dr. Joe Lim), liver cancer (Dr. Mario Strazzabosco), and IBD (Drs. Judy Cho and Deborah Proctor),
  • motility disorders of the esophagus, optimal application of advanced endoscopic techniques to clinical problems including gastrointestinal bleeding, graft-versus-host disease and pancreatic biliary disorders (Dr. Harry Aslanian),
  • advanced endoscopic techniques; pancreatitis; sphincter of oddi dysfunction as well as other clinical aspects of biliary and pancreatic disease (Dr. Priya Jamidar),
  • endoscopic outcomes research (Dr. Anil Nagar),
  • diverticulitis (Dr. Martin Floch), and
  • newer endoscopic modalities (Dr. Caroline Loeser).

Related programs include: 

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Clara Abraham, MD

Professor

Research Interests

Colitis, Ulcerative; Crohn Disease; Immune System; Immunity, Innate; Inflammatory Bowel Diseases; T-Lymphocytes

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Harry Aslanian, MD

Professor of Medicine (Digestive Diseases)

Associate Director, Endoscopy

Director, Yale Advanced Endoscopy Fellowship

Research Interests

Biliary Tract Diseases; Colonic Polyps; Digestive System Diseases; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Endoscopy; Gastrointestinal Hemorrhage; Pancreatic Cyst; Pancreatic Diseases; Pancreatic Neoplasms

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Henry J. Binder, MD

Professor Emeritus of and Senior Research Scientist in Medicine (Digestive Diseases)

Research Interests

Adenosine Triphosphatases; Digestive System Diseases; Epithelial Cells; Fatty Acids, Volatile; Ion Transport

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James Lorenzen Boyer, MD, FACEP

Ensign Professor of Medicine (Digestive Diseases)

Emeritus Director, Yale Liver Center

Research Interests

Bile; Cholangitis, Sclerosing; Cholestasis; Digestive System Diseases; Hepatitis; Jaundice; Liver

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Judy Cho, MD

Director, Inflammatory Bowel Disease Center

Research Interests

Digestive System Diseases; Inflammatory Bowel Diseases

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Guadalupe Garcia-Tsao, MD

Professor of Medicine (Digestive Diseases)

Chief, Digestive Diseases, VA-CT Healthcare System

Director, Clinical and Translational Core, Yale Liver Center

Program Director, VA-CT Hepatitis C Resource Center

Research Interests

Ascites; Digestive System Diseases; Gastroesophageal Reflux; Hepatitis C; Hepatorenal Syndrome; Liver Cirrhosis; Peritonitis; Veterans

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Fred Gorelick, MD

Henry J. and Joan W. Binder Professor of Medicine (Digestive Diseases) and of Cell Biology

Deputy Director, Yale M.D., Ph.D. Program

Research Interests

AMP-Activated Protein Kinases; Autophagy; Cell Biology; Digestive System Diseases; Gastrointestinal Diseases; Pancreas, Exocrine; Pancreatic Diseases; Pancreatitis; Proteolysis

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Roberto J Groszmann, MD

Professor Emeritus of Medicine (Digestive Diseases)

Research Interests

Ascites; Digestive System Diseases; Hypertension; Liver Cirrhosis

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Yasuko Iwakiri, PhD

Associate Professor of Medicine (Digestive Diseases)

Research Interests

Antigens, CD147; Endothelial Cells; Hypertension, Portal; Liver Cirrhosis; Liver Cirrhosis, Biliary; Liver Regeneration; Neoplasms by Histologic Type; Nitric Oxide; Vascular Diseases

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Priya Arvind Jamidar, FACG, FASGE, MBChB

Professor of Medicine (Digestive Diseases)

Director, Endoscopy

Research Interests

Biliary Tract Diseases; Pancreas; Sphincter of Oddi

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Joseph K Lim, MD

Associate Professor of Medicine (Digestive Diseases)

Director, Yale Viral Hepatitis Program

Research Interests

Carcinoma, Hepatocellular; Clinical Trial; Delivery of Health Care; Fatty Liver; Health Services Research; Hepatitis B; Hepatitis C; Hepatitis D; Liver Cirrhosis; Liver Neoplasms; Quality of Health Care

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Wajahat Zafar Mehal, PhD, MD

Professor of Medicine (Digestive Diseases)

Director of Yale Weight Loss Program

Research Interests

Digestive System Diseases; Fibrosis; Hepatitis; Inflammation; Liver; Weight Loss; Weight Reduction Programs

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Anil Bernard Nagar, MD

Associate Professor of Medicine (Digestive Diseases)

Endoscopy Director, West Haven VAMC

Research Interests

Barrett Esophagus; Colorectal Neoplasms; Digestive System Diseases; Endoscopy; Gastrointestinal Diseases; Microscopy, Confocal; Pancreatitis

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Michael Harris Nathanson, MD, PhD

Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology

Section Chief, Digestive Diseases

Director, Yale Liver Center

Director, Center for Cell and Molecular Imaging

Research Interests

Calcium Signaling; Cell Biology; Cell Nucleus; Digestive System Diseases; Hepatocytes; Liver

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Deborah Denise Proctor, MD

Professor of Medicine (Digestive Diseases)

Medical Director, Inflammatory Bowel Disease Program

Site Director, Universidad del Valle, Cali, Columbia and Yale/Stanford, Johnson and Johnson Global Health Scholar Program

Board of Directors and Treasurer, Honduras Children's Project

Research Interests

Colitis, Ulcerative; Crohn Disease; Gastrointestinal Hemorrhage; Global Health; Ileitis; Inflammatory Bowel Diseases; Rectal Fistula; Telangiectasia, Hereditary Hemorrhagic

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Mario Strazzabosco, MD, PhD

Professor of Medicine

Clinical Program Leader, Liver Cancer Program

Deputy Director, Yale Liver Center

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Scott Swenson, MD, PhD

Research Interests

Hepatitis; Liver Cirrhosis; Pancreatic Diseases

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Tamar Hamosh Taddei, MD

Associate Professor of Medicine (Digestive Diseases)

Research Interests

Carcinoma, Hepatocellular; Delivery of Health Care; Digestive System Diseases; Translational Medical Research

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